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Array-based Comparative Genomic Hybridization for the Differential Diagnosis of Renal Cell Cancer¹

Cancer Center and Departments of Laboratory Medicine and Urology, University of California-San Francisco, San Francisco, California 94143-0808 [M. W., J. A. V., A. N. J., D. H. M., F. M. W.]; Department of Urology, Laboratory of Molecular Oncology, Ruprecht-Karls-University of Heidelberg, D69120 Heidelberg, Germany [M. W., G. K.]; Department of Human Genetics, University Medical Center Nijmegen, Nijmegen 6500, the Netherlands [J. A. V.]; Department of Urology, Stanford University School of Medicine, Stanford, California 94305 [J. C. P.]; and Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 [A. B. O.]

Array-based comparative genomic hybridization (CGH) uses multiple genomic clones arrayed on a slide to detect relative copy number of tumor DNA sequences. Application of array CGH to tumor specimens makes genetic diagnosis of cancers possible and may help to differentiate relevant subsets of tumors, biologically and clinically, which would allow better prognostic and therapeutic decision making. In this study, we have used array-based CGH to detect DNA copy number alterations in distinct types of renal cell carcinomas for diagnostic purposes. We were able to correctly diagnose 33 of 34 malignant tumors by automated computational means and to group together eight benign neoplasms and normal kidney samples. These results indicate that array-based CGH is capable of diagnosing the vast majority of renal cell carcinomas based on their genetic profiles.

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