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High Frequency of Micronuclei in Peripheral Blood Lymphocytes as Index of Susceptibility to Pleural Malignant Mesothelioma

National Cancer Research Institute, Toxicological Evaluation [C. B., E. P., E. L.] and Environmental Epidemiology [R. F., M. N., R. P.], 16132 Genoa; Pneumology, Ospedale S. Bartolomeo, 19038 Sarzana [P. A. C.]; Pneumology, AO Villa Scassi, 16149 Genoa [C. S.]; Department of Health Sciences, University of Genoa, 16132 Genoa [P. G. C.]; and Ospedale S. Pietro e Paolo, ASL11, 13011 Borgosesia and S. Maurgeri Foundation Institute for Research and Care, 27100 Pavia [L. M.], Italy

We evaluated the frequency of micronuclei (MN) in peripheral blood lymphocytes of patients with pleural malignant mesotelioma (MM), lung cancer, benign respiratory diseases, and healthy controls. A significant increased frequency of MN was observed in patients with MM in comparison with all the other groups (median, 11.4 binucleated MN/1000 binucleated cells versus 5.1, 6.1, and 6.2, respectively). No association was found between MN and asbestos exposure. Recently, genetic susceptibility associated with asbestos exposure has been recognized in the development of MM. The presence of high frequency of MN in peripheral blood lymphocytes of patients with MM could represent a useful index of individual susceptibility to this tumor.

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