Cancer Research Cancer Epigenetics Protein Translation and Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mora, L. B.
Right arrow Articles by Jove, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mora, L. B.
Right arrow Articles by Jove, R.
[Cancer Research 62, 6659-6666, November 15, 2002]
© 2002 American Association for Cancer Research

Tumor Biology

Constitutive Activation of Stat3 in Human Prostate Tumors and Cell Lines

Direct Inhibition of Stat3 Signaling Induces Apoptosis of Prostate Cancer Cells1

Linda B. Mora2, Ralf Buettner2, John Seigne, Jose Diaz, Nazeel Ahmad, Roy Garcia, Tammy Bowman, Robert Falcone, Rita Fairclough, Alan Cantor, Carlos Muro-Cacho, Sandy Livingston, James Karras, Julio Pow-Sang and Richard Jove3

Departments of Oncology [L. B. M., R. B., J. S., J. D., N. A., R. G., T. B., A. C., C. M-C., J. P-S., R. J.], Pathology [L. B. M., J. D., N. A., R. Fal., R. Fai., C. M-C., S. L., R. J.], and Surgery [J. S., J. P-S.], H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida 33612, and Antisense Drug Discovery, Isis Pharmaceuticals, Carlsbad, California 92008 [J. K.]

Signal transducers and activators of transcription (STATs) were identified originally as key components of cytokine signaling pathways. More recently, constitutive activation of STAT proteins has been detected in a wide variety of human tumor specimens and tumor cell lines. Here, we examined the activation of one STAT family member, Stat3, in human prostate cancer cell lines and primary prostate tumors. An analysis of 45 adenocarcinomas obtained at radical prostatectomy revealed elevated levels of constitutive Stat3 activation in 37 (82%) of 45 of the tumors compared with matched adjacent nontumor prostate tissues. A highly specific immunohistochemical assay for detection of phospho-Stat3 revealed that elevated Stat3 activity was localized primarily in the tumor cells of prostate carcinoma specimens. Furthermore, higher levels of Stat3 activation in patient specimens were correlated significantly with more malignant tumors exhibiting higher Gleason scores. In addition, all of the three human prostate cancer cell lines examined (DU145, PC3, and LNCaP) displayed constitutive activation of Stat3. Substantially lower levels of Stat3 activation were detected in LNCaP cells; however, stimulation with interleukin 6 induced a significant increase in Stat3 DNA-binding activity in these cells. Moreover, the direct inhibition of constitutive Stat3 signaling in DU145 cells using antisense Stat3 oligonucleotides induced growth inhibition and apoptosis. Our findings demonstrate that constitutive activation of Stat3 occurs frequently in primary prostate adenocarcinomas and is critical for the growth and survival of prostate cancer cells. These studies further suggest that Stat3 signaling represents a potentially novel molecular target for prostate cancer therapy.




This article has been cited by other articles:


