Cancer Research The Future of Cancer Research: Science and Patient Impact AACR Conference on Molecular Diagnostics - 2008
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ang, K. K.
Right arrow Articles by Milas, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ang, K. K.
Right arrow Articles by Milas, L.
[Cancer Research 62, 7350-7356, December 15, 2002]
© 2002 American Association for Cancer Research

Tumor Biology

Impact of Epidermal Growth Factor Receptor Expression on Survival and Pattern of Relapse in Patients with Advanced Head and Neck Carcinoma1

K. Kian Ang2, Brian A. Berkey, Xiaoyu Tu, Hua-Zhong Zhang, Ruth Katz, Elizabeth H. Hammond, Karen K. Fu and Luka Milas

Departments of Radiation Oncology [K. K. A.], Experimental Radiation Oncology [X. T., L. M.], Anatomical Pathology Services Cytology [H-Z. Z.], and Pathology–Patient Care [R. K.] and Radiation Therapy Oncology Group [B. A. B.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030; Department of Pathology, LDS Hospital, University of Utah School of Medicine, Salt Lake City, Utah 84143 [E. H. H.]; and Department of Radiation Oncology, University of California, San Francisco, California 94143 [K. K. F.]

A correlative study was performed to address the impact of epidermal growth factor receptor (EGFR) overexpression on survival and pattern of failure in patients with advanced head and neck squamous cell carcinomas (HNSCCs) enrolled in a Phase III trial and randomized to receive conventional radiotherapy. The study population comprised 155 of 268 (58%) randomized patients with sufficient pretreatment biopsy specimens for immunohistochemical assay. The specimens were dewaxed and incubated after standard preparation with mouse monoclonal antibodies recognizing the extracellular domain of the EGFR molecule. The catalyzed product was visualized with 3,3'-diaminobenzidine Chromogen Kit and lightly counterstained with Mayer’s hematoxylin. Quantitative EGFR immunohistochemistry (IHC) was done with SAMBA 4000 Cell Image Analysis System, without knowledge of the clinical outcome, to yield mean absorbance (MOD), staining index (SI), and quick score (QS). These EGFR IHC parameters were correlated with the T stage, N stage, combined stage grouping, and recursive partitioning analysis classes. Subsequently, the EGFR parameters were correlated with the outcome end points, i.e., overall survival (OS), disease-free survival (DFS), local-regional (LR) relapse, and distant metastasis rates. We found that HNSCCs exhibited a wide variation in EGFR expression (MOD, 0.2–66.0; SI, 0.3–97.0; QS, 0.01–69.9) with a relatively strong but nonlinear correlation between MOD and SI (r = 0.79). There was no correlation between EGFR expression and T stage, N stage, stage grouping, and recursive partitioning analysis classes (r = -0.07 to 0.17). The OS and DFS rates of patients with high EGFR-expressing HNSCCs (>median MOD) were highly significantly lower (P = 0.0006 and P = 0.0016, respectively) and the LR relapse rate was highly significantly higher (P = 0.0031) compared with those of patients with low EGFR-expressing HNSCCs. However, there was no difference in the distant metastasis rate between the two groups (P = 0.96). Significant correlations, although somewhat less robust than MOD, were also observed between SI and QS and the OS, DFS, and LR relapse rates. Multivariate analysis showed that EGFR expression was an independent determinant of survival and a robust independent predictor of LR relapse. In summary, this correlative study in a large series of patients revealed that EGFR expression, which varied considerably among HNSCCs, was a strong independent prognostic indicator for OS and DFS and a robust predictor for LR relapse but not for distant metastasis. The data suggest that EGFR IHC should be considered for selecting patients for more aggressive combined therapies or enrollment into trials targeting EGFR signaling pathways.




This article has been cited by other articles:


