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[Cancer Research 62, 1613-1618, March 15, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

The SLUG Zinc-Finger Protein Represses E-Cadherin in Breast Cancer1

Karen M. Hajra, David Y-S. Chen and Eric R. Fearon2

Program in Cellular and Molecular Biology [K. M. H., E. R. F.], Department of Molecular, Cellular, and Developmental Biology [D. Y-S. C.], Comprehensive Cancer Center [E. R. F.], and Departments of Internal Medicine, Human Genetics, and Pathology [E. R. F.], University of Michigan Medical School, Ann Arbor, Michigan 48109

Loss of expression of the E-cadherin cell-cell adhesion molecule is important in carcinoma development and progression. Because previous data suggest that loss of E-cadherin expression in breast carcinoma may result from a dominant transcriptional repression pathway acting on the E-cadherin proximal promoter, we pursued studies of cis sequences and transcription factors regulating E-cadherin expression in breast cancer cells. E-box elements in the E-cadherin promoter were found to play a critical negative regulatory role in E-cadherin gene transcription in breast cancer cell lines lacking E-cadherin transcription. The E-box elements had a minimal role in E-cadherin transcription in breast cancer cell lines expressing E-cadherin. Two zinc-finger transcription factors known to bind E-box elements, SLUG and SNAIL, repressed E-cadherin-driven reporter gene constructs containing wild-type promoter sequences but not those with mutations in the E-box elements. Additionally, both SLUG and SNAIL repressed endogenous E-cadherin expression. These findings suggest SLUG and SNAIL are potential repressors of E-cadherin transcription in carcinomas lacking E-cadherin expression. Analysis of the expression patterns of SLUG, SNAIL, and E-cadherin in breast cancer cell lines demonstrated that expression of SLUG was strongly correlated with loss of E-cadherin transcripts. Taken together, the data indicate the E-box elements in the proximal E-cadherin promoter are critical in transcriptional repression of the E-cadherin gene, and SLUG is a likely in vivo repressor of E-cadherin in breast cancer.




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J. Biol. Chem., October 27, 2006; 281(43): 32469 - 32484.
[Abstract] [Full Text] [PDF]

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Cancer Res., October 1, 2006; 66(19): 9543 - 9556.
[Abstract] [Full Text] [PDF]

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J. Biol. Chem., September 15, 2006; 281(37): 26943 - 26950.
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Home page
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Snail and Slug Play Distinct Roles during Breast Carcinoma Progression.
Clin. Cancer Res., September 15, 2006; 12(18): 5395 - 5402.
[Abstract] [Full Text] [PDF]

Home page
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F. E. Turner, S. Broad, F. L. Khanim, A. Jeanes, S. Talma, S. Hughes, C. Tselepis, and N. A. Hotchin
Slug Regulates Integrin Expression and Cell Proliferation in Human Epidermal Keratinocytes
J. Biol. Chem., July 28, 2006; 281(30): 21321 - 21331.
[Abstract] [Full Text] [PDF]

Home page
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T. Saito, M. Nagai, and M. Ladanyi
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[Abstract] [Full Text] [PDF]

Home page
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T. Toyama, Z. Zhang, H. Iwase, H. Yamashita, Y. Ando, M. Hamaguchi, M. Mizutani, N. Kondo, T. Fujita, Y. Fujii, et al.
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[Abstract] [Full Text] [PDF]

Home page
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M. A. Battle, G. Konopka, F. Parviz, A. L. Gaggl, C. Yang, F. M. Sladek, and S. A. Duncan
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PNAS, May 30, 2006; 103(22): 8419 - 8424.
[Abstract] [Full Text] [PDF]

Home page
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J. Yang, S. A. Mani, and R. A. Weinberg
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Cancer Res., May 1, 2006; 66(9): 4549 - 4552.
[Abstract] [Full Text] [PDF]

Home page
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M. D. Onken, J. P. Ehlers, L. A. Worley, J. Makita, Y. Yokota, and J. W. Harbour
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Cancer Res., May 1, 2006; 66(9): 4602 - 4609.
[Abstract] [Full Text] [PDF]