Home page
 Molecular Cancer TherapeuticsHome page
C. Yang, J. H. Schwab, A. J. Schoenfeld, F. J. Hornicek, K. B. Wood, G. P. Nielsen, E. Choy, H. Mankin, and Z. Duan
A novel target for treatment of chordoma: signal transducers and activators of transcription 3
Mol. Cancer Ther., September 1, 2009; 8(9): 2597 - 2605.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Wang, S. Haile, B. Comuzzi, A. H. Tien, J. Wang, T. M.K. Yong, A. E. Jelescu-Bodos, N. Blaszczyk, R. L. Vessella, B. A. Masri, et al.
Osteoblast-Derived Factors Induce an Expression Signature that Identifies Prostate Cancer Metastasis and Hormonal Progression
Cancer Res., April 15, 2009; 69(8): 3433 - 3442.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
R. P. Sahu and S. K. Srivastava
The Role of STAT-3 in the Induction of Apoptosis in Pancreatic Cancer Cells by Benzyl Isothiocyanate
J Natl Cancer Inst, February 4, 2009; 101(3): 176 - 193.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D.-S. Shin, H.-N. Kim, K. D. Shin, Y. J. Yoon, S.-J. Kim, D. C. Han, and B.-M. Kwon
Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells
Cancer Res., January 1, 2009; 69(1): 193 - 202.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
A. Zoubeidi, J. Rocha, F. Z. Zouanat, L. Hamel, E. Scarlata, A. G. Aprikian, and S. Chevalier
The Fer Tyrosine Kinase Cooperates with Interleukin-6 to Activate Signal Transducer and Activator of Transcription 3 and Promote Human Prostate Cancer Cell Growth
Mol. Cancer Res., January 1, 2009; 7(1): 142 - 155.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
H. Hu, H.-J. Lee, C. Jiang, J. Zhang, L. Wang, Y. Zhao, Q. Xiang, E.-O. Lee, S.-H. Kim, and J. Lu
Penta-1,2,3,4,6-O-galloyl-{beta}-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo
Mol. Cancer Ther., September 1, 2008; 7(9): 2681 - 2691.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. S. Ahn, G. Sethi, B. Sung, A. Goel, R. Ralhan, and B. B. Aggarwal
Guggulsterone, a Farnesoid X Receptor Antagonist, Inhibits Constitutive and Inducible STAT3 Activation through Induction of a Protein Tyrosine Phosphatase SHP-1
Cancer Res., June 1, 2008; 68(11): 4406 - 4415.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
K. Kataoka, D. J. Kim, S. Carbajal, J. L. Clifford, and J. DiGiovanni
Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis
Carcinogenesis, June 1, 2008; 29(6): 1108 - 1114.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. Abdulghani, L. Gu, A. Dagvadorj, J. Lutz, B. Leiby, G. Bonuccelli, M. P. Lisanti, T. Zellweger, K. Alanen, T. Mirtti, et al.
Stat3 Promotes Metastatic Progression of Prostate Cancer
Am. J. Pathol., June 1, 2008; 172(6): 1717 - 1728.
[Abstract] [Full Text] [PDF]

