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Carcinogenesis |
National Cancer Center Research Institute, Section for Studies on Metastasis [H. Y., T. O., K. H., Hid. Sas., M. T.], Chemotherapy Division [H. T-B.], and Genetics Division [Hir. Sas., Hir. Sak., T. Y., M. T.], Tokyo 104-0045; Department of Pathology, Nagoya City University Medical School, Nagoya 467-8601 [F. T.]; and Laboratory of Molecular Genetics, Institute of Medical Science, University of Tokyo, Tokyo 108-8639 [I. S.], Japan
Cyclin D1 is a critical gene involved in the regulation of progression throughthe G1 phase of the cell cycle, thereby contributing to cell proliferation. Gene amplification and abnormal expression of Cyclin D1 have been described in several human cancers. To understand their biological significance in skin carcinogenesis, we established Cyclin D1-conditional transgenic mice with C57BL/6J background, in which skin-specific overexpression of Cyclin D1 transgene was observed. The mice were subjected to dimethylbenz[a]anthracene complete skin carcinogenesis studies. After 40 weeks of repeated administration of dimethylbenz[a]anthracene on the skin (once a week), all of the mice with high Cyclin D1 expression had papillomas, whereas only 9.5% of the control mice without the transgene developed papillomas. Primary cultured keratinocytes with induced Cyclin D1 transgene expression showed resistance to calcium-induced terminal differentiation and continued to replicate in vitro. These results clearly provide us with direct experimental evidence that overexpression of CyclinD1 induces excessive dermal cell proliferation via the altered differentiation state of keratinocytes. The conditional transgenic mice described here provide excellent in vivo and in vitro model systems to understand the role of cyclin D1 and deregulation of the cell cycle in carcinogenesis.
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