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Advances in Brief |
Departments of Tumor Immunology [I. J. M. d. V., D. J. E. B. K., N. M. S., G. J. A., C. G. F.], Medical Oncology [W. J. L., C. J. A. P.], Pathology [J. H. S. D., G. N. P. v. M.], Radiology [S. P. S.], Surgery [T. J. R.], and Nuclear Medicine [O. C. B., W. J. G. O.], University Medical Center Nijmegen, 6500 HB Nijmegen, the Netherlands
Dendritic cells are the professional antigen-presenting cells of the immune system. To induce an effective immune response, these cells should not only express high levels of MHC and costimulatory molecules but also migrate into the lymph nodes to interact with naïve T cells. Here, we demonstrate that in vitro-generated mature, but not immature dendritic cells, efficiently migrate into the T-cell areas of lymph nodes of melanoma patients. This difference is confirmed by in vitro studies, in which immature dendritic cells are strongly adherent, whereas mature dendritic cells remain highly motile. Our present findings demonstrate that the ability of dendritic cells to mount a proper immune response correlates with their ability to migrate both in vitro and in vivo.
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S. F. G. van Helden, M. M. Oud, B. Joosten, N. Peterse, C. G. Figdor, and F. N. van Leeuwen PGE2-mediated podosome loss in dendritic cells is dependent on actomyosin contraction downstream of the RhoA-Rho-kinase axis J. Cell Sci., April 1, 2008; 121(7): 1096 - 1106. [Abstract] [Full Text] [PDF] |
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N. Lapteva, M. R. Seethammagari, B. A. Hanks, J. Jiang, J. M. Levitt, K. M. Slawin, and D. M. Spencer Enhanced Activation of Human Dendritic Cells by Inducible CD40 and Toll-like Receptor-4 Ligation Cancer Res., November 1, 2007; 67(21): 10528 - 10537. [Abstract] [Full Text] [PDF] |
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S. Holtkamp, S. Kreiter, A. Selmi, P. Simon, M. Koslowski, C. Huber, O. Tureci, and U. Sahin Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells Blood, December 15, 2006; 108(13): 4009 - 4017. [Abstract] [Full Text] [PDF] |
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H. Yagi, H. Hashizume, T. Horibe, Y. Yoshinari, M. Hata, A. Ohshima, T. Ito, M. Takigawa, A. Shibaki, H. Shimizu, et al. Induction of therapeutically relevant cytotoxic T lymphocytes in humans by percutaneous Peptide immunization. Cancer Res., October 15, 2006; 66(20): 10136 - 10144. [Abstract] [Full Text] [PDF] |
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S. F. G. van Helden, D. J. E. B. Krooshoop, K. C. M. Broers, R. A. P. Raymakers, C. G. Figdor, and F. N. van Leeuwen A Critical Role for Prostaglandin E2 in Podosome Dissolution and Induction of High-Speed Migration during Dendritic Cell Maturation J. Immunol., August 1, 2006; 177(3): 1567 - 1574. [Abstract] [Full Text] [PDF] |
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M. H.M.G.M. den Brok, R. P.M. Sutmuller, S. Nierkens, E. J. Bennink, L. W.J. Toonen, C. G. Figdor, T. J.M. Ruers, and G. J. Adema Synergy between In situ Cryoablation and TLR9 Stimulation Results in a Highly Effective In vivo Dendritic Cell Vaccine. Cancer Res., July 15, 2006; 66(14): 7285 - 7292. [Abstract] [Full Text] [PDF] |
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R. J.C.L.M. Vuylsteke, B. G. Molenkamp, P. A.M. van Leeuwen, S. Meijer, P. G.J.T.B. Wijnands, J. B.A.G. Haanen, R. J. Scheper, and T. D. de Gruijl Tumor-Specific CD8+ T Cell Reactivity in the Sentinel Lymph Node of GM-CSF-Treated Stage I Melanoma Patients is Associated with High Myeloid Dendritic Cell Content. Clin. Cancer Res., May 1, 2006; 12(9): 2826 - 2833. [Abstract] [Full Text] [PDF] |
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D. Schadendorf, S. Ugurel, B. Schuler-Thurner, F. O. Nestle, A. Enk, E.-B. Brocker, S. Grabbe, W. Rittgen, L. Edler, A. Sucker, et al. Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG Ann. Onc., April 1, 2006; 17(4): 563 - 570. [Abstract] [Full Text] [PDF] |