Home page
 aacredbookHome page
D. A Frank
Targeting Transcription Factors for Cancer Therapy
Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 335 - 341.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W.-K. Chu, P.-M. Dai, H.-L. Li, and J.-K. Chen
Transcriptional Activity of the {Delta}Np63 Promoter Is Regulated by STAT3
J. Biol. Chem., March 21, 2008; 283(12): 7328 - 7337.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Zhang, L. Gao, Y. Li, G. Lin, Y. Shao, K. Ji, H. Yu, J. Hu, D. V. Kalvakolanu, D. J. Kopecko, et al.
Effects of Plasmid-Based Stat3-Specific Short Hairpin RNA and GRIM-19 on PC-3M Tumor Cell Growth
Clin. Cancer Res., January 15, 2008; 14(2): 559 - 568.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. Zurney, K. E. Howard, and B. Sherry
Basal Expression Levels of IFNAR and Jak-STAT Components Are Determinants of Cell-Type-Specific Differences in Cardiac Antiviral Responses
J. Virol., December 15, 2007; 81(24): 13668 - 13680.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Z. Duan, J. Bradner, E. Greenberg, R. Mazitschek, R. Foster, J. Mahoney, and M. V. Seiden
8-Benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic Acid (SD-1008), a Novel Janus Kinase 2 Inhibitor, Increases Chemotherapy Sensitivity in Human Ovarian Cancer Cells
Mol. Pharmacol., November 1, 2007; 72(5): 1137 - 1145.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. S. Redell, A. Tsimelzon, S. G. Hilsenbeck, and D. J. Tweardy
Conditional overexpression of Stat3{alpha} in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern
J. Leukoc. Biol., October 1, 2007; 82(4): 975 - 985.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
R. Buettner, M. Huang, T. Gritsko, J. Karras, S. Enkemann, T. Mesa, S. Nam, H. Yu, and R. Jove
Activated Signal Transducers and Activators of Transcription 3 Signaling Induces CD46 Expression and Protects Human Cancer Cells from Complement-Dependent Cytotoxicity
Mol. Cancer Res., August 1, 2007; 5(8): 823 - 832.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Zhang, L. Gao, L. Zhao, B. Guo, K. Ji, Y. Tian, J. Wang, H. Yu, J. Hu, D. V. Kalvakolanu, et al.
Intratumoral Delivery and Suppression of Prostate Tumor Growth by Attenuated Salmonella enterica serovar typhimurium Carrying Plasmid-Based Small Interfering RNAs
Cancer Res., June 15, 2007; 67(12): 5859 - 5864.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Azare, K. Leslie, H. Al-Ahmadie, W. Gerald, P. H. Weinreb, S. M. Violette, and J. Bromberg
Constitutively Activated Stat3 Induces Tumorigenesis and Enhances Cell Motility of Prostate Epithelial Cells through Integrin {beta}6
Mol. Cell. Biol., June 15, 2007; 27(12): 4444 - 4453.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Siddiquee, S. Zhang, W. C. Guida, M. A. Blaskovich, B. Greedy, H. R. Lawrence, M. L. R. Yip, R. Jove, M. M. McLaughlin, N. J. Lawrence, et al.
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
PNAS, May 1, 2007; 104(18): 7391 - 7396.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. S. Punjabi, P. A. Carroll, L. Chen, and M. Lagunoff
Persistent Activation of STAT3 by Latent Kaposi's Sarcoma-Associated Herpesvirus Infection of Endothelial Cells
J. Virol., March 1, 2007; 81(5): 2449 - 2458.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
I. Bellezza, H. Neuwirt, C. Nemes, I. T. Cavarretta, M. Puhr, H. Steiner, A. Minelli, G. Bartsch, F. Offner, A. Hobisch, et al.
Suppressor of Cytokine Signaling-3 Antagonizes cAMP Effects on Proliferation and Apoptosis and Is Expressed in Human Prostate Cancer
Am. J. Pathol., December 1, 2006; 169(6): 2199 - 2208.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W.-C. Li, S.-L. Ye, R.-X. Sun, Y.-K. Liu, Z.-Y. Tang, Y. Kim, J. G. Karras, and H. Zhang
Inhibition of Growth and Metastasis of Human Hepatocellular Carcinoma by Antisense Oligonucleotide Targeting Signal Transducer and Activator of Transcription 3
Clin. Cancer Res., December 1, 2006; 12(23): 7140 - 7148.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Z. Duan, J. E. Bradner, E. Greenberg, R. Levine, R. Foster, J. Mahoney, and M. V. Seiden
SD-1029 Inhibits Signal Transducer and Activator of Transcription 3 Nuclear Translocation.
Clin. Cancer Res., November 15, 2006; 12(22): 6844 - 6852.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
K. W. Kim, R. W. Mutter, C. Cao, J. M. Albert, E. T. Shinohara, K. R. Sekhar, and B. Lu
Inhibition of signal transducer and activator of transcription 3 activity results in down-regulation of Survivin following irradiation.
