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[Cancer Research 62, 6390-6394, November 15, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

Gene Silencing of the Tyrosine Phosphatase SHP1 Gene by Aberrant Methylation in Leukemias/Lymphomas1

Takashi Oka2, Mamoru Ouchida, Maho Koyama, Yoichiro Ogama, Shinichi Takada, Yoko Nakatani, Takehiro Tanaka, Tadashi Yoshino, Kazuhiko Hayashi, Nobuya Ohara, Eisaku Kondo, Kiyoshi Takahashi, Junjiro Tsuchiyama, Mitsune Tanimoto, Kenji Shimizu and Tadaatsu Akagi

Department of Pathology [T. O., S. T., Y. N., T. T., T. Y., K. H., N. O., E. K., K. T., T. A.], Department of Molecular Genetics [M. O., K. S.], Department of Pediatrics [M. K.], and Second Department of Internal Medicine [Y. O., M. T.], Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, and First Department of Medicine, Niigata University, School of Medicine, Niigata 951 [J. T.], Japan

High-frequent silencing of hematopoietic cell-specific protein-tyrosine phosphatase SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas, as well as in many hematopoietic cell lines, which is supported by our previous observation of strong decrease of SHP1 mRNA and protein. The promoter methylation of the SHP1 gene was clearly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers near the SHP1 gene was shown in 79% of informative acute lymphoblastic leukemia cases. These results suggest that functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas.




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Copyright © 2002 by the American Association for Cancer Research.