Home page
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B. Krishnamachary, D. Zagzag, H. Nagasawa, K. Rainey, H. Okuyama, J. H. Baek, and G. L. Semenza
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Cancer Res., March 1, 2006; 66(5): 2725 - 2731.
[Abstract] [Full Text] [PDF]

Home page
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H. Yoshida, R. Broaddus, W. Cheng, S. Xie, and H. Naora
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Cancer Res., January 15, 2006; 66(2): 889 - 897.
[Abstract] [Full Text] [PDF]

Home page
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Cancer development induced by graded expression of Snail in mice
Hum. Mol. Genet., November 15, 2005; 14(22): 3449 - 3461.
[Abstract] [Full Text] [PDF]

Home page
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J.-Y. Shih, M.-F. Tsai, T.-H. Chang, Y.-L. Chang, A. Yuan, C.-J. Yu, S.-B. Lin, G.-Y. Liou, M.-L. Lee, J. J.W. Chen, et al.
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Clin. Cancer Res., November 15, 2005; 11(22): 8070 - 8078.
[Abstract] [Full Text] [PDF]

Home page
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Pc2-mediated Sumoylation of Smad-interacting Protein 1 Attenuates Transcriptional Repression of E-cadherin
J. Biol. Chem., October 21, 2005; 280(42): 35477 - 35489.
[Abstract] [Full Text] [PDF]

Home page
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L. Strizzi, C. Bianco, A. Raafat, W. Abdallah, C. Chang, D. Raafat, M. Hirota, S. Hamada, Y. Sun, N. Normanno, et al.
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J. Cell Sci., October 15, 2005; 118(20): 4633 - 4643.
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A. M. Melnick, K. Adelson, and J. D. Licht
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J. Clin. Oncol., June 10, 2005; 23(17): 3957 - 3970.
[Abstract] [Full Text] [PDF]

Home page
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Ann. Surg. Oncol., June 1, 2005; 12(6): 488 - 496.
[Abstract] [Full Text] [PDF]

Home page
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Clin. Cancer Res., June 1, 2005; 11(11): 4083 - 4089.
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Home page
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Zinc finger domain of Snail functions as a nuclear localization signal for importin {beta}-mediated nuclear import pathway
Genes Cells, May 1, 2005; 10(5): 455 - 464.
[Abstract] [Full Text] [PDF]

Home page
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M. K. Tripathi, S. Misra, S. V. Khedkar, N. Hamilton, C. Irvin-Wilson, C. Sharan, L. Sealy, and G. Chaudhuri
Regulation of BRCA2 Gene Expression by the SLUG Repressor Protein in Human Breast Cells
J. Biol. Chem., April 29, 2005; 280(17): 17163 - 17171.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. I. Yook, X.-Y. Li, I. Ota, E. R. Fearon, and S. J. Weiss
Wnt-dependent Regulation of the E-cadherin Repressor Snail
J. Biol. Chem., March 25, 2005; 280(12): 11740 - 11748.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
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J. Cell Sci., March 1, 2005; 118(5): 873 - 887.
[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., November 5, 2004; 279(45): 46706 - 46714.
[Abstract] [Full Text] [PDF]

Home page
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Aberrant Expression of the Transcription Factors Snail and Slug Alters the Response to Genotoxic Stress
Mol. Cell. Biol., September 1, 2004; 24(17): 7559 - 7566.
[Abstract] [Full Text] [PDF]

Home page
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Cancer Res., August 1, 2004; 64(15): 5154 - 5161.
[Abstract] [Full Text] [PDF]

Home page
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J. Histochem. Cytochem., July 1, 2004; 52(7): 959 - 965.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
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J. Cell Sci., June 1, 2004; 117(13): 2827 - 2839.
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Home page
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Home page
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Home page
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Home page
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Home page
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M. Kremer, L. Quintanilla-Martinez, M. Fuchs, A. Gamboa-Dominguez, S. Haye, H. Kalthoff, E. Rosivatz, C. Hermannstadter, R. Busch, H. Hofler, et al.
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Carcinogenesis, December 1, 2003; 24(12): 1879 - 1886.
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Home page
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