Mol. Cancer Ther., November 1, 2006; 5(11): 2659 - 2665.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. S. Nagy, H. Rui, S. M. Stepkowski, J. Karras, and R. A. Kirken
A Preferential Role for STAT5, not Constitutively Active STAT3, in Promoting Survival of a Human Lymphoid Tumor
J. Immunol., October 15, 2006; 177(8): 5032 - 5040.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
R. P Singh and R. Agarwal
Mechanisms of action of novel agents for prostate cancer chemoprevention.
Endocr. Relat. Cancer, September 1, 2006; 13(3): 751 - 778.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. Kotha, M. Sekharam, L. Cilenti, K. Siddiquee, A. Khaled, A. S. Zervos, B. Carter, J. Turkson, and R. Jove
Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein.
Mol. Cancer Ther., March 1, 2006; 5(3): 621 - 629.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Shao, X. Xu, N. Jing, and D. J. Tweardy
Unique structural determinants for stat3 recruitment and activation by the granulocyte colony-stimulating factor receptor at phosphotyrosine ligands 704 and 744.
J. Immunol., March 1, 2006; 176(5): 2933 - 2941.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
N. Jing, Q. Zhu, P. Yuan, Y. Li, L. Mao, and D. J. Tweardy
Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer.
Mol. Cancer Ther., February 1, 2006; 5(2): 279 - 286.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Gritsko, A. Williams, J. Turkson, S. Kaneko, T. Bowman, M. Huang, S. Nam, I. Eweis, N. Diaz, D. Sullivan, et al.
Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells
Clin. Cancer Res., January 1, 2006; 12(1): 11 - 19.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. B. Haura, Z. Zheng, L. Song, A. Cantor, and G. Bepler
Activated Epidermal Growth Factor Receptor-Stat-3 Signaling Promotes Tumor Survival In vivo in Non-Small Cell Lung Cancer
Clin. Cancer Res., December 1, 2005; 11(23): 8288 - 8294.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. M. Pulukuri, C. S. Gondi, S. S. Lakka, A. Jutla, N. Estes, M. Gujrati, and J. S. Rao
RNA Interference-directed Knockdown of Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor Inhibits Prostate Cancer Cell Invasion, Survival, and Tumorigenicity in Vivo
J. Biol. Chem., October 28, 2005; 280(43): 36529 - 36540.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Q. Lin, R. Lai, L. R. Chirieac, C. Li, V. A. Thomazy, I. Grammatikakis, G. Z. Rassidakis, W. Zhang, Y. Fujio, K. Kunisada, et al.
Constitutive Activation of JAK3/STAT3 in Colon Carcinoma Tumors and Cell Lines: Inhibition of JAK3/STAT3 Signaling Induces Apoptosis and Cell Cycle Arrest of Colon Carcinoma Cells
Am. J. Pathol., October 1, 2005; 167(4): 969 - 980.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Turkson, S. Zhang, L. B. Mora, A. Burns, S. Sebti, and R. Jove
A Novel Platinum Compound Inhibits Constitutive Stat3 Signaling and Induces Cell Cycle Arrest and Apoptosis of Malignant Cells
J. Biol. Chem., September 23, 2005; 280(38): 32979 - 32988.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Gao, L. Zhang, J. Hu, F. Li, Y. Shao, D. Zhao, D. V. Kalvakolanu, D. J. Kopecko, X. Zhao, and D.-Q. Xu
Down-Regulation of Signal Transducer and Activator of Transcription 3 Expression Using Vector-Based Small Interfering RNAs Suppresses Growth of Human Prostate Tumor In vivo
Clin. Cancer Res., September 1, 2005; 11(17): 6333 - 6341.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
Z. Zheng, G. Bepler, A. Cantor, and E. B. Haura
Small Tumor Size and Limited Smoking History Predicts Activated Epidermal Growth Factor Receptor in Early-Stage Non-small Cell Lung Cancer
Chest, July 1, 2005; 128(1): 308 - 316.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Schlessinger and D. E. Levy
Malignant Transformation but not Normal Cell Growth Depends on Signal Transducer and Activator of Transcription 3
Cancer Res., July 1, 2005; 65(13): 5828 - 5834.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. V. Alvarez, P. G. Febbo, S. Ramaswamy, M. Loda, A. Richardson, and D. A. Frank
Identification of a Genetic Signature of Activated Signal Transducer and Activator of Transcription 3 in Human Tumors
Cancer Res., June 15, 2005; 65(12): 5054 - 5062.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
Z Culig, H Steiner, G Bartsch, and A Hobisch
Mechanisms of endocrine therapy-responsive and -unresponsive prostate tumours
Endocr. Relat. Cancer, June 1, 2005; 12(2): 229 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Song, R. Wang, S. Wang, and J. Lin
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
PNAS, March 29, 2005; 102(13): 4700 - 4705.
[Abstract] [Full Text] [PDF]

