Cancer Research AACR Legacy  Jordan
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Feltes, C. M.
Right arrow Articles by Byers, S. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Feltes, C. M.
Right arrow Articles by Byers, S. W.
[Cancer Research 62, 6688-6697, November 15, 2002]
© 2002 American Association for Cancer Research


Tumor Biology

An Alternatively Spliced Cadherin-11 Enhances Human Breast Cancer Cell Invasion1

Carolyn M. Feltes, Akira Kudo, Orest Blaschuk and Stephen W. Byers2

Lombardi Cancer Research Center and Departments of Oncology and Cell Biology, Georgetown University School of Medicine, Washington, D.C. 20007 [C. M. F., S. W. B.]; Department of Life Science, Tokyo Institute of Technology, Yokohama, 226-8501 Japan [A. K.]; and Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada H3A 1A1 [O. B.]

Although reduced levels of the epithelial cell adhesion molecule E-cadherin are often associated with poorly differentiated breast cancers, recent studies show that expression of other cadherins such as N-cadherin, P-cadherin, and the mesenchymal cadherin-11 is actually elevated in invasive breast cancers and cell lines. Cadherin-11 is unique among cadherins in that it exists as two alternatively spliced forms that are expressed together in the same cell. We now show that expression of wild-type cadherin-11, with or without coexpression of the COOH-terminal truncated splice variant, promotes epithelial differentiation of the cadherin-negative SKBR3 cell line. Exogenous wild-type cadherin-11 association with and membrane recruitment of ß-catenin and p120 are unaffected by coexpression of the truncated variant. Cadherin-11-expressing cells exhibit modest changes in cell proliferation and no change in anchorage-independent growth. However, coexpression of wild-type cadherin-11 and the splice variant promotes a dramatic increase in the ability of SKBR3 cells and E-cadherin-positive MCF7 cells to traverse Matrigel-coated filters. Biochemical studies indicate that the truncated variant may be secreted from the cell and/or enter a detergent-insoluble compartment. These data suggest that the presence of the cadherin-11 splice variant promotes invasion of cadherin-11-positive breast cancer cells.




This article has been cited by other articles:


Home page
Cancer Res.Home page
G. Agiostratidou, M. Li, K. Suyama, I. Badano, R. Keren, S. Chung, A. Anzovino, J. Hulit, B. Qian, B. Bouzahzah, et al.
Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis
Cancer Res., June 15, 2009; 69(12): 5030 - 5038.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
C. McCusker, H. Cousin, R. Neuner, and D. Alfandari
Extracellular Cleavage of Cadherin-11 by ADAM Metalloproteases Is Essential for Xenopus Cranial Neural Crest Cell Migration
Mol. Biol. Cell, January 1, 2009; 20(1): 78 - 89.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
Y. Shintani, Y. Fukumoto, N. Chaika, R. Svoboda, M. J. Wheelock, and K. R. Johnson
Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1
J. Cell Biol., March 24, 2008; 180(6): 1277 - 1289.
[Abstract] [Full Text] [PDF]


