This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Koratkar, R. Articles by Siracusa, L. D. Search for Related Content PubMed PubMed Citation Articles by Koratkar, R. Articles by Siracusa, L. D.

The CAST/Ei Strain Confers Significant Protection against Apc^Min Intestinal Polyps, Independent of the Resistant Modifier of Min 1 (Mom1^R) Locus¹

Department of Microbiology and Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107 [R. K., L. D. S.], and Biostatistics Section, Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107 [E. P., W. W. H.]

Intestinal adenoma development in Apc^Min mice is influenced by genetic background. We generated a congenic line between the CAST and B6 inbred strains to study the effects of a resistant CAST background in the absence of a major modifier locus, Modifier of Min 1 (Mom1^R). Progeny from a CAST.B6 Mom1^R/S x B6 Apc^Min/+ intercross were 110 or 200 days of age and screened for intestinal polyps. There was a significant decrease (P < 0.0001) in polyp multiplicity and size in CASTB6F1 Mom1^R/S, Apc^Min/+ and CASTB6F1 Mom1^S/S, Apc^Min/+ progeny compared with B6 Mom1^S/S, Apc^Min/+ controls. A complete absence of colon polyps was observed in all mice heterozygous for the CAST background. These results demonstrate that the CAST strain carries dominant modifier loci, in addition to Mom1^R, that dramatically reduce polyp burden in the small intestine and eliminate polyp burden in the colon of Apc^Min mice.

This article has been cited by other articles:

				A. A. Baran, K. A. Silverman, J. Zeskand, R. Koratkar, A. Palmer, K. McCullen, W. J. Curran Jr, T. B. Edmonston, L. D. Siracusa, and A. M. Buchberg The modifier of Min 2 (Mom2) locus: Embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression Genome Res., May 1, 2007; 17(5): 566 - 576. [Abstract] [Full Text] [PDF]