Cancer Research Cancer Epigenetics EMT and Cancer Progression and Treatment
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ryu, B.
Right arrow Articles by Kern, S. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ryu, B.
Right arrow Articles by Kern, S. E.
[Cancer Research 62, 819-826, February 1, 2002]
© 2002 American Association for Cancer Research

Molecular Biology and Genetics

Relationships and Differentially Expressed Genes among Pancreatic Cancers Examined by Large-scale Serial Analysis of Gene Expression1

Byungwoo Ryu, Jessa Jones, Natalie J. Blades, Giovanni Parmigiani, Michael A. Hollingsworth, Ralph H. Hruban and Scott E. Kern2

Departments of Oncology [B. R., J. J., G. P., R. H. H., S. E. K.], Biostatistics [N. J. B., G. P.], and Pathology [R. H. H., G. P., S. E. K.], The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, and The Eppley Institute, The University of Nebraska Medical Center, Omaha, Nebraska 68198 [M. A. H.]

Pancreatic adenocarcinoma is among the most fatal of cancers, in part because of late diagnosis and a lack of effective therapies. Comprehensive studies are needed to better understand and address the cellular mechanisms and pathways of tumorigenesis. Serial analysis of gene expression was used to analyze gene expression profiles of pancreatic cancer cell lines, short-term cultures of normal pancreatic ductal epithelium, and primary pancreatic cancer tissue. A total of 294,920 tags representing 77,746 genes in 10 serial analysis of gene expression libraries were analyzed. A pancreatic cancer cell line (Hs766T) that exhibited a "normoid" profile of gene expression was identified. Several genes that may be involved in the fundamental nature of malignant changes in pancreatic ductal epithelium were suggested from those differentially and highly expressed in pancreatic cancer cells as compared with normal epithelium. Some overexpressed genes, such as S100A4, prostate stem cell antigen, carcinoembryonic antigen-related cell adhesion molecule 6, and mesothelin, suggest potential use as diagnostic markers. Others suggest potential novel therapeutic targets.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
R. J. Kreitman, R. Hassan, D. J. FitzGerald, and I. Pastan
Phase I Trial of Continuous Infusion Anti-Mesothelin Recombinant Immunotoxin SS1P
Clin. Cancer Res., August 15, 2009; 15(16): 5274 - 5279.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. J. Riley, K. P. Engelhardt, J. W. Saldanha, W. Qi, L. S. Cooke, Y. Zhu, S. T. Narayan, K. Shakalya, K. D. Croce, I. G. Georgiev, et al.
Design and Activity of a Murine and Humanized Anti-CEACAM6 Single-Chain Variable Fragment in the Treatment of Pancreatic Cancer
Cancer Res., March 1, 2009; 69(5): 1933 - 1940.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
H. Kurio, E. Murayama, T. Kaneko, Y. Shibata, T. Inai, and H. Iida
Intron Retention Generates a Novel Isoform of CEACAM6 That May Act as an Adhesion Molecule in the Ectoplasmic Specialization Structures Between Spermatids and Sertoli Cells in Rat Testis
Biol Reprod, December 1, 2008; 79(6): 1062 - 1073.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. Ramachandran, T. Arumugam, H. Wang, and C. D. Logsdon
Anterior Gradient 2 Is Expressed and Secreted during the Development of Pancreatic Cancer and Promotes Cancer Cell Survival
Cancer Res., October 1, 2008; 68(19): 7811 - 7818.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
G. Feldmann and A. Maitra
Molecular Genetics of Pancreatic Ductal Adenocarcinomas and Recent Implications for Translational Efforts
J. Mol. Diagn., March 1, 2008; 10(2): 111 - 122.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
M. D. Robinson and G. K. Smyth
Moderated statistical tests for assessing differences in tag abundance
Bioinformatics, November 1, 2007; 23(21): 2881 - 2887.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Hucl, J. R. Brody, E. Gallmeier, C. A. Iacobuzio-Donahue, I. K. Farrance, and S. E. Kern
High Cancer-Specific Expression of Mesothelin (MSLN) Is Attributable to an Upstream Enhancer Containing a Transcription Enhancer Factor Dependent MCAT Motif
Cancer Res., October 1, 2007; 67(19): 9055 - 9065.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. Ortiz-Zapater, S. Peiro, O. Roda, J. M. Corominas, S. Aguilar, C. Ampurdanes, F. X. Real, and P. Navarro
Tissue Plasminogen Activator Induces Pancreatic Cancer Cell Proliferation by a Non-Catalytic Mechanism That Requires Extracellular Signal-Regulated Kinase 1/2 Activation through Epidermal Growth Factor Receptor and Annexin A2
Am. J. Pathol., May 1, 2007; 170(5): 1573 - 1584.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. Jimeno and M. Hidalgo
Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer.
Mol. Cancer Ther., April 1, 2006; 5(4): 787 - 796.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. C. Cunningham, F. Kamangar, M. P. Kim, S. Hammoud, R. Haque, C. A. Iacobuzio-Donahue, A. Maitra, R. Ashfaq, S. Hustinx, R. E. Heitmiller, et al.
Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions.