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D. A. Hokey, A. T. Larregina, G. Erdos, S. C. Watkins, and L. D. Falo Jr. Tumor Cell Loaded Type-1 Polarized Dendritic Cells Induce Th1-Mediated Tumor Immunity Cancer Res., November 1, 2005; 65(21): 10059 - 10067. [Abstract] [Full Text] [PDF] |
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B. Morandi, R. Costa, M. Falco, S. Parolini, A. De Maria, G. Ratto, M. C. Mingari, G. Melioli, A. Moretta, and G. Ferlazzo Distinctive Lack of CD48 Expression in Subsets of Human Dendritic Cells Tunes NK Cell Activation J. Immunol., September 15, 2005; 175(6): 3690 - 3697. [Abstract] [Full Text] [PDF] |
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K. Mahnke, Y. Qian, S. Fondel, J. Brueck, C. Becker, and A. H. Enk Targeting of Antigens to Activated Dendritic Cells In vivo Cures Metastatic Melanoma in Mice Cancer Res., August 1, 2005; 65(15): 7007 - 7012. [Abstract] [Full Text] [PDF] |
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H. Dumortier, G. J. D. van Mierlo, D. Egan, W. van Ewijk, R. E. M. Toes, R. Offringa, and C. J. M. Melief Antigen Presentation by an Immature Myeloid Dendritic Cell Line Does Not Cause CTL Deletion In Vivo, but Generates CD8+ Central Memory-Like T Cells That Can Be Rescued for Full Effector Function J. Immunol., July 15, 2005; 175(2): 855 - 863. [Abstract] [Full Text] [PDF] |
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D. Dieckmann, E. S. Schultz, B. Ring, P. Chames, G. Held, H. R. Hoogenboom, and G. Schuler Optimizing the exogenous antigen loading of monocyte-derived dendritic cells Int. Immunol., May 1, 2005; 17(5): 621 - 635. [Abstract] [Full Text] [PDF] |
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M. Schnurr, Q. Chen, A. Shin, W. Chen, T. Toy, C. Jenderek, S. Green, L. Miloradovic, D. Drane, I. D. Davis, et al. Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery Blood, March 15, 2005; 105(6): 2465 - 2472. [Abstract] [Full Text] [PDF] |
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D. A. Caruso, L. M. Orme, A. M. Neale, F. J. Radcliff, G. M. Amor, W. Maixner, P. Downie, T. E. Hassall, M. L.K. Tang, and D. M. Ashley Results of a phase 1 study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children and young adults with brain cancer Neuro-oncol, July 1, 2004; 6(3): 236 - 246. [Abstract] [PDF] |
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M. H. M. G. M. den Brok, R. P. M. Sutmuller, R. van der Voort, E. J. Bennink, C. G. Figdor, T. J. M. Ruers, and G. J. Adema In Situ Tumor Ablation Creates an Antigen Source for the Generation of Antitumor Immunity Cancer Res., June 1, 2004; 64(11): 4024 - 4029. [Abstract] [Full Text] [PDF] |
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R. H. Vonderheide, S. M. Domchek, J. L. Schultze, D. J. George, K. M. Hoar, D.-Y. Chen, K. F. Stephans, K. Masutomi, M. Loda, Z. Xia, et al. Vaccination of Cancer Patients Against Telomerase Induces Functional Antitumor CD8+ T Lymphocytes Clin. Cancer Res., February 1, 2004; 10(3): 828 - 839. [Abstract] [Full Text] [PDF] |
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K. Brown, W. Gao, S. Alber, A. Trichel, M. Murphey-Corb, S. C. Watkins, A. Gambotto, and S. M. Barratt-Boyes Adenovirus-Transduced Dendritic Cells Injected into Skin or Lymph Node Prime Potent Simian Immunodeficiency Virus-Specific T Cell Immunity in Monkeys J. Immunol., December 15, 2003; 171(12): 6875 - 6882. [Abstract] [Full Text] [PDF] |
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S. Nair, C. McLaughlin, A. Weizer, Z. Su, D. Boczkowski, J. Dannull, J. Vieweg, and E. Gilboa Injection of Immature Dendritic Cells into Adjuvant-Treated Skin Obviates the Need for Ex Vivo Maturation J. Immunol., December 1, 2003; 171(11): 6275 - 6282. [Abstract] [Full Text] [PDF] |
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I. J. M. de Vries, W. J. Lesterhuis, N. M. Scharenborg, L. P. H. Engelen, D. J. Ruiter, M.-J. P. Gerritsen, S. Croockewit, C. M. Britten, R. Torensma, G. J. Adema, et al. Maturation of Dendritic Cells Is a Prerequisite for Inducing Immune Responses in Advanced Melanoma Patients Clin. Cancer Res., November 1, 2003; 9(14): 5091 - 5100. [Abstract] [Full Text] [PDF] |
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