Home page
 Arch Otolaryngol Head Neck SurgHome page
I. M. G. Agra, A. L. Carvalho, C. A. L. Pinto, E. P. Martins, J. G. Filho, F. A. Soares, and L. P. Kowalski
Biological Markers and Prognosis in Recurrent Oral Cancer After Salvage Surgery
Arch Otolaryngol Head Neck Surg, July 1, 2008; 134(7): 743 - 749.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. Koppikar, S.-H. Choi, A. M. Egloff, Q. Cai, S. Suzuki, M. Freilino, H. Nozawa, S. M. Thomas, W. E. Gooding, J. M. Siegfried, et al.
Combined Inhibition of c-Src and Epidermal Growth Factor Receptor Abrogates Growth and Invasion of Head and Neck Squamous Cell Carcinoma
Clin. Cancer Res., July 1, 2008; 14(13): 4284 - 4291.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. P. Melancon, W. Lu, Z. Yang, R. Zhang, Z. Cheng, A. M. Elliot, J. Stafford, T. Olson, J. Z. Zhang, and C. Li
In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy
Mol. Cancer Ther., June 1, 2008; 7(6): 1730 - 1739.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. L. Boehm, M. Sen, R. Seethala, W. E. Gooding, M. Freilino, S. M. Y. Wong, S. Wang, D. E. Johnson, and J. R. Grandis
Combined Targeting of Epidermal Growth Factor Receptor, Signal Transducer and Activator of Transcription-3, and Bcl-XL Enhances Antitumor Effects in Squamous Cell Carcinoma of the Head and Neck
Mol. Pharmacol., June 1, 2008; 73(6): 1632 - 1642.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. R. Seethala, W. E. Gooding, P. N. Handler, B. Collins, Q. Zhang, J. M. Siegfried, and J. R. Grandis
Immunohistochemical Analysis of Phosphotyrosine Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor Autocrine Signaling Pathways in Head and Neck Cancers and Metastatic Lymph Nodes
Clin. Cancer Res., March 1, 2008; 14(5): 1303 - 1309.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
S. Choi and J.N. Myers
Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy
J. Dent. Res., January 1, 2008; 87(1): 14 - 32.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. M. Roda, T. Joshi, J. P. Butchar, J. W. McAlees, A. Lehman, S. Tridandapani, and W. E. Carson III
The Activation of Natural Killer Cell Effector Functions by Cetuximab-Coated, Epidermal Growth Factor Receptor Positive Tumor Cells is Enhanced By Cytokines
Clin. Cancer Res., November 1, 2007; 13(21): 6419 - 6428.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
O. Riesterer, L. Milas, and K. K. Ang
Use of Molecular Biomarkers for Predicting the Response to Radiotherapy With or Without Chemotherapy
J. Clin. Oncol., September 10, 2007; 25(26): 4075 - 4083.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. Elser, L. L. Siu, E. Winquist, M. Agulnik, G. R. Pond, S. F. Chin, P. Francis, R. Cheiken, J. Elting, A. McNabola, et al.
Phase II Trial of Sorafenib in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck or Nasopharyngeal Carcinoma
J. Clin. Oncol., August 20, 2007; 25(24): 3766 - 3773.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
M. V. Karamouzis, J. R. Grandis, and A. Argiris
Therapies Directed Against Epidermal Growth Factor Receptor in Aerodigestive Carcinomas
JAMA, July 4, 2007; 298(1): 70 - 82.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. A. Forastiere and B. A. Burtness
Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer--More Insights, but More Questions
J. Clin. Oncol., June 1, 2007; 25(16): 2152 - 2155.
[Full Text] [PDF]

