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[Cancer Research 62, 7170-7174, December 15, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

Induction of Glioblastoma Apoptosis Using Neural Stem Cell-mediated Delivery of Tumor Necrosis Factor-related Apoptosis-inducing Ligand1

Moneeb Ehtesham, Peter Kabos, Mervin A. R. Gutierrez, Nancy H. C. Chung, Thomas S. Griffith, Keith L. Black and John S. Yu2

Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048 [M. E., P. K., M. A. R. G., N. H. C. C., K. L. B., J. S. Y.] and Department of Surgery, University of Iowa School of Medicine, Iowa City, Iowa 52242 [T. S. G.]

Current therapies for gliomas fail to address their highly infiltrative nature. Standard treatments oftenleave behind microscopic neoplastic reservoirs, resulting in eventual tumor recurrence. Neural stem cells (NSCs) are capable of tracking disseminating glioma cells. To exploit this tropism to develop a therapeutic strategy that targeted tumor satellites, we inoculated human glioblastoma xenografts with tumor necrosis factor-related apoptosis-inducing ligand-secreting NSCs. This resulted in the dramatic induction of apoptosis in treated tumors and tumor satellites and was associated with significant inhibition of tumor growth. These results add credence to the potential of NSCs as therapeutically effective delivery vehicles for the treatment of intracranial glioma.




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