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[Cancer Research 62, 1184-1190, February 15, 2002]
© 2002 American Association for Cancer Research

Tumor Biology

Molecular Classification of Head and Neck Squamous Cell Carcinoma Using cDNA Microarrays1

Thomas J. Belbin, Bhuvanesh Singh, Ilana Barber, Nicholas Socci, Bruce Wenig, Richard Smith, Michael B. Prystowsky and Geoffrey Childs2

Departments of Molecular Genetics [T. J. B., G. C.] and Pathology, Montefiore Medical Center [T. J. B., I. B., B. W., M. B. P.], Albert Einstein College of Medicine, Bronx, New York 10461; Department of Otolaryngology, Montefiore Medical Center, Bronx, New York 10467 [R. S.]; Laboratory of Epithelial Cancer Biology, Head and Neck Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 [B. S.]; and Center for Studies in Physics and Biology, The Rockefeller University, New York, New York 10021 [N. S.]

Squamous cell carcinomas of the head and neck constitute an anatomically heterogeneous group of neoplasms that share in common a causal association with tobacco and alcohol exposure. The clinical course of these neoplasms is difficult to predict based on established prognostic clinicopathological criteria. Given the genetic complexity of head and neck cancers, it is not surprising that correlations with individual genetic abnormalities have also been disappointing. Several authors have suggested that global gene expression patterns can be used to subgroup patients with cancer. Here we report the use of cDNA microarrays containing 9216 clones to measure global patterns of gene expression in these neoplasms. We have used a statistical algorithm to identify 375 genes, which divide patients with head and neck tumors into two clinically distinct subgroups based on gene expression patterns. Our results demonstrate that gene expression profiling can be used as a predictor of outcome.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
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Copyright © 2002 by the American Association for Cancer Research.