Home page
 JCOHome page
S. Temam, H. Kawaguchi, A. K. El-Naggar, J. Jelinek, H. Tang, D. D. Liu, W. Lang, J.-P. Issa, J. J. Lee, and L. Mao
Epidermal Growth Factor Receptor Copy Number Alterations Correlate With Poor Clinical Outcome in Patients With Head and Neck Squamous Cancer
J. Clin. Oncol., June 1, 2007; 25(16): 2164 - 2170.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. B. Vermorken, J. Trigo, R. Hitt, P. Koralewski, E. Diaz-Rubio, F. Rolland, R. Knecht, N. Amellal, A. Schueler, and J. Baselga
Open-Label, Uncontrolled, Multicenter Phase II Study to Evaluate the Efficacy and Toxicity of Cetuximab As a Single Agent in Patients With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck Who Failed to Respond to Platinum-Based Therapy
J. Clin. Oncol., June 1, 2007; 25(16): 2171 - 2177.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. L. Siu, D. Soulieres, E. X. Chen, G. R. Pond, S. F. Chin, P. Francis, L. Harvey, M. Klein, W. Zhang, J. Dancey, et al.
Phase I/II Trial of Erlotinib and Cisplatin in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: A Princess Margaret Hospital Phase II Consortium and National Cancer Institute of Canada Clinical Trials Group Study
J. Clin. Oncol., June 1, 2007; 25(16): 2178 - 2183.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. Curran, J. Giralt, P. M. Harari, K. K. Ang, R. B. Cohen, M. S. Kies, J. Jassem, J. Baselga, E. K. Rowinsky, N. Amellal, et al.
Quality of Life in Head and Neck Cancer Patients After Treatment With High-Dose Radiotherapy Alone or in Combination With Cetuximab
J. Clin. Oncol., June 1, 2007; 25(16): 2191 - 2197.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Y. Feng, C. A. Lopez, D. P. Normolle, S. Varambally, X. Li, P. Y. Chun, M. A. Davis, T. S. Lawrence, and M. K. Nyati
Effect of Epidermal Growth Factor Receptor Inhibitor Class in the Treatment of Head and Neck Cancer with Concurrent Radiochemotherapy In vivo
Clin. Cancer Res., April 15, 2007; 13(8): 2512 - 2518.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
J. Cruz, A Ocana, E Del Barco, and A Pandiella
Targeting receptor tyrosine kinases and their signal transduction routes in head and neck cancer
Ann. Onc., March 1, 2007; 18(3): 421 - 430.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
S-H. Ou, J. Zell, A Ziogas, and H Anton-Culver
Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology
Ann. Onc., January 1, 2007; 18(1): 29 - 35.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. C. Sok, F. M. Coppelli, S. M. Thomas, M. N. Lango, S. Xi, J. L. Hunt, M. L. Freilino, M. W. Graner, C. J. Wikstrand, D. D. Bigner, et al.
Mutant Epidermal Growth Factor Receptor (EGFRvIII) Contributes to Head and Neck Cancer Growth and Resistance to EGFR Targeting
Clin. Cancer Res., September 1, 2006; 12(17): 5064 - 5073.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
B. M. Tijink, D. Neri, C. R. Leemans, M. Budde, L. M. Dinkelborg, M. Stigter-van Walsum, L. Zardi, and G. A.M.S. van Dongen
Radioimmunotherapy of Head and Neck Cancer Xenografts Using 131I-Labeled Antibody L19-SIP for Selective Targeting of Tumor Vasculature
J. Nucl. Med., July 1, 2006; 47(7): 1127 - 1135.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
P P Dendy and P Wardman
Hypoxia in biology and medicine: the legacy of L H Gray.
Br. J. Radiol., July 1, 2006; 79(943): 545 - 549.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Erjala, M. Sundvall, T. T. Junttila, N. Zhang, M. Savisalo, P. Mali, J. Kulmala, J. Pulkkinen, R. Grenman, and K. Elenius
Signaling via ErbB2 and ErbB3 Associates with Resistance and Epidermal Growth Factor Receptor (EGFR) Amplification with Sensitivity to EGFR Inhibitor Gefitinib in Head and Neck Squamous Cell Carcinoma Cells.
Clin. Cancer Res., July 1, 2006; 12(13): 4103 - 4111.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. Bourhis, F. Rivera, R. Mesia, A. Awada, L. Geoffrois, C. Borel, Y. Humblet, A. Lopez-Pousa, R. Hitt, M. E. Vega Villegas, et al.
Phase I/II Study of Cetuximab in Combination With Cisplatin or Carboplatin and Fluorouracil in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
J. Clin. Oncol., June 20, 2006; 24(18): 2866 - 2872.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. M. Brizel and R. Esclamado
Concurrent Chemoradiotherapy for Locally Advanced, Nonmetastatic, Squamous Carcinoma of the Head and Neck: Consensus, Controversy, and Conundrum
J. Clin. Oncol., June 10, 2006; 24(17): 2612 - 2617.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. Bernier, J. B. Vermorken, and W. M. Koch
Adjuvant Therapy in Patients With Resected Poor-Risk Head and Neck Cancer
J. Clin. Oncol., June 10, 2006; 24(17): 2629 - 2635.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. E.W. Cohen
Role of Epidermal Growth Factor Receptor Pathway-Targeted Therapy in Patients With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck
J. Clin. Oncol., June 10, 2006; 24(17): 2659 - 2665.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
H. R. Cardenes, E. G. Chiorean, J. DeWitt, M. Schmidt, and P. Loehrer
Locally advanced pancreatic cancer: current therapeutic approach.
Oncologist, June 1, 2006; 11(6): 612 - 623.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
B. A. Conley
Treatment of Advanced Head and Neck Cancer: What Lessons Have We Learned?
J. Clin. Oncol., March 1, 2006; 24(7): 1023 - 1025.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Kong, P. Leboucher, R. Leek, V. Calleja, S. Winter, A. Harris, P. J. Parker, and B. Larijani
Prognostic value of an activation state marker for epidermal growth factor receptor in tissue microarrays of head and neck cancer.
