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[Cancer Research 62, 7001-7003, December 1, 2002]
© 2002 American Association for Cancer Research

Molecular Biology and Genetics

Missense Mutations of the BRAF Gene in Human Lung Adenocarcinoma1

Katsuhiko Naoki, Tzu-Hsiu Chen, William G. Richards, David J. Sugarbaker and Matthew Meyerson2

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115 [K. N., T-H. C., M. M.], and Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115 [W. G. R., D. J. S.]

Mutations of the BRAF protein serine/threonine kinase gene have recently been identified in a variety of human cancers, most notably melanomas. We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis. Analysis of BRAF sequence from 127 primary human lung adenocarcinomas revealed mutations in two tumor specimens, one in exon 11 (G465V), and a second in exon 15 (L596R). These specimens belong to the same adenocarcinoma subgroup as defined by clustering of gene expression data. BRAF may provide a target for anticancer chemotherapy in a subset of lung adenocarcinoma patients.




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