Home page
Neuro Oncol DukeHome page
S. de Bouard, P. Herlin, J. G. Christensen, E. Lemoisson, P. Gauduchon, E. Raymond, and J.-S. Guillamo
Antiangiogenic and anti-invasive effects of sunitinib on experimental human glioblastoma
Neuro-oncol, October 1, 2007; 9(4): 412 - 423.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
Y. Shintani, M. A. Hollingsworth, M. J. Wheelock, and K. R. Johnson
Collagen I Promotes Metastasis in Pancreatic Cancer by Activating c-Jun NH2-Terminal Kinase 1 and Up-regulating N-Cadherin Expression
Cancer Res., December 15, 2006; 66(24): 11745 - 11753.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
M. Yanagisawa and P. Z. Anastasiadis
p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness
J. Cell Biol., September 25, 2006; 174(7): 1087 - 1096.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
X. Q. Wang, J. M. Luk, M. Garcia-Barcelo, X. Miao, P. P. Leung, D. W. Ho, S. T. Cheung, B. Y. Lam, C. K. Cheung, A. S. Wong, et al.
Liver Intestine-Cadherin (CDH17) Haplotype Is Associated with Increased Risk of Hepatocellular Carcinoma
Clin. Cancer Res., September 1, 2006; 12(17): 5248 - 5252.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
H. Lei, A. H. Juan, M.-S. Kim, and F. H. Ruddle
Identification of a Hoxc8-regulated transcriptional network in mouse embryo fibroblast cells
PNAS, July 5, 2006; 103(27): 10305 - 10309.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
C. W. Rinker-Schaeffer, J. P. O'Keefe, D. R. Welch, and D. Theodorescu
Metastasis Suppressor Proteins: Discovery, Molecular Mechanisms, and Clinical Application.
Clin. Cancer Res., July 1, 2006; 12(13): 3882 - 3889.
[Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
X. Q. Wang, J. M. Luk, P. P. Leung, B. W. Wong, E. J. Stanbridge, and S. T. Fan
Alternative mRNA Splicing of Liver Intestine-Cadherin in Hepatocellular Carcinoma
Clin. Cancer Res., January 15, 2005; 11(2): 483 - 489.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. Paredes, C. Stove, V. Stove, F. Milanezi, V. Van Marck, L. Derycke, M. Mareel, M. Bracke, and F. Schmitt
P-Cadherin Is Up-Regulated by the Antiestrogen ICI 182,780 and Promotes Invasion of Human Breast Cancer Cells
Cancer Res., November 15, 2004; 64(22): 8309 - 8317.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
D. Ivanov, M. Philippova, R. Allenspach, P. Erne, and T. Resink
T-cadherin upregulation correlates with cell-cycle progression and promotes proliferation of vascular cells
Cardiovasc Res, October 1, 2004; 64(1): 132 - 143.
[Abstract] [Full Text] [PDF]


Home page
Mol Cancer ResHome page
M. N. Marchong, D. Chen, T. W. Corson, C. Lee, M. Harmandayan, E. Bowles, N. Chen, and B. L. Gallie
Minimal 16q Genomic Loss Implicates Cadherin-11 in Retinoblastoma
Mol. Cancer Res., September 1, 2004; 2(9): 495 - 503.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
T. Shibata, A. Kokubu, S. Sekine, Y. Kanai, and S. Hirohashi
Cytoplasmic p120ctn Regulates the Invasive Phenotypes of E-Cadherin-Deficient Breast Cancer
Am. J. Pathol., June 1, 2004; 164(6): 2269 - 2278.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
C. D. Hoang, J. D'Cunha, S. H. Tawfic, A. C. Gruessner, R. A. Kratzke, and M. A. Maddaus
Expression profiling of non-small cell lung carcinoma identifies metastatic genotypes based on lymph node tumor burden
J. Thorac. Cardiovasc. Surg., May 1, 2004; 127(5): 1332 - 1342.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. M. Oliveira, B.-L. Hsi, S. Weremowicz, A. E. Rosenberg, P. D. Cin, N. Joseph, J. A. Bridge, A. R. Perez-Atayde, and J. A. Fletcher
USP6 (Tre2) Fusion Oncogenes in Aneurysmal Bone Cyst
Cancer Res., March 15, 2004; 64(6): 1920 - 1923.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
Q. Xu and C. Lee
Discovery of novel splice forms and functional analysis of cancer-specific alternative splicing in human expressed sequences
Nucleic Acids Res., October 1, 2003; 31(19): 5635 - 5643.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
B. J. Katafiasz, M. T. Nieman, M. J. Wheelock, and K. R. Johnson
Characterization of Cadherin-24, a Novel Alternatively Spliced Type II Cadherin
J. Biol. Chem., July 18, 2003; 278(30): 27513 - 27519.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.