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Evidence for a Hereditary Neuroblastoma Predisposition Locus at Chromosome 16p12–13¹

Department of Pediatrics, University of Pennsylvania School of Medicine and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318 [J. M. M., M. J. W., Y. M., G. H., C. G., P. S. W., M. D. H., T. M., G. M. B., S. S.]; Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 [T. R. R.]; and Department of Medicine, Northwestern University School of Medicine, Chicago, Illinois 60208 [M. U.]

Hereditary predisposition to develop neuroblastoma (Online Mendelian Inheritance in Man 256700), a pediatric cancer of the sympathetic nervous system, segregates as an autosomal dominant Mendelian trait. We performed linkage analysis on seven families with two or more first-degree relatives affected with neuroblastoma to localize a hereditary neuroblastoma predisposition gene. A single interval at chromosome bands 16p12–13 was the only genomic region consistent with linkage (LOD_MAX = 3.30 at D16S764). Identification of informative recombination events in linked families defined a 28.0-cM region between D16S748 and D16S769 that cosegregated with the disease in each pedigree. Loss of heterozygosity was identified in 5 of 11 familial neuroblastomas and 68 of 336 nonfamilial neuroblastomas (20.2%) at multiple 16p polymorphic loci. A 14.5-cM smallest region of overlap of somatic deletions was identified within the interval defined by linkage analysis (tel-D16S500-D16S412-cen). Taken together, these data suggest that a hereditary neuroblastoma predisposition gene (HNB1) is located at 16p12–13 and that disruption of this gene may contribute to the pathogenesis of nonfamilial neuroblastomas.

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