This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Xu, J. Articles by Isaacs, W. B. Search for Related Content PubMed PubMed Citation Articles by Xu, J. Articles by Isaacs, W. B.

Associations between hOGG1 Sequence Variants and Prostate Cancer Susceptibility¹

Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157 [J. X., S. L. Z., A. T., G. A. H., B-l. C., E. R. B., D. A. M.], and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 [S. D. I., K. E. W., P. C. W., W. B. I.]

8-Hydroxyguanine is a mutagenic base lesion produced by reactive oxygenspecies. The hOGG1 gene encodes a DNA glycosylase/AP lyase that can suppress the mutagenic effects of 8-hydroxyguanine by catalyzing its removal from oxidized DNA. A population-based (245 cases and 222 controls) and family-based (159 hereditary prostate cancer families) association study was performed to test the hypothesis that sequence variants of hOGG1 increase susceptibility to prostate cancer. We found that the genotype frequency of two sequence variants (11657A/G and Ser326Cys) was significantly different between cases and controls. The association with 11657A/G is confirmed and strengthened by our family-based association study. These results suggest that sequence variants in this gene are associated with prostate cancer risk, presumably through defective DNA repair function of hOGG1.

This article has been cited by other articles:

				H. Li, X. Hao, W. Zhang, Q. Wei, and K. Chen The hOGG1 Ser326Cys Polymorphism and Lung Cancer Risk: A Meta-analysis Cancer Epidemiol. Biomarkers Prev., July 1, 2008; 17(7): 1739 - 1745. [Abstract] [Full Text] [PDF]

				R. R. McWilliams, W. R. Bamlet, J. M. Cunningham, E. L. Goode, M. de Andrade, L. A. Boardman, and G. M. Petersen Polymorphisms in DNA Repair Genes, Smoking, and Pancreatic Adenocarcinoma Risk Cancer Res., June 15, 2008; 68(12): 4928 - 4935. [Abstract] [Full Text] [PDF]

				N. L. Nock, M. S. Cicek, L. Li, X. Liu, B. A. Rybicki, A. Moreira, S. J. Plummer, G. Casey, and J. S. Witte Polymorphisms in estrogen bioactivation, detoxification and oxidative DNA base excision repair genes and prostate cancer risk Carcinogenesis, September 1, 2006; 27(9): 1842 - 1848. [Abstract] [Full Text] [PDF]

				B. A. Sokhansanj and D. M. Wilson III Estimating the effect of human base excision repair protein variants on the repair of oxidative DNA base damage. Cancer Epidemiol. Biomarkers Prev., May 1, 2006; 15(5): 1000 - 1008. [Abstract] [Full Text] [PDF]

				P. Rossner Jr., M. B. Terry, M. D. Gammon, F. F. Zhang, S. L. Teitelbaum, S. M. Eng, S. K. Sagiv, M. M. Gaudet, A. I. Neugut, and R. M. Santella OGG1 Polymorphisms and Breast Cancer Risk. Cancer Epidemiol. Biomarkers Prev., April 1, 2006; 15(4): 811 - 815. [Abstract] [Full Text] [PDF]

				J. W. Hill and M. K. Evans Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase Nucleic Acids Res., March 20, 2006; 34(5): 1620 - 1632. [Abstract] [Full Text] [PDF]

				R. K. Nam, W. W. Zhang, M. A.S. Jewett, J. Trachtenberg, L. H. Klotz, M. Emami, L. Sugar, J. Sweet, A. Toi, and S. A. Narod The Use of Genetic Markers to Determine Risk for Prostate Cancer at Prostate Biopsy Clin. Cancer Res., December 1, 2005; 11(23): 8391 - 8397. [Abstract] [Full Text] [PDF]

				R. J. Hung, J. Hall, P. Brennan, and P. Boffetta Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review Am. J. Epidemiol., November 15, 2005; 162(10): 925 - 942. [Abstract] [Full Text] [PDF]

				X. Ouyang, T. L. DeWeese, W. G. Nelson, and C. Abate-Shen Loss-of-Function of Nkx3.1 Promotes Increased Oxidative Damage in Prostate Carcinogenesis Cancer Res., August 1, 2005; 65(15): 6773 - 6779. [Abstract] [Full Text] [PDF]

				M. Kunisada, K. Sakumi, Y. Tominaga, A. Budiyanto, M. Ueda, M. Ichihashi, Y. Nakabeppu, and C. Nishigori 8-Oxoguanine Formation Induced by Chronic UVB Exposure Makes Ogg1 Knockout Mice Susceptible to Skin Carcinogenesis Cancer Res., July 15, 2005; 65(14): 6006 - 6010. [Abstract] [Full Text] [PDF]

				L. Luna, V. Rolseth, G. A. Hildrestrand, M. Otterlei, F. Dantzer, M. Bjoras, and E. Seeberg Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant Nucleic Acids Res., March 30, 2005; 33(6): 1813 - 1824. [Abstract] [Full Text] [PDF]

				R. Fan, T. S. Kumaravel, F. Jalali, P. Marrano, J. A. Squire, and R. G. Bristow Defective DNA Strand Break Repair after DNA Damage in Prostate Cancer Cells: Implications for Genetic Instability and Prostate Cancer Progression Cancer Res., December 1, 2004; 64(23): 8526 - 8533. [Abstract] [Full Text] [PDF]

				W. G. Nelson Prostate Cancer Prevention J. Nutr., November 1, 2004; 134(11): 3211S - 3212S. [Full Text] [PDF]

				K. L. Lockett, M. C. Hall, J. Xu, S. L. Zheng, M. Berwick, S.-C. Chuang, P. E. Clark, S. D. Cramer, K. Lohman, and J. J. Hu The ADPRT V762A Genetic Variant Contributes to Prostate Cancer Susceptibility and Deficient Enzyme Function Cancer Res., September 1, 2004; 64(17): 6344 - 6348. [Abstract] [Full Text] [PDF]

				A. R. Trzeciak, S. G. Nyaga, P. Jaruga, A. Lohani, M. Dizdaroglu, and M. K. Evans Cellular repair of oxidatively induced DNA base lesions is defective in prostate cancer cell lines, PC-3 and DU-145 Carcinogenesis, August 1, 2004; 25(8): 1359 - 1370. [Abstract] [Full Text] [PDF]

				Z. Zhang, Q. Shi, L.-E Wang, E. M. Sturgis, M. R. Spitz, A. K. El-Naggar, W. K. Hong, and Q. Wei No Association between hOGG1 Ser326Cys Polymorphism and Risk of Squamous Cell Carcinoma of the Head and Neck Cancer Epidemiol. Biomarkers Prev., June 1, 2004; 13(6): 1081 - 1083. [Full Text] [PDF]

				J. Listgarten, S. Damaraju, B. Poulin, L. Cook, J. Dufour, A. Driga, J. Mackey, D. Wishart, R. Greiner, and B. Zanke Predictive Models for Breast Cancer Susceptibility from Multiple Single Nucleotide Polymorphisms Clin. Cancer Res., April 15, 2004; 10(8): 2725 - 2737. [Abstract] [Full Text] [PDF]

				J. J. Hu, M. C. Hall, L. Grossman, M. Hedayati, D. L. McCullough, K. Lohman, and L. D. Case Deficient Nucleotide Excision Repair Capacity Enhances Human Prostate Cancer Risk Cancer Res., February 1, 2004; 64(3): 1197 - 1201. [Abstract] [Full Text] [PDF]

				B. A. Rybicki, D. V. Conti, A. Moreira, M. Cicek, G. Casey, and J. S. Witte DNA Repair Gene XRCC1 and XPD Polymorphisms and Risk of Prostate Cancer Cancer Epidemiol. Biomarkers Prev., January 1, 2004; 13(1): 23 - 29. [Abstract] [Full Text] [PDF]

				T. Arai, V. P. Kelly, K. Komoro, O. Minowa, T. Noda, and S. Nishimura Cell Proliferation in Liver of Mmh/Ogg1-deficient Mice Enhances Mutation Frequency because of the Presence of 8-Hydroxyguanine in DNA Cancer Res., July 15, 2003; 63(14): 4287 - 4292. [Abstract] [Full Text] [PDF]

				A. Yamane, K. Shinmura, N. Sunaga, T. Saitoh, S. Yamaguchi, Y. Shinmura, K. Yoshimura, H. Murakami, Y. Nojima, T. Kohno, et al. Suppressive activities of OGG1 and MYH proteins against G:C to T:A mutations caused by 8-hydroxyguanine but not by benzo[a]pyrene diol epoxide in human cells in vivo Carcinogenesis, June 1, 2003; 24(6): 1031 - 1037. [Abstract] [Full Text] [PDF]

				U. Vogel, B. A. Nexo, A. Olsen, B. Thomsen, N. R. Jacobsen, H. Wallin, K. Overvad, and A. Tjonneland No Association Between OGG1 Ser326Cys Polymorphism and Breast Cancer Risk Cancer Epidemiol. Biomarkers Prev., February 1, 2003; 12(2): 170 - 171. [Full Text] [PDF]

				E. L. Goode, C. M. Ulrich, and J. D. Potter Polymorphisms in DNA Repair Genes and Associations with Cancer Risk Cancer Epidemiol. Biomarkers Prev., December 1, 2002; 11(12): 1513 - 1530. [Abstract] [Full Text] [PDF]