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Significant Increase of Colonic Mutated Crypts in Ulcerative Colitis Correlatively with Duration of Illness¹

Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228-8555 [I. O., K. H., T. Y., T. M.]; Cellular & Molecular Toxicology Division, Biological Safety Research Center, NIH Sciences, Setagayaku, Tokyo 158-8501 [J. K.]; and Department of Clinical Pathology, Japanese Red Cross Medical Center, Shibuyaku, Tokyo 150-8935 [M. F.], Japan

Mild periodic acid-Schiff (mPAS) staining can discriminate non-O-acetylated(mPAS positive) from O-acetylated (mPAS negative) epithelial sialoglycoproteins in human colonic mucosa, giving three haplotypes of expression of a single polymorphic autosomal gene (oat). Increase in mPAS-positive crypts in heterozygotes is an indication of mutations, and wholly mPAS-positive (stem cell mutated) crypts and clusters of two or more mPAS-positive crypts in heterozygotes of ulcerative colitis (P < 0.0001) were found to be increased significantly, compared with controls. The observed correlation with ulcerative colitis duration (r = 0.892 and 0.853, respectively) supports a chronic inflammation-carcinoma sequence.

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				K Ishiguro, T Yoshida, H Yagishita, Y Numata, and T Okayasu Epithelial and stromal genetic instability contributes to genesis of colorectal adenomas Gut, May 1, 2006; 55(5): 695 - 702. [Abstract] [Full Text] [PDF]