Cancer Res., March 1, 2006; 66(5): 2834 - 2843.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Zhu, H. J. Belmont, S. Price-Schiavi, B. Liu, H.-i. Lee, M. Fernandez, R. L. Wong, J. Builes, P. R. Rhode, and H. C. Wong
Visualization of p53264-272/HLA-A*0201 Complexes Naturally Presented on Tumor Cell Surface by a Multimeric Soluble Single-Chain T Cell Receptor.
J. Immunol., March 1, 2006; 176(5): 3223 - 3232.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. A. Bonner, P. M. Harari, J. Giralt, N. Azarnia, D. M. Shin, R. B. Cohen, C. U. Jones, R. Sur, D. Raben, J. Jassem, et al.
Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck
N. Engl. J. Med., February 9, 2006; 354(6): 567 - 578.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M.-H. Yang, W.-C. Chiang, T.-Y. Chou, S.-Y. Chang, P.-M. Chen, S.-C. Teng, and K.-J. Wu
Increased NBS1 Expression Is a Marker of Aggressive Head and Neck Cancer and Overexpression of NBS1 Contributes to Transformation
Clin. Cancer Res., January 15, 2006; 12(2): 507 - 515.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. M. Erovic, M. Pelzmann, M. Ch. Grasl, J. Pammer, G. Kornek, W. Brannath, E. Selzer, and D. Thurnher
Mcl-1, Vascular Endothelial Growth Factor-R2, and 14-3-3{sigma} Expression Might Predict Primary Response against Radiotherapy and Chemotherapy in Patients with Locally Advanced Squamous Cell Carcinomas of the Head and Neck
Clin. Cancer Res., December 15, 2005; 11(24): 8632 - 8636.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
B. Burtness, M. A. Goldwasser, W. Flood, B. Mattar, and A. A. Forastiere
Phase III Randomized Trial of Cisplatin Plus Placebo Compared With Cisplatin Plus Cetuximab in Metastatic/Recurrent Head and Neck Cancer: An Eastern Cooperative Oncology Group Study
J. Clin. Oncol., December 1, 2005; 23(34): 8646 - 8654.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. E.W. Cohen, M. W. Lingen, L. E. Martin, P. L. Harris, B. W. Brannigan, S. M. Haserlat, R. A. Okimoto, D. C. Sgroi, S. Dahiya, B. Muir, et al.
Response of Some Head and Neck Cancers to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors May Be Linked to Mutation of ERBB2 rather than EGFR
Clin. Cancer Res., November 15, 2005; 11(22): 8105 - 8108.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. M. Bentzen, B. M. Atasoy, F. M. Daley, S. Dische, P. I. Richman, M. I. Saunders, K. R. Trott, and G. D. Wilson
Epidermal Growth Factor Receptor Expression in Pretreatment Biopsies From Head and Neck Squamous Cell Carcinoma As a Predictive Factor for a Benefit From Accelerated Radiation Therapy in a Randomized Controlled Trial
J. Clin. Oncol., August 20, 2005; 23(24): 5560 - 5567.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. S. Herbst, M. Arquette, D. M. Shin, K. Dicke, E. E. Vokes, N. Azarnia, W. K. Hong, and M. S. Kies
Phase II Multicenter Study of the Epidermal Growth Factor Receptor Antibody Cetuximab and Cisplatin for Recurrent and Refractory Squamous Cell Carcinoma of the Head and Neck
J. Clin. Oncol., August 20, 2005; 23(24): 5578 - 5587.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. Baselga, J. M. Trigo, J. Bourhis, J. Tortochaux, H. Cortes-Funes, R. Hitt, P. Gascon, N. Amellal, A. Harstrick, and A. Eckardt
Phase II Multicenter Study of the Antiepidermal Growth Factor Receptor Monoclonal Antibody Cetuximab in Combination With Platinum-Based Chemotherapy in Patients With Platinum-Refractory Metastatic and/or Recurrent Squamous Cell Carcinoma of the Head and Neck
J. Clin. Oncol., August 20, 2005; 23(24): 5568 - 5577.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Psyrri, Z. Yu, P. M. Weinberger, C. Sasaki, B. Haffty, R. Camp, D. Rimm, and B. A. Burtness
Quantitative Determination of Nuclear and Cytoplasmic Epidermal Growth Factor Receptor Expression in Oropharyngeal Squamous Cell Cancer by Using Automated Quantitative Analysis
Clin. Cancer Res., August 15, 2005; 11(16): 5856 - 5862.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Chinnaiyan, S. Huang, G. Vallabhaneni, E. Armstrong, S. Varambally, S. A. Tomlins, A. M. Chinnaiyan, and P. M. Harari
Mechanisms of Enhanced Radiation Response following Epidermal Growth Factor Receptor Signaling Inhibition by Erlotinib (Tarceva)
Cancer Res., April 15, 2005; 65(8): 3328 - 3335.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. W. Park, M. N. Younes, S. A. Jasser, O. G. Yigitbasi, G. Zhou, C. D. Bucana, B. N. Bekele, and J. N. Myers
AEE788, a Dual Tyrosine Kinase Receptor Inhibitor, Induces Endothelial Cell Apoptosis in Human Cutaneous Squamous Cell Carcinoma Xenografts in Nude Mice
Clin. Cancer Res., March 1, 2005; 11(5): 1963 - 1973.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W. Zhang, D. J. Park, B. Lu, D. Y. Yang, M. Gordon, S. Groshen, J. Yun, O. A. Press, D. Vallbohmer, K. Rhodes, et al.
Epidermal Growth Factor Receptor Gene Polymorphisms Predict Pelvic Recurrence in Patients with Rectal Cancer Treated with Chemoradiation
Clin. Cancer Res., January 15, 2005; 11(2): 600 - 605.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
P. M. Harari
Promising new advances in head and neck radiotherapy
Ann. Onc., January 1, 2005; 16(suppl_6): vi13 - vi19.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
J. Bourhis
New approaches to enhance chemotherapy in SCCHN
Ann. Onc., January 1, 2005; 16(suppl_6): vi20 - vi24.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
E. Vokes
Current treatments and promising investigations in a multidisciplinary setting
Ann. Onc., January 1, 2005; 16(suppl_6): vi25 - vi30.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
K. K. Ang
Concurrent Radiation Chemotherapy for Locally Advanced Head and Neck Carcinoma: Are We Addressing Burning Subjects?
J. Clin. Oncol., December 1, 2004; 22(23): 4657 - 4659.
[Full Text] [PDF]

