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[Cancer Research 62, 7012-7017, December 1, 2002]
© 2002 American Association for Cancer Research

Molecular Biology and Genetics

Genome-Wide Analysis of Gene Expression in Intestinal-Type Gastric Cancers Using a Complementary DNA Microarray Representing 23,040 Genes1

Suguru Hasegawa, Yoichi Furukawa, Meihua Li, Seiji Satoh, Tatsushi Kato, Takeshi Watanabe, Toyomasa Katagiri, Tatsuhiko Tsunoda, Yoshio Yamaoka and Yusuke Nakamura2

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan [S. H., Y. F., M. L., T. Kato, T. W., T. Kata., Y. N.], Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan [S. H., S. S., T. Kato, T. W., Y. Y.]; and Laboratory for Medical Informatics, SNP Research Center, Riken (Institute of Physical and Chemical Research), Tokyo, Japan [T. T.]

To shed light on mechanisms that underlie development and/or progression of intestinal-type gastric cancer, we compared expression profiles of cancer cells obtained by laser-capture microdissection of 20 intestinal-type gastric tumors with expression of genes in corresponding noncancerous mucosae, by a cDNA microarray consisting of 23,040 genes. We identified 61 genes that were commonly up-regulated and 63 that were commonly down-regulated in the cancer tissues. Altered expression of 12 of those genes was associated with lymph node metastasis. A "predictive score," based on expression profiles of five of the genes that were able to distinguish tumors with metastasis from node-negative tumors in our panel, correctly diagnosed the lymph node status of nine additional gastric cancers. This genome-wide information contributes to an improved understanding of molecular changes during the development of intestinal-type gastric cancers. It may help clinicians predict metastasis to lymph nodes and assist researchers in identifying novel therapeutic targets for this type of cancer.




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