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[Cancer Research 62, 5657-5663, October 15, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

The Use of Interleukin 12-secreting Neural Stem Cells for the Treatment of Intracranial Glioma1

Moneeb Ehtesham, Peter Kabos, Andrea Kabosova, Toomas Neuman, Keith L. Black and John S. Yu2

Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048

Neural stem cells (NSCs) are capable of tracking migrating glioma cells. To exploit this tropism to generate an antitumor T-cell response, particularly against disseminating tumor pockets, we inoculated intracranial glioma-bearing mice with interleukin 12 (IL-12) producing NSCs. Intratumoral therapy with IL-12-secreting NSCs prolonged survival compared to treatment with nonsecretory NSCs or saline. NSCs demonstrated strong tropism for disseminating glioma, and IL-12-secreting NSC therapy was associated with enhanced T-cell infiltration in tumor microsatellites and long-term antitumor immunity. These results indicate that the use of tumor tracking NSCs represents a potent new therapeutic modality for glioma.




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