Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention AACR Conference on Molecular Diagnostics - 2008
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[Cancer Research 62, 6846-6849, December 1, 2002]
© 2002 American Association for Cancer Research

Carcinogenesis

Cyclooxygenase-2 Expression in Fibroblasts and Endothelial Cells of Intestinal Polyps1

Masahiro Sonoshita, Kazuaki Takaku, Masanobu Oshima, Ken-ichi Sugihara and Makoto M. Taketo2

Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501 [M. S., K. T., M. O., M. M. T.], and Department of Digestive Surgery, Tokyo Medical and Dental University, Tokyo 113-8519 [K-i. S.], Japan

Cyclooxygenase-2 (COX-2), the inducible COX isozyme, plays a key role in intestinal tumorigenesis. We have demonstrated recently that COX-2 protein is induced in the polyp stroma near the intestinal luminal surface in the Apc{Delta}716 mouse, a model for human familial adenomatous polyposis, and stimulate tumor angiogenesis. However, the precise cell types that express COX-2 are still to be determined. By immunohistochemical analysis, here we show that the majority of COX-2-expressing cells in the intestinal polyps of Apc{Delta}716 mice are fibroblasts and endothelial cells. Furthermore, the COX-2-expressing cells in human familial adenomatous polyposis polyps are also fibroblasts and endothelial cells. In contrast, bone marrow-derived cells such as macrophages and leukocytes express little COX-2 protein in the intestinal polyps. These results clearly indicate that fibroblasts and endothelial cells play important roles in polyp expansion by expressing COX-2, resulting in tumor angiogenesis.




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