Cancer Research Meeting Calendar Genetics and Biology of Brain Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dan, S.
Right arrow Articles by Yamori, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dan, S.
Right arrow Articles by Yamori, T.
[Cancer Research 62, 1139-1147, February 15, 2002]
© 2002 American Association for Cancer Research

Molecular Biology and Genetics

An Integrated Database of Chemosensitivity to 55 Anticancer Drugs and Gene Expression Profiles of 39 Human Cancer Cell Lines1

Shingo Dan, Tatsuhiko Tsunoda, Osamu Kitahara, Rempei Yanagawa, Hitoshi Zembutsu, Toyomasa Katagiri, Kanami Yamazaki, Yusuke Nakamura and Takao Yamori2

Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Toshima-ku, Tokyo 170-8455 [S. D., K. Y., T. Y.]; Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639 [O. K., R. Y., H. Z., T. K., Y. N.]; and SNP Research Center, RIKEN (Institute of Physical and Chemical Research), Minato-ku, Tokyo 108-8639 [T. T.], Japan

To explore genes that determine the sensitivity of cancer cells to anticancer drugs, we investigated using cDNA microarrays the expression of 9216 genes in 39 human cancer cell lines pharmacologically characterized on treatment with various anticancer drugs. A bioinformatical approach was then exploited to identify genes related to anticancer drug sensitivity. An integrated database of gene expression and drug sensitivity profiles was constructed and used to identify genes with expression patterns that showed significant correlation to patterns of drug responsiveness. As a result, sets of genes were extracted for each of the 55 anticancer drugs examined. Whereas some genes commonly correlated with various classes of anticancer drugs, other genes correlated only with specific drugs with similar mechanisms of action. This latter group of genes may reflect the efficacy of each class of drugs. Therefore, the integrated database approach of gene expression and chemosensitivity profiles may be useful in the development of systems to predict drug efficacies of cancer cells by examining the expression levels of particular genes.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
J. Lynch, Y. Fukuda, P. Krishnamurthy, G. Du, and J. D. Schuetz
Cell Survival under Stress Is Enhanced by a Mitochondrial ATP-Binding Cassette Transporter That Regulates Hemoproteins
Cancer Res., July 1, 2009; 69(13): 5560 - 5567.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Shichiri, N. Fukai, Y. Kono, and Y. Tanaka
Rifampicin as an Oral Angiogenesis Inhibitor Targeting Hepatic Cancers
Cancer Res., June 1, 2009; 69(11): 4760 - 4768.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Takahata, Y. Inoue, H. Tsuda, I. Imoto, D. Koinuma, M. Hayashi, T. Ichikura, T. Yamori, K. Nagasaki, M. Yoshida, et al.
SKI and MEL1 Cooperate to Inhibit Transforming Growth Factor-{beta} Signal in Gastric Cancer Cells
J. Biol. Chem., January 30, 2009; 284(5): 3334 - 3344.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
N. Nakatsu, T. Nakamura, K. Yamazaki, S. Sadahiro, H. Makuuchi, J. Kanno, and T. Yamori
Evaluation of Action Mechanisms of Toxic Chemicals Using JFCR39, a Panel of Human Cancer Cell Lines
Mol. Pharmacol., November 1, 2007; 72(5): 1171 - 1180.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. D. Minna, L. Girard, and Y. Xie
Tumor mRNA Expression Profiles Predict Responses to Chemotherapy
J. Clin. Oncol., October 1, 2007; 25(28): 4329 - 4336.
[Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. Jimeno, B. Rubio-Viqueira, M. L. Amador, V. Grunwald, A. Maitra, C. Iacobuzio-Donahue, and M. Hidalgo
Dual mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic cancer
Mol. Cancer Ther., March 1, 2007; 6(3): 1079 - 1088.
[Abstract] [Full Text] [PDF]

Home page
 J Biomol ScreenHome page
M. Fryknas, L. Rickardson, M. Wickstrom, S. Dhar, H. Lovborg, J. Gullbo, P. Nygren, M. G. Gustafsson, A. Isaksson, and R. Larsson
Phenotype-Based Screening of Mechanistically Annotated Compounds in Combination with Gene Expression and Pathway Analysis Identifies Candidate Drug Targets in a Human Squamous Carcinoma Cell Model
J Biomol Screen, August 1, 2006; 11(5): 457 - 468.
[Abstract] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
S.-i. Yaguchi, Y. Fukui, I. Koshimizu, H. Yoshimi, T. Matsuno, H. Gouda, S. Hirono, K. Yamazaki, and T. Yamori
Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.
J Natl Cancer Inst, April 19, 2006; 98(8): 545 - 556.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. D. Petty, K. M. Kerr, G. I. Murray, M. C. Nicolson, P. H. Rooney, D. Bissett, and E. S.R. Collie-Duguid
Tumor Transcriptome Reveals the Predictive and Prognostic Impact of Lysosomal Protease Inhibitors in Non-Small-Cell Lung Cancer
J. Clin. Oncol., April 10, 2006; 24(11): 1729 - 1744.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. Wallqvist, J. Connelly, E. A. Sausville, D. G. Covell, and A. Monks
Differential Gene Expression as a Potential Classifier of 2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole-Sensitive and -Insensitive Cell Lines
Mol. Pharmacol., March 1, 2006; 69(3): 737 - 748.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
N. Nakatsu, Y. Yoshida, K. Yamazaki, T. Nakamura, S. Dan, Y. Fukui, and T. Yamori
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays
Mol. Cancer Ther., March 1, 2005; 4(3): 399 - 412.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
K. Iwao-Koizumi, R. Matoba, N. Ueno, S. J. Kim, A. Ando, Y. Miyoshi, E. Maeda, S. Noguchi, and K. Kato
Prediction of Docetaxel Response in Human Breast Cancer by Gene Expression Profiling
J. Clin. Oncol., January 20, 2005; 23(3): 422 - 431.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. Michael and M.M. Doherty
Tumoral Drug Metabolism: Overview and Its Implications for Cancer Therapy
J. Clin. Oncol., January 1, 2005; 23(1): 205 - 229.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
H.-R. Park, A. Tomida, S. Sato, Y. Tsukumo, J. Yun, T. Yamori, Y. Hayakawa, T. Tsuruo, and K. Shin-ya
Effect on Tumor Cells of Blocking Survival Response to Glucose Deprivation
J Natl Cancer Inst, September 1, 2004; 96(17): 1300 - 1310.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
Y. Wu, P. de Kievit, L. Vahlkamp, D. Pijnenburg, M. Smit, M. Dankers, D. Melchers, M. Stax, P. J. Boender, C. Ingham, et al.
Quantitative assessment of a novel flow-through porous microarray for the rapid analysis of gene expression profiles
Nucleic Acids Res., August 27, 2004; 32(15): e123 - e123.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. D. Petty, M. C. Nicolson, K. M. Kerr, E. Collie-Duguid, and G. I. Murray
Gene Expression Profiling in Non-Small Cell Lung Cancer: From Molecular Mechanisms to Clinical Application
Clin. Cancer Res., May 15, 2004; 10(10): 3237 - 3248.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. R. Bani, M. I. Nicoletti, N. W. Alkharouf, C. Ghilardi, D. Petersen, E. Erba, E. A. Sausville, E. T. Liu, and R. Giavazzi
Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts
Mol. Cancer Ther., February 1, 2004; 3(2): 111 - 121.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Vekris, D. Meynard, M.-C. Haaz, M. Bayssas, J. Bonnet, and J. Robert
Molecular Determinants of the Cytotoxicity of Platinum Compounds: The Contribution of in Silico Research
Cancer Res., January 1, 2004; 64(1): 356 - 362.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. M. Mariadason, D. Arango, Q. Shi, A. J. Wilson, G. A. Corner, C. Nicholas, M. J. Aranes, M. Lesser, E. L. Schwartz, and L. H. Augenlicht
Gene Expression Profiling-Based Prediction of Response of Colon Carcinoma Cells to 5-Fluorouracil and Camptothecin
Cancer Res., December 15, 2003; 63(24): 8791 - 8812.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Sugiyama, S. Dan, Y. Yoshida, F. Akiyama, K. Sugiyama, Y. Hirai, M. Matsuura, S. Miyata, M. Ushijima, K. Hasumi, et al.
A Large-Scale Gene Expression Comparison of Microdissected, Small-Sized Endometrial Cancers with or without Hyperplasia Matched to Same-Patient Normal Tissue
Clin. Cancer Res., November 15, 2003; 9(15): 5589 - 5600.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. E. Lamendola, Z. Duan, R. Z. Yusuf, and M. V. Seiden
Molecular Description of Evolving Paclitaxel Resistance in the SKOV-3 Human Ovarian Carcinoma Cell Line
Cancer Res., May 1, 2003; 63(9): 2200 - 2205.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Ding and C. R. Cantor
A high-throughput gene expression analysis technique using competitive PCR and matrix-assisted laser desorption ionization time-of-flight MS
PNAS, March 18, 2003; 100(6): 3059 - 3064.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.