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[Cancer Research 63, 12-17, January 2003]
© 2003 American Association for Cancer Research

Advances in Brief

Effective Migration of Antigen-pulsed Dendritic Cells to Lymph Nodes in Melanoma Patients Is Determined by Their Maturation State1 ,2

I. Jolanda M. de Vries3, Daniëlle J. E. B. Krooshoop3, Nicole M. Scharenborg, W. Joost Lesterhuis, J. Heleen S. Diepstra, Goos N. P. van Muijen, Simon P. Strijk, Theo J. Ruers, Otto C. Boerman, Wim J. G. Oyen, Gosse J. Adema, Cornelis J. A. Punt and Carl G. Figdor4

Departments of Tumor Immunology [I. J. M. d. V., D. J. E. B. K., N. M. S., G. J. A., C. G. F.], Medical Oncology [W. J. L., C. J. A. P.], Pathology [J. H. S. D., G. N. P. v. M.], Radiology [S. P. S.], Surgery [T. J. R.], and Nuclear Medicine [O. C. B., W. J. G. O.], University Medical Center Nijmegen, 6500 HB Nijmegen, the Netherlands

Dendritic cells are the professional antigen-presenting cells of the immune system. To induce an effective immune response, these cells should not only express high levels of MHC and costimulatory molecules but also migrate into the lymph nodes to interact with naïve T cells. Here, we demonstrate that in vitro-generated mature, but not immature dendritic cells, efficiently migrate into the T-cell areas of lymph nodes of melanoma patients. This difference is confirmed by in vitro studies, in which immature dendritic cells are strongly adherent, whereas mature dendritic cells remain highly motile. Our present findings demonstrate that the ability of dendritic cells to mount a proper immune response correlates with their ability to migrate both in vitro and in vivo.




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