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Identical T-cell Receptor Transcripts in Multiple Melanoma Metastases¹

Department of Dermatology, Julius Maximilians-University, D-97080 Würzburg, Germany [D. S., E. F., E-B. B., J. C. B.], and Tumor Cell Biology, Division of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark [P. t. S.]

Immune therapy for melanoma largely relies on preexisting T-cell responses. However, recent reports demonstrated the localized nature of such responses. Thus, we characterized the effect of immune therapy on the distribution of clonotypic T cells. To this end, we analyzed the T-cell receptor repertoire of multiple metastases of differentially treated melanoma patients revealing oligoclonal T-cell responses and the occurrence of identical T-cell clones in several metastases. However, these findings were not limited to immune therapy but were also observed after chemotherapy, suggesting its similar impact on the distribution of T cells.

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				M. Willhauck, C. Scheibenbogen, M. Pawlita, T. Mohler, E. Thiel, and U. Keilholz Restricted T-Cell Receptor Repertoire in Melanoma Metastases Regressing after Cytokine Therapy Cancer Res., July 1, 2003; 63(13): 3483 - 3485. [Abstract] [Full Text] [PDF]