Cancer Epidemiol. Biomarkers Prev., February 1, 2006; 15(2): 281 - 287.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
R. Chen, S. Pan, T. A. Brentnall, and R. Aebersold
Proteomic Profiling of Pancreatic Cancer for Biomarker Discovery
Mol. Cell. Proteomics, April 1, 2005; 4(4): 523 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
C. P. Landowski, B. S. Vig, X. Song, and G. L. Amidon
Targeted delivery to PEPT1-overexpressing cells: Acidic, basic, and secondary floxuridine amino acid ester prodrugs
Mol. Cancer Ther., April 1, 2005; 4(4): 659 - 667.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. B. Prasad, A. V. Biankin, N. Fukushima, A. Maitra, S. Dhara, A. G. Elkahloun, R. H. Hruban, M. Goggins, and S. D. Leach
Gene Expression Profiles in Pancreatic Intraepithelial Neoplasia Reflect the Effects of Hedgehog Signaling on Pancreatic Ductal Epithelial Cells
Cancer Res., March 1, 2005; 65(5): 1619 - 1626.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. Aguilar, J. M. Corominas, N. Malats, J. A. Pereira, M. Dufresne, F. X. Real, and P. Navarro
Tissue Plasminogen Activator in Murine Exocrine Pancreas Cancer: Selective Expression in Ductal Tumors and Contribution to Cancer Progression
Am. J. Pathol., October 1, 2004; 165(4): 1129 - 1139.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. M. Thomas, L. M. Santarsiero, E. R. Lutz, T. D. Armstrong, Y.-C. Chen, L.-Q. Huang, D. A. Laheru, M. Goggins, R. H. Hruban, and E. M. Jaffee
Mesothelin-specific CD8+ T Cell Responses Provide Evidence of In Vivo Cross-Priming by Antigen-Presenting Cells in Vaccinated Pancreatic Cancer Patients
J. Exp. Med., August 2, 2004; 200(3): 297 - 306.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. L. Kominsky, M. Vali, D. Korz, T. G. Gabig, S. A. Weitzman, P. Argani, and S. Sukumar
Clostridium perfringens Enterotoxin Elicits Rapid and Specific Cytolysis of Breast Carcinoma Cells Mediated through Tight Junction Proteins Claudin 3 and 4
Am. J. Pathol., May 1, 2004; 164(5): 1627 - 1633.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Koopmann, P. Buckhaults, D. A. Brown, M. L. Zahurak, N. Sato, N. Fukushima, L. J. Sokoll, D. W. Chan, C. J. Yeo, R. H. Hruban, et al.
Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers
Clin. Cancer Res., April 1, 2004; 10(7): 2386 - 2392.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J. Koopmann, N. S. Fedarko, A. Jain, A. Maitra, C. Iacobuzio-Donahue, A. Rahman, R. H. Hruban, C. J. Yeo, and M. Goggins
Evaluation of Osteopontin as Biomarker for Pancreatic Adenocarcinoma
Cancer Epidemiol. Biomarkers Prev., March 1, 2004; 13(3): 487 - 491.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
N. Sato, N. Fukushima, A. Maitra, C. A. Iacobuzio-Donahue, N. T. van Heek, J. L. Cameron, C. J. Yeo, R. H. Hruban, and M. Goggins
Gene Expression Profiling Identifies Genes Associated with Invasive Intraductal Papillary Mucinous Neoplasms of the Pancreas
Am. J. Pathol., March 1, 2004; 164(3): 903 - 914.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Koopmann, Z. Zhang, N. White, J. Rosenzweig, N. Fedarko, S. Jagannath, M. I. Canto, C. J. Yeo, D. W. Chan, and M. Goggins
Serum Diagnosis of Pancreatic Adenocarcinoma Using Surface-Enhanced Laser Desorption and Ionization Mass Spectrometry
Clin. Cancer Res., February 1, 2004; 10(3): 860 - 868.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. A. Iacobuzio-Donahue, R. Ashfaq, A. Maitra, N. V. Adsay, G. L. Shen-Ong, K. Berg, M. A. Hollingsworth, J. L. Cameron, C. J. Yeo, S. E. Kern, et al.
Highly Expressed Genes in Pancreatic Ductal Adenocarcinomas: A Comprehensive Characterization and Comparison of the Transcription Profiles Obtained from Three Major Technologies
Cancer Res., December 15, 2003; 63(24): 8614 - 8622.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Sato, A. Maitra, N. Fukushima, N. T. van Heek, H. Matsubayashi, C. A. Iacobuzio-Donahue, C. Rosty, and M. Goggins
Frequent Hypomethylation of Multiple Genes Overexpressed in Pancreatic Ductal Adenocarcinoma
Cancer Res., July 15, 2003; 63(14): 4158 - 4166.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. D. Logsdon, D. M. Simeone, C. Binkley, T. Arumugam, J. K. Greenson, T. J. Giordano, D. E. Misek, and S. Hanash
Molecular Profiling of Pancreatic Adenocarcinoma and Chronic Pancreatitis Identifies Multiple Genes Differentially Regulated in Pancreatic Cancer
Cancer Res., May 15, 2003; 63(10): 2649 - 2657.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C. A. Iacobuzio-Donahue, A. Maitra, M. Olsen, A. W. Lowe, N. T. Van Heek, C. Rosty, K. Walter, N. Sato, A. Parker, R. Ashfaq, et al.
Exploration of Global Gene Expression Patterns in Pancreatic Adenocarcinoma Using cDNA Microarrays
Am. J. Pathol., April 1, 2003; 162(4): 1151 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C. A. Iacobuzio-Donahue, A. Maitra, G. L. Shen-Ong, T. van Heek, R. Ashfaq, R. Meyer, K. Walter, K. Berg, M. A. Hollingsworth, J. L. Cameron, et al.
Discovery of Novel Tumor Markers of Pancreatic Cancer using Global Gene Expression Technology
Am. J. Pathol., April 1, 2002; 160(4): 1239 - 1249.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.