| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Advances in Brief |
Sunnybrook and Women’s College Health Sciences Centre, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M4N 3M5 Canada
The effect of antivascular therapy on blood flow in superficial tumors was monitored using novel high frequency Doppler (HFD) ultrasound techniques. Human melanoma cells (MeWo) were injected orthotopically into the skin of athymic nude mice. Volumetric HFD imaging of established melanomas detected a significant reduction in blood flow 4 h after injection of the tumor vascular targeting agent ZD6126 followed by a recovery of flow by 24 h after injection. Measurements of tumor perfusion in situ by Hoechst 33342 staining correlated with the ultrasound results. This study demonstrates the feasibility of HFD as a noninvasive, quantitative tool for following longitudinally the effects of antivascular therapy on blood flow in superficial tumors.
This article has been cited by other articles:
|
|
 |
|
  D. Zhao, E. Richer, P. P. Antich, and R. P. Mason Antivascular effects of combretastatin A4 phosphate in breast cancer xenograft assessed using dynamic bioluminescence imaging and confirmed by MRI FASEB J, July 1, 2008; 22(7): 2445 - 2451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Xuan, M. Bygrave, H. Jiang, F. Valiyeva, J. Dunmore-Buyze, D. W. Holdsworth, J. I. Izawa, G. Bauman, M. Moussa, S. F. Winter, et al. Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound Cancer Res., March 15, 2007; 67(6): 2830 - 2839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Holloway, A. W. Beck, L. Shivakumar, J. Shih, J. B. Fleming, and R. A. Brekken Selective Blockade of Vascular Endothelial Growth Factor Receptor 2 With an Antibody Against Tumor-Derived Vascular Endothelial Growth Factor Controls the Growth of Human Pancreatic Adenocarcinoma Xenografts Ann. Surg. Oncol., August 1, 2006; 13(8): 1145 - 1155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. V. Beerepoot, S. A. Radema, E. O. Witteveen, T. Thomas, C. Wheeler, S. Kempin, and E. E. Voest Phase I Clinical Evaluation of Weekly Administration of the Novel Vascular-Targeting Agent, ZD6126, in Patients With Solid Tumors J. Clin. Oncol., April 1, 2006; 24(10): 1491 - 1498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Franco, S. Man, L. Chen, U. Emmenegger, Y. Shaked, A. M. Cheung, A. S. Brown, D. J. Hicklin, F. S. Foster, and R. S. Kerbel Targeted Anti-Vascular Endothelial Growth Factor Receptor-2 Therapy Leads to Short-term and Long-term Impairment of Vascular Function and Increase in Tumor Hypoxia. Cancer Res., April 1, 2006; 66(7): 3639 - 3648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Wirtzfeld, G. Wu, M. Bygrave, Y. Yamasaki, H. Sakai, M. Moussa, J. I. Izawa, D. B. Downey, N. M. Greenberg, A. Fenster, et al. A New Three-Dimensional Ultrasound Microimaging Technology for Preclinical Studies Using a Transgenic Prostate Cancer Mouse Model Cancer Res., July 15, 2005; 65(14): 6337 - 6345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Graham, L. A. Wirtzfeld, L. T. MacKenzie, C. O. Postenka, A. C. Groom, I. C. MacDonald, A. Fenster, J. C. Lacefield, and A. F. Chambers Three-dimensional High-Frequency Ultrasound Imaging for Longitudinal Evaluation of Liver Metastases in Preclinical Models Cancer Res., June 15, 2005; 65(12): 5231 - 5237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hsu, C.-N. Chen, L.-T. Chen, C.-Y. Wu, F.-J. Hsieh, and A.-L. Cheng Effect of Thalidomide in Hepatocellular Carcinoma: Assessment with Power Doppler US and Analysis of Circulating Angiogenic Factors Radiology, May 1, 2005; 235(2): 509 - 516. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Testa, D. Mansueto, D. Lorusso, E. Fruscella, D. Basso, G. Scambia, and G. Ferrandina Angiographic Power 3-Dimensional Quantitative Analysis in Gynecologic Solid Tumors: Feasibility and Reproducibility J. Ultrasound Med., June 1, 2004; 23(6): 821 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Manotham, T. Tanaka, M. Matsumoto, T. Ohse, T. Miyata, R. Inagi, K. Kurokawa, T. Fujita, and M. Nangaku Evidence of Tubular Hypoxia in the Early Phase in the Remnant Kidney Model J. Am. Soc. Nephrol., May 1, 2004; 15(5): 1277 - 1288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. E. Thorpe Vascular Targeting Agents as Cancer Therapeutics Clin. Cancer Res., January 15, 2004; 10(2): 415 - 427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Krix, F. Kiessling, S. Vosseler, N. Farhan, M. M. Mueller, P. Bohlen, N. E. Fusenig, and S. Delorme Sensitive Noninvasive Monitoring of Tumor Perfusion during Antiangiogenic Therapy by Intermittent Bolus-Contrast Power Doppler Sonography Cancer Res., December 1, 2003; 63(23): 8264 - 8270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H-D Liang and M J K Blomley The role of ultrasound in molecular imaging Br. J. Radiol., December 1, 2003; 76(suppl_2): S140 - S150. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Cell Growth & Differentiation |
