| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Advances in Brief |
Laboratories of Human Carcinogenesis [M. S., M. N., R. M. P., M. K-S., K. M., S. O., H. O., C. C. H.] and Cell Biology [Y. H., E. A.], Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, and Biology Division, National Cancer Center Research Institute, Tokyo 104, Japan [J. Y.]
We identified and characterized two new ING family genes, p29ING4 and p28ING5,coding for two proteins of 249 and 240 amino acids, respectively. Both p29ING4 and p28ING5 proteins have a plant homeodomain finger motif also found in other ING proteins, and which is common in proteins involved in chromatin remodeling. p29ING4 or p28ING5 overexpression resulted in a diminished colony-forming efficiency, a decreased cell population in S phase, and the induction of apoptosis in a p53-dependent manner. Both p29ING4 and p28ING5 activate the p21/waf1 promoter, and induce p21/WAF1 expression. p29ING4 and p28ING5 enhance p53 acetylation at Lys-382 residues, and physically interact with p300, a member of histone acetyl transferase complexes, and p53 in vivo. These results indicate that p29ING4 and p28ING5 may be significant modulators of p53 function.
This article has been cited by other articles:
|
|
 |
|
  M. Iizuka, O. F. Sarmento, T. Sekiya, H. Scrable, C. D. Allis, and M. M. Smith Hbo1 Links p53-Dependent Stress Signaling to DNA Replication Licensing Mol. Cell. Biol., January 1, 2008; 28(1): 140 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Colla, S. Tagliaferri, F. Morandi, P. Lunghi, G. Donofrio, D. Martorana, C. Mancini, M. Lazzaretti, L. Mazzera, L. Ravanetti, et al. The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 {alpha} (HIF-1{alpha}) activity: involvement in myeloma-induced angiogenesis Blood, December 15, 2007; 110(13): 4464 - 4475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Ivanov, T. Ivanova, J. Kurash, A. Ivanov, S. Chuikov, F. Gizatullin, E. M. Herrera-Medina, F. Rauscher III, D. Reinberg, and N. A. Barlev Methylation-Acetylation Interplay Activates p53 in Response to DNA Damage Mol. Cell. Biol., October 1, 2007; 27(19): 6756 - 6769. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Unoki, J. C. Shen, Z.-M. Zheng, and C. C. Harris Novel Splice Variants of ING4 and Their Possible Roles in the Regulation of Cell Growth and Motility J. Biol. Chem., November 10