| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Tumor Biology |
Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122 [S. E., L. D. V., C. L., D-D. G., K. K.]; Departmento de Patologia, The American British Cowdray Medical Center I. A. P., México D.F., México 01120 [C. O-H.]; and Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107 [J. P. P.]
Infection of the gastrointestinal tract by the human polyomavirus, JCV, which has been frequently detected in raw urban sewage, can occur via intake of contaminated water and food. In light of earlier reports on the tumorigenecity of JCV, we investigated the presence of the JCV genome and the expression of viral proteins in a collection of 27 well-characterized epithelial malignant tumors of the large intestine. Results from gene amplification revealed the presence of the viral early genome in 22 of 27 samples. Expression of the viral oncogenic early protein, T-antigen, and the late auxiliary protein, Agnoprotein, was observed in >50% of the samples. The absence of the viral capsid protein in the tumor cells excludes productive replication of the virus in neoplastic cells. Laser capture microdissection confirmed the presence of the JCV genome and expression of T-antigen in precancerous villous adenomas and regions of invasive adenocarcinoma. The ability of JCV T-antigen to interact with ß-catenin and the nuclear detection of ß-catenin in T-antigen-positive cells suggests dysregulation of the Wnt pathway in the tumor cells. The coproduction of T-antigen and ß-catenin in colon cancer cells enhanced transcription of the c-myc promoter, the downstream target of ß-catenin. These observations provide evidence for a possible association of JCV with colon cancer and suggest a novel regulatory role for T-antigen in the deregulation of the Wnt signaling pathway through ß-catenin in tumors of the gastrointestinal tract.
This article has been cited by other articles:
|
|
 |
|
  J. A. Vanchiere, S. Abudayyeh, C. M. Copeland, L. B. Lu, D. Y. Graham, and J. S. Butel Polyomavirus Shedding in the Stool of Healthy Adults J. Clin. Microbiol., August 1, 2009; 47(8): 2388 - 2391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Rollison, K. J. Helzlsouer, J.-H. Lee, W. Fulp, S. Clipp, J. A. Hoffman-Bolton, A. R. Giuliano, E. A. Platz, and R. P. Viscidi Prospective Study of JC Virus Seroreactivity and the Development of Colorectal Cancers and Adenomas Cancer Epidemiol. Biomarkers Prev., May 1, 2009; 18(5): 1515 - 1523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Burnett-Hartman, P. A. Newcomb, and J. D. Potter Infectious Agents and Colorectal Cancer: A Review of Helicobacter pylori, Streptococcus bovis, JC Virus, and Human Papillomavirus Cancer Epidemiol. Biomarkers Prev., November 1, 2008; 17(11): 2970 - 2979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Selgrad, J. J. Koornstra, L. Fini, M. Blom, R. Huang, E. B. DeVol, W. Boersma-van Ek, G. Dijkstra, R. C. Verdonk, S. de Jong, et al. JC Virus Infection in Colorectal Neoplasia That Develops after Liver Transplantation Clin. Cancer Res., October 15, 2008; 14(20): 6717 - 6721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zheng, Y. Murai, M. Hong, Y. Nakanishi, K. Nomoto, S. Masuda, K. Tsuneyama, and Y. Takano Jamestown Canyon virus detection in human tissue specimens J. Clin. Pathol., July 1, 2007; 60(7): 787 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tomita, A. Kikuchi, T. Akiyama, Y. Tanaka, and N. Mori Human T-Cell Leukemia Virus Type 1 Tax Dysregulates {beta}-Catenin Signaling J. Virol., November 1, 2006; 80(21): 10497 - 10505. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C R Boland, M G Luciani, C Gasche, and A Goel INFECTION, INFLAMMATION, AND GASTROINTESTINAL CANCER Gut, September 1, 2005; 54(9): 1321 - 1331. [Full Text] [PDF]
|
|
|
|
|
|
C. R. Boland, J. Bigler, P. A. Newcomb, J. W. Lampe, and J. D. Potter Evidence for an Association between JC Virus and Colorectal Neoplasia Cancer Epidemiol. Biomarkers Prev., December 1, 2004; 13(12): 2285 - 2286. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Shackelford and J. S. Pagano Tumor Viruses and Cell Signaling Pathways: Deubiquitination versus Ubiquitination Mol. Cell. Biol., June 15, 2004; 24(12): 5089 - 5093. [Full Text] [PDF]
|
|
|
|
|
|
P. A. Newcomb, A. C. Bush, G. L. Stoner, J. W. Lampe, J. D. Potter, and J. Bigler No Evidence of an Association of JC Virus and Colon Neoplasia Cancer Epidemiol. Biomarkers Prev., April 1, 2004; 13(4): 662 - 666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Ricciardiello, M. Baglioni, C. Giovannini, M. Pariali, G. Cenacchi, A. Ripalti, M. P. Landini, H. Sawa, K. Nagashima, R. J. Frisque, et al. Induction of Chromosomal Instability in Colonic Cells by the Human Polyomavirus JC Virus Cancer Res., November 1, 2003; 63(21): 7256 - 7262. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