Home page
 Integr Cancer TherHome page
M. F. McCarty
Targeting Multiple Signaling Pathways as a Strategy for Managing Prostate Cancer: Multifocal Signal Modulation Therapy
Integr Cancer Ther, December 1, 2004; 3(4): 349 - 380.
[Abstract] [PDF]

Home page
 Cancer Res.Home page
M. Thomas, C. E. Finnegan, K. M.-A. Rogers, J. W. Purcell, A. Trimble, P. G. Johnston, and M. P. Boland
STAT1: A Modulator of Chemotherapy-induced Apoptosis
Cancer Res., November 15, 2004; 64(22): 8357 - 8364.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
V. J. Assikis, K.-A. Do, S. Wen, X. Wang, J. H. Cho-Vega, S. Brisbay, R. Lopez, C. J. Logothetis, P. Troncoso, C. N. Papandreou, et al.
Clinical and Biomarker Correlates of Androgen-Independent, Locally Aggressive Prostate Cancer with Limited Metastatic Potential
Clin. Cancer Res., October 15, 2004; 10(20): 6770 - 6778.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
B. E. Barton, T. F. Murphy, P. Shu, H. F. Huang, M. Meyenhofen, and A. Barton
Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines
Mol. Cancer Ther., October 1, 2004; 3(10): 1183 - 1191.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Jing, Y. Li, W. Xiong, W. Sha, L. Jing, and D. J. Tweardy
G-Quartet Oligonucleotides: A New Class of Signal Transducer and Activator of Transcription 3 Inhibitors That Suppresses Growth of Prostate and Breast Tumors through Induction of Apoptosis
Cancer Res., September 15, 2004; 64(18): 6603 - 6609.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
H. Siavash, N.G. Nikitakis, and J.J. Sauk
SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION: INSIGHTS INTO THE MOLECULAR BASIS OF ORAL CANCER
Critical Reviews in Oral Biology & Medicine, September 1, 2004; 15(5): 298 - 307.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
R. D. Read, E. A. Bach, and R. L. Cagan
Drosophila C-Terminal Src Kinase Negatively Regulates Organ Growth and Cell Proliferation through Inhibition of the Src, Jun N-Terminal Kinase, and STAT Pathways
Mol. Cell. Biol., August 1, 2004; 24(15): 6676 - 6689.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Li, T. J. Ahonen, K. Alanen, J. Xie, M. J. LeBaron, T. G. Pretlow, E. L. Ealley, Y. Zhang, M. Nurmi, B. Singh, et al.
Activation of Signal Transducer and Activator of Transcription 5 in Human Prostate Cancer Is Associated with High Histological Grade
Cancer Res., July 15, 2004; 64(14): 4774 - 4782.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Moroz, C. Eppolito, Q. Li, J. Tao, C. H. Clegg, and P. A. Shrikant
IL-21 Enhances and Sustains CD8+ T Cell Responses to Achieve Durable Tumor Immunity: Comparative Evaluation of IL-2, IL-15, and IL-21
J. Immunol., July 15, 2004; 173(2): 900 - 909.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. L. Silver, H. Naora, J. Liu, W. Cheng, and D. J. Montell
Activated Signal Transducer and Activator of Transcription (STAT) 3: Localization in Focal Adhesions and Function in Ovarian Cancer Cell Motility
Cancer Res., May 15, 2004; 64(10): 3550 - 3558.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Kim, R. M. Adam, K. R. Solomon, and M. R. Freeman
Involvement of Cholesterol-Rich Lipid Rafts in Interleukin-6-Induced Neuroendocrine Differentiation of LNCaP Prostate Cancer Cells
Endocrinology, February 1, 2004; 145(2): 613 - 619.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
B. E. Barton, J. G. Karras, T. F. Murphy, A. Barton, and H. F-S. Huang
Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines
Mol. Cancer Ther., January 1, 2004; 3(1): 11 - 20.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. He, L. You, K. Uematsu, K. Zang, Z. Xu, A. Y. Lee, J. F. Costello, F. McCormick, and D. M. Jablons
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
PNAS, November 25, 2003; 100(24): 14133 - 14138.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. W. Mandell
Phosphorylation State-Specific Antibodies: Applications in Investigative and Diagnostic Pathology
Am. J. Pathol., November 1, 2003; 163(5): 1687 - 1698.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. D. Khoury, L. J. Medeiros, G. Z. Rassidakis, M. A. Yared, P. Tsioli, V. Leventaki, A. Schmitt-Graeff, M. Herling, H. M. Amin, and R. Lai
Differential Expression and Clinical Significance of Tyrosine-phosphorylated STAT3 in ALK+ and ALK- Anaplastic Large Cell Lymphoma
Clin. Cancer Res., September 1, 2003; 9(10): 3692 - 3699.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.