Home page
 Arch Otolaryngol Head Neck SurgHome page
D. L. Schwartz, J. Rajendran, B. Yueh, M. D. Coltrera, M. LeBlanc, J. Eary, and K. Krohn
FDG-PET Prediction of Head and Neck Squamous Cell Cancer Outcomes
Arch Otolaryngol Head Neck Surg, December 1, 2004; 130(12): 1361 - 1367.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. H. Kalish, R. A. Kwong, I. E. Cole, R. M. Gallagher, R. L. Sutherland, and E. A. Musgrove
Deregulated Cyclin D1 Expression Is Associated with Decreased Efficacy of the Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Gefitinib in Head and Neck Squamous Cell Carcinoma Cell Lines
Clin. Cancer Res., November 15, 2004; 10(22): 7764 - 7774.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
N. R. Schechter, R. E. Wendt III, D. J. Yang, A. Azhdarinia, W. D. Erwin, A. M. Stachowiak, L. D. Broemeling, E. E. Kim, J. D. Cox, D. A. Podoloff, et al.
Radiation Dosimetry of 99mTc-Labeled C225 in Patients with Squamous Cell Carcinoma of the Head and Neck
J. Nucl. Med., October 1, 2004; 45(10): 1683 - 1687.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. L. Dominguez-Escrig, J. D. Kelly, D. E. Neal, S. M. King, and B. R. Davies
Evaluation of the Therapeutic Potential of the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Gefitinib in Preclinical Models of Bladder Cancer
Clin. Cancer Res., July 15, 2004; 10(14): 4874 - 4884.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. E.W. Cohen, M. W. Lingen, and E. E. Vokes
The Expanding Role of Systemic Therapy in Head and Neck Cancer
J. Clin. Oncol., May 1, 2004; 22(9): 1743 - 1752.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Ke, X. Wen, M. Gurfinkel, C. Charnsangavej, S. Wallace, E. M. Sevick-Muraca, and C. Li
Near-Infrared Optical Imaging of Epidermal Growth Factor Receptor in Breast Cancer Xenografts
Cancer Res., November 15, 2003; 63(22): 7870 - 7875.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Q.-T. Le and A. J. Giaccia
Therapeutic Exploitation of the Physiological and Molecular Genetic Alterations in Head and Neck Cancer
Clin. Cancer Res., October 1, 2003; 9(12): 4287 - 4295.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.