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[Cancer Research 62, 2258-2260, April 15, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

Genetic Alterations of the Tumor Suppressor Gene WWOX in Esophageal Squamous Cell Carcinoma1

Tamotsu Kuroki, Francesco Trapasso, Takeshi Shiraishi, Hansjuerg Alder, Koshi Mimori, Masaki Mori and Carlo M. Croce2

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 [T. K., F. T., T. S., H. A., C. M. C.], and Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu 874-0838, Japan [K. M., M. M.]

The WWOX (WW domain containing oxidoreductase) gene was recentlyidentified as a candidate tumor suppressor gene at 16q23.3-24.1, a chromosome region that spans the common fragile site FRA16D. To evaluate the potential role of the WWOX gene in esophageal squamous cell carcinomas, we examined 36 tumors for genetic alterations of the WWOX gene. Loss of heterozygosity (LOH) at the WWOX locus was observed in 14 (39%) tumors. A tumor-specific missense mutation was found in one tumor, and LOH analysis had shown that the other allele was missing. Furthermore, we detected aberrant WWOX gene transcripts with absence of exons 6–8 in two tumors, and complete absence of transcript in one tumor. These results indicate that alteration and inactivation of the WWOX gene may play a role in esophageal squamous cell carcinogenesis.




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Copyright © 2002 by the American Association for Cancer Research.