| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Advances in Brief |
Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, 20133 Milan, Italy [E. A., B. S., M. M., C. G., F. C., E. T., S. M.], and Department of Structural and Functional Biology, University of Insubria, 21100 Varese, Italy [L. P.]
The 67-kDa laminin receptor (67LR) is a high-affinity laminin-binding protein that is overexpressed on the tumor cell surface in a variety of cancers. We report here that the 67LR molecule also functions in the proteolytic cleavage of laminin-1, a relevant event in basement membrane degradation and tumor dissemination. In the presence of a synthetic peptide (peptide G) corresponding to the 67LR laminin binding site, the rate of laminin-1 degradation by the cysteine proteinase cathepsin B was significantly increased, and a new proteolytic fragment particularly active in in vitro cell migration assays was generated. The YIGSR peptide, corresponding to the 67LR binding site on laminin-1, blocked the peptide G-dependent proteolytic degradation. Our results shed light on the mechanism by which an adhesion receptor such as the 67LR plays a major role in tumor aggressiveness and metastasis.
This article has been cited by other articles:
|
|
 |
|
  H.-J. Nam, M. D. Lane, E. Padron, B. Gurda, R. McKenna, E. Kohlbrenner, G. Aslanidi, B. Byrne, N. Muzyczka, S. Zolotukhin, et al. Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy Vector J. Virol., November 15, 2007; 81(22): 12260 - 12271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Akache, D. Grimm, K. Pandey, S. R. Yant, H. Xu, and M. A. Kay The 37/67-Kilodalton Laminin Receptor Is a Receptor for Adeno-Associated Virus Serotypes 8, 2, 3, and 9 J. Virol., October 1, 2006; 80(19): 9831 - 9836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Selleri, P. Ragno, P. Ricci, V. Visconte, N. Scarpato, M. V. Carriero, B. Rotoli, G. Rossi, and N. Montuori The metastasis-associated 67-kDa laminin receptor is involved in G-CSF-induced hematopoietic stem cell mobilization Blood, October 1, 2006; 108(7): 2476 - 2484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Wang, W. Zhang, Z. Pei, M. Block, B. Wilson, J. M. Reece, D. S. Miller, and J.-S. Hong Reactive microgliosis participates in MPP+-induced dopaminergic neurodegeneration: role of 67 kDa laminin receptor FASEB J, May 1, 2006; 20(7): 906 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Rohrer, A. L. Barsoum, and J. H. Coggin Jr. Identification of Oncofetal Antigen/Immature Laminin Receptor Protein Epitopes That Activate BALB/c Mouse OFA/iLRP-Specific Effector and Regulatory T Cell Clones. J. Immunol., March 1, 2006; 176(5): 2844 - 2856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V Berno, D Porrini, F Castiglioni, M Campiglio, P Casalini, S M Pupa, A Balsari, S Menard, and E Tagliabue The 67 kDa laminin receptor increases tumor aggressiveness by remodeling laminin-1 Endocr. Relat. Cancer, June 1, 2005; 12(2): 393 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. Diggle, S. Cruickshank, J. D. Olsburgh, S. Pellegrin, B. Smith, R. E. Banks, P. J. Selby, M. A. Knowles, J. Southgate, and P. Harnden Identification of Genes Up-Regulated in Urothelial Tumors: The 67-kd Laminin Receptor and Tumor-Associated Trypsin Inhibitor Am. J. Pathol., August 1, 2003; 163(2): 493 - 504. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
