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Genetic Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel [A. B-S., U. R., M. G., Y. Y., A. O-U.]; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel [Y. Y., A. O-U.]; Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel [J. H. P., Z. E.]; and Department of Adult Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115 [W. R. S.]
We analyzed a prostate cancer xenograft derived from a locally advanced tumor using combined cytogenetic, array-based comparative genomic hybridization and expression analyses. This analysis revealed that genes in the 20q13 chromosomal region, CSE1L, ZNF217, MYBL2, and STK15, were significantly overexpressed in this tumor. The expression pattern of these genes was then confirmed in two large human prostate cancer microarray databases. Furthermore, the MYBL2 and STK15 have been significantly overexpressed in prostate metastases, allowing a clear distinction between localized tumors and metastases. Our data suggest these genes to be involved in advanced stages of prostate tumorigenesis and as such, they may serve as markers for tumor progression.
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