| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Tumor Biology |
Division of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California 94720 [J. M., D. L., R. B., M. J. B.], and Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa 52242 [M. H., K. C.]
Receptors mediating cell-basement membrane interactions are potent regulators of epithelial architecture and function, and alterations in signals from the basement membrane are implicated in the aberrant behavior of carcinoma cells. In this study, we have investigated the role of the basement membrane receptor dystroglycan (DG) in mammary epithelial cell function, and the significance of loss of DG function in breast tumor cell lines. Nonmalignant mammary epithelial cells express a functional DG. Analysis of multiple breast carcinoma cell lines revealed that DG is expressed in all of the cell lines examined, as evidenced by ß-DG expression, but that 
-DG is functionally diminished in the majority. High levels of -DG correlated strongly with the ability of cells to polarize in the presence of the basement membrane. Overexpression of the DG cDNA in HMT-3522-T4-2 cells elevated -DG levels and altered responsiveness to the basement membrane; DG overexpression restored the ability of the cells to undergo cytoskeletal changes, to polarize, and to restrict growth in response to basement membrane proteins. Moreover, restoration of DG function to these cells greatly reduced their tumorigenic potential in nude mice. These data point to DG as an important mediator of normal cell responses to the basement membrane, and as a significant variable in carcinoma cells, in which its frequent loss can contribute to aberrant cell behavior.
This article has been cited by other articles:
|
|
 |
|
  Y. Gong, R. Zhang, J. Zhang, L. Xu, F. Zhang, W. Xu, Y. Wang, Y. Chu, and S. Xiong {alpha}-Dystroglycan is involved in positive selection of thymocytes by participating in immunological synapse formation FASEB J, May 1, 2008; 22(5): 1426 - 1439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rizki, V. M. Weaver, S.-Y. Lee, G. I. Rozenberg, K. Chin, C. A. Myers, J. L. Bascom, J. D. Mott, J. R. Semeiks, L. R. Grate, et al. A Human Breast Cell Model of Preinvasive to Invasive Transition Cancer Res., March 1, 2008; 68(5): 1378 - 1387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Yatsenko, E. E. Gray, H. R. Shcherbata, L. B. Patterson, V. D. Sood, M. M. Kucherenko, D. Baker, and H. Ruohola-Baker A Putative Src Homology 3 Domain Binding Motif but Not the C-terminal Dystrophin WW Domain Binding Motif Is Required for Dystroglycan Function in Cellular Polarity in Drosophila J. Biol. Chem., May 18, 2007; 282(20): 15159 - 15169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hnia, G. Hugon, F. Rivier, A. Masmoudi, J. Mercier, and D. Mornet Modulation of p38 Mitogen-Activated Protein Kinase Cascade and Metalloproteinase Activity in Diaphragm Muscle in Response to Free Radical Scavenger Administration in Dystrophin-Deficient Mdx Mice Am. J. Pathol., February 1, 2007; 170(2): 633 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Yao, H. Zhang, Y.-Y. Chen, B. Lee, K. Chew, D. Moore, and C. Park Increased {beta}1 Integrin Is Associated with Decreased Survival in Invasive Breast Cancer Cancer Res., January 15, 2007; 67(2): 659 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Watanabe, T. Sasaoka, S. Noguchi, I. Nishino, and T. Tanaka Cys669-Cys713 disulfide bridge formation is a key to dystroglycan cleavage and subunit association. Genes Cells, January 1, 2007; 12(1): 75 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Weir, M. L. Oppizzi, M. D. Henry, A. Onishi, K. P. Campbell, M. J. Bissell, and J. L. Muschler Dystroglycan loss disrupts polarity and {beta}-casein induction in mammary epithelial cells by perturbing laminin anchoring J. Cell Sci., October 1, 2006; 119(19): 4047 - 4058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schneider, A. A. Khalil, J. Poulton, C. Castillejo-Lopez, D. Egger-Adam, A. Wodarz, W.-M. Deng, and S. Baumgartner Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization Development, October 1, 2006; 133(19): 3805 - 3815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. DeBiase, K. Lane, S. Budinger, K. Ridge, M. Wilson, and J. C.R. Jones Laminin-311 (Laminin-6) Fiber Assembly by Type I-like Alveolar Cells J. Histochem. Cytochem., June 1, 2006; 54(6): 665 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Driss, L. Charrier, Y. Yan, V. Nduati, S. Sitaraman, and D. Merlin Dystroglycan receptor is involved in integrin activation in intestinal epithelia Am J Physiol Gastrointest Liver Physiol, June 1, 2006; 290(6): G1228 - G1242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Johnson, S. H. Kang, and J. M. Kramer C. elegans dystroglycan DGN-1 functions in epithelia and neurons, but not muscle, and independently of dystrophin Development, May 15, 2006; 133(10): 1911 - 1921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Tremblay and S. Carbonetto An Extracellular Pathway for Dystroglycan Function in Acetylcholine Receptor Aggregation and Laminin Deposition in Skeletal Myotubes J. Biol. Chem., May 12, 2006; 281(19): 13365 - 13373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Barresi and K. P. Campbell Dystroglycan: from biosynthesis to pathogenesis of human disease J. Cell Sci., January 15, 2006; 119(2): 199 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. R. Jones, K. Lane, S. B. Hopkinson, E. Lecuona, R. C. Geiger, D. A. Dean, E. Correa-Meyer, M. Gonzales, K. Campbell, J. I. Sznajder, et al. Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism J. Cell Sci., June 15, 2005; 118(12): 2557 - 2566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Patnaik and P. Stanley Mouse Large Can Modify Complex N- and Mucin O-Glycans on {alpha}-Dystroglycan to Induce Laminin Binding J. Biol. Chem., May 27, 2005; 280(21): 20851 - 20859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Singh, Y. Itahana, S. Knight-Krajewski, M. Kanagawa, K. P. Campbell, M. J. Bissell, and J. Muschler Proteolytic Enzymes and Altered Glycosylation Modulate Dystroglycan Function in Carcinoma Cells Cancer Res., September 1, 2004; 64(17): 6152 - 6159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Novaro, C. D. Roskelley, and M. J. Bissell Collagen-IV and laminin-1 regulate estrogen receptor {alpha} expression and function in mouse mammary epithelial cells J. Cell Sci., July 15, 2003; 116(14): 2975 - 2986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Schmeichel and M. J. Bissell Modeling tissue-specific signaling and organ function in three dimensions J. Cell Sci., June 15, 2003; 116(12): 2377 - 2388. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
