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Prognostic Importance of Glomeruloid Microvascular Proliferation Indicates an Aggressive Angiogenic Phenotype in Human Cancers¹

Department of Pathology, The Gade Institute, University of Bergen, Bergen 5021, Norway [O. S., H. B. S., O. J. H., L. A. A.]; Departments of Oncology, Medicine, and Research Institute of the McGill University Health Centre Canada H3G 1A4 [P. O. C., J. R. G., W. D. F.], Departments of Pathology and Surgery [L. R. B.], and Program in Cancer Genetics and Cancer Prevention Centre, Sir M. B. Davis-Jewish General Hospital [W. D. F.], McGill University, Montreal, Quebec, Canada H3T 1E2; and Department of Gynecology and Obstetrics [H. B. S.] and Department of Surgery, Section of Urology [S. A. H.], University of Bergen, Bergen N-5021, Norway

We evaluated the presence of glomeruloid microvascular proliferations (GMPs) in 723 patients with melanomas, breast, endometrial, or prostate cancer. Presence of GMPs was associated with markers of aggressive tumor behavior and significantly reduced survival or increased clinical recurrences in all four of the cancer types in univariate analysis. GMPs were related to increased microvessel density in prostate cancer only. In the case of melanomas, breast, and prostate cancers (but not endometrial cancers), GMPs were a significant prognostic factor in the final multivariate models (P all 0.02), and was a better predictor of outcome than was microvessel density. In conclusion, GMPs might indicate a more aggressive vascular phenotype associated with poor prognosis and could be a novel prognostic marker in human cancer.

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