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[Cancer Research 62, 652-655, February 1, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

Green Tea Polyphenol Epigallocatechin-3 Gallate Inhibits Her-2/Neu Signaling, Proliferation, and Transformed Phenotype of Breast Cancer Cells1

Stefania Pianetti2, Shangqin Guo2, Kathryn T. Kavanagh and Gail E. Sonenshein3

Departments of Biochemistry [S. P., S. G., G. E. S.], and Pathology and Laboratory Medicine [K. T. K.], and Program in Research on Women’s Health [S. P., S. G., K. T. K., G. E. S.], Boston University School of Medicine, Boston, Massachusetts 02118-2394

Overexpression of the epidermal growth factor receptor family member Her-2/neu in breast cancer is associated with poor prognosis. With evidence accumulating for a chemopreventive role of green tea polyphenols, the effects of epigallocatechin-3 gallate (EGCG) on Her-2/neu-overexpressing breast cancer cells were examined. EGCG inhibited mouse mammary tumor virus (MMTV)-Her-2/neu NF639 cell growth in culture and soft agar. EGCG reduced signaling via the phosphatidylinositol 3- kinase, Akt kinase to NF-{kappa}B pathway because of inhibition of basal Her-2/neu receptor tyrosine phosphorylation. EGCG similarly inhibited basal receptor phosphorylation in SMF and Ba/F3 2 + 4 cells, which suggests the potential beneficial use of EGCG in adjuvant therapy of tumors with Her-2/neu overexpression.




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