Cancer Research Cancer Epigenetics Genetics and Biology of Brain Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shureiqi, I.
Right arrow Articles by Lippman, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shureiqi, I.
Right arrow Articles by Lippman, S. M.
[Cancer Research 62, 1178-1183, February 15, 2002]
© 2002 American Association for Cancer Research

Tumor Biology

GATA-6 Transcriptional Regulation of 15-Lipoxygenase-1 during NSAID-induced Apoptosis in Colorectal Cancer Cells1

Imad Shureiqi2, Wei Jiang, Susan M. Fischer, Xiaochun Xu, Dongning Chen, J. Jack Lee, Reuben Lotan and Scott M. Lippman

Departments of Clinical Cancer Prevention [I. S., W. J., X. X., D. C., S. M. L.], Gastrointestinal Medical Oncology [I. S.], Carcinogenesis [S. M. F.], Biostatistics [J. J. L.], and Division of Cancer Prevention [R. L.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

The mechanisms by which nonsteroidal anti-inflammatory drugs (NSAIDs) induce apoptosis in colorectal cancer cells are undergoing intensive investigation. We found previously that NSAIDs induce apoptosis in these cells by restoring 15-lipoxygenase-1 (15-LOX-1) expression. The present study examined the NSAID mechanism for up-regulating 15-LOX-1 in two colorectal cancer cell lines (RKO and DLD-1). We found that NSAID effects on 15-LOX-1 occurred at the level of transcriptional regulation. We then studied NSAID effects on GATA-6, a transcription factor that suppresses 15-LOX-1 expression. Beginning within 4 h, NSAIDs progressively down-regulated GATA-6 expression. Ectopic GATA-6 expression blocked NSAID induction of 15-LOX-1 and apoptosis. NSAIDs down-regulate GATA-6 to transcriptionally up-regulate 15-LOX-1 and induce apoptosis in colorectal cancer cells.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
X. Zuo, J. S. Morris, and I. Shureiqi
Chromatin Modification Requirements for 15-Lipoxygenase-1 Transcriptional Reactivation in Colon Cancer Cells
J. Biol. Chem., November 14, 2008; 283(46): 31341 - 31347.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Oberthuer, L. Kaderali, Y. Kahlert, B. Hero, F. Westermann, F. Berthold, B. Brors, R. Eils, and M. Fischer
Subclassification and Individual Survival Time Prediction from Gene Expression Data of Neuroblastoma Patients by Using CASPAR
Clin. Cancer Res., October 15, 2008; 14(20): 6590 - 6601.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
N. S. Belaguli, M. Zhang, M. Rigi, M. Aftab, and D. H. Berger
Cooperation between GATA4 and TGF-beta signaling regulates intestinal epithelial gene expression
Am J Physiol Gastrointest Liver Physiol, June 1, 2007; 292(6): G1520 - G1533.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
S. Lu and M. C. Archer
Celecoxib Decreases Fatty Acid Synthase Expression via Down-Regulation of c-Jun N-Terminal Kinase-1
Experimental Biology and Medicine, May 1, 2007; 232(5): 643 - 653.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
I. Shureiqi, X. Zuo, R. Broaddus, Y. Wu, B. Guan, J. S. Morris, and S. M. Lippman
The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer
FASEB J, March 1, 2007; 21(3): 743 - 753.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
H. P. Ciolino, C. J. MacDonald, O. S. Memon, S. E. Bass, and G. C. Yeh
Sulindac regulates the aryl hydrocarbon receptor-mediated expression of Phase 1 metabolic enzymes in vivo and in vitro
Carcinogenesis, August 1, 2006; 27(8): 1586 - 1592.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. M. Lippman and J. J. Lee
Reducing the "Risk" of Chemoprevention: Defining and Targeting High Risk--2005 AACR Cancer Research and Prevention Foundation Award Lecture.
Cancer Res., March 15, 2006; 66(6): 2893 - 2903.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I. Shureiqi, Y. Wu, D. Chen, X. L. Yang, B. Guan, J. S. Morris, P. Yang, R. A. Newman, R. Broaddus, S. R. Hamilton, et al.
The Critical Role of 15-Lipoxygenase-1 in Colorectal Epithelial Cell Terminal Differentiation and Tumorigenesis
Cancer Res., December 15, 2005; 65(24): 11486 - 11492.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
L. C. Hsi, X. Xi, Y. Wu, and S. M. Lippman
The methyltransferase inhibitor 5-aza-2-deoxycytidine induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells
Mol. Cancer Ther., November 1, 2005; 4(11): 1740 - 1746.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Deguchi, S. W. Xing, I. Shureiqi, P. Yang, R. A. Newman, S. M. Lippman, S. J. Feinmark, B. Oehlen, and I. B. Weinstein
Activation of Protein Kinase G Up-regulates Expression of 15-Lipoxygenase-1 in Human Colon Cancer Cells
Cancer Res., September 15, 2005; 65(18): 8442 - 8447.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Oskouian, J. Mendel, E. Shocron, M. A. Lee Jr., H. Fyrst, and J. D. Saba
Regulation of Sphingosine-1-phosphate Lyase Gene Expression by Members of the GATA Family of Transcription Factors
J. Biol. Chem., May 6, 2005; 280(18): 18403 - 18410.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. C. Hsi, X. Xi, R. Lotan, I. Shureiqi, and S. M. Lippman
The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Induces Apoptosis via Induction of 15-Lipoxygenase-1 in Colorectal Cancer Cells
Cancer Res., December 1, 2004; 64(23): 8778 - 8781.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. Shureiqi, W. Jiang, X. Zuo, Y. Wu, J. B. Stimmel, L. M. Leesnitzer, J. S. Morris, H.-Z. Fan, S. M. Fischer, and S. M. Lippman
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-{delta} to induce apoptosis in colorectal cancer cells
PNAS, August 19, 2003; 100(17): 9968 - 9973.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
I. Ketola, J. Toppari, T. Vaskivuo, R. Herva, J. S. Tapanainen, and M. Heikinheimo
Transcription Factor GATA-6, Cell Proliferation, Apoptosis, and Apoptosis-Related Proteins Bcl-2 and Bax in Human Fetal Testis
J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1858 - 1865.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Y. Kim, A.-G. Ma, K. Kitta, S. N. Fitch, T. Ikeda, Y. Ihara, A. R. Simon, T. Evans, and Y. J. Suzuki
Anthracycline-Induced Suppression of GATA-4 Transcription Factor: Implication in the Regulation of Cardiac Myocyte Apoptosis
Mol. Pharmacol., February 1, 2003; 63(2): 368 - 377.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. M. Lippman and W. K. Hong
Cancer Prevention Science and Practice
Cancer Res., September 15, 2002; 62(18): 5119 - 5125.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.