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[Cancer Research 62, 2493-2497, May 1, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

Hypoxia-inducible Factors HIF-1{alpha} and HIF-2{alpha} in Head and Neck Cancer

Relationship to Tumor Biology and Treatment Outcome in Surgically Resected Patients

Nigel J. P. Beasley, Russell Leek, Mohammed Alam, Helen Turley, Graham J. Cox, Kevin Gatter, Peter Millard, Sue Fuggle and Adrian L. Harris1

Oxford Centre for Head and Neck Oncology, Radcliffe Infirmary, Oxford OX2 6HE [N. J. P. B., G. J. C.], and ICRF Molecular Oncology Group, Institute of Molecular Medicine [N. J. P. B., R. L., M. A., H. T., A. L. H.], Nuffield Department of Clinical Laboratory Sciences [K. G.], Department of Histopathology [P. M.], and Nuffield Department of Surgery, John Radcliffe Hospital, Oxford OX3 9DU [S. F.], United Kingdom

Hypoxia within head and neck squamous cell carcinoma (HNSCC) predicts a poor response to radiotherapy and poor prognosis. Hypoxia-inducible factor (HIF)-1 and HIF-2 are nuclear transcription factors that regulate the cellular response to hypoxia and are important for solid tumor growth and survival. Overexpression of HIF-1{alpha} and HIF-2{alpha} was demonstrated in three HNSCC cell lines under hypoxia and tumor tissue versus normal tissue (n = 20, HIF-1{alpha}, P = 0.023; HIF-2{alpha}, P = 0.013). On immunostaining, HIF-1{alpha} and HIF-2{alpha} expression were localized to tumor nuclei; HIF-2{alpha} expression was also seen in tumor-associated macrophages. Expression of HIF-1{alpha} in surgically treated patients with HNSCC (n = 79) was associated with improved disease-free survival (P = 0.016) and overall survival (P = 0.027).




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Copyright © 2002 by the American Association for Cancer Research.