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[Cancer Research 62, 2253-2257, April 15, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

Associations between hOGG1 Sequence Variants and Prostate Cancer Susceptibility1

Jianfeng Xu, Siqun L. Zheng, Aubrey Turner, Sarah D. Isaacs, Kathy E. Wiley, Gregory A. Hawkins, Bao-li Chang, Eugene R. Bleecker, Patrick C. Walsh, Deborah A. Meyers2 and William B. Isaacs

Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157 [J. X., S. L. Z., A. T., G. A. H., B-l. C., E. R. B., D. A. M.], and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 [S. D. I., K. E. W., P. C. W., W. B. I.]

8-Hydroxyguanine is a mutagenic base lesion produced by reactive oxygenspecies. The hOGG1 gene encodes a DNA glycosylase/AP lyase that can suppress the mutagenic effects of 8-hydroxyguanine by catalyzing its removal from oxidized DNA. A population-based (245 cases and 222 controls) and family-based (159 hereditary prostate cancer families) association study was performed to test the hypothesis that sequence variants of hOGG1 increase susceptibility to prostate cancer. We found that the genotype frequency of two sequence variants (11657A/G and Ser326Cys) was significantly different between cases and controls. The association with 11657A/G is confirmed and strengthened by our family-based association study. These results suggest that sequence variants in this gene are associated with prostate cancer risk, presumably through defective DNA repair function of hOGG1.




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Copyright © 2002 by the American Association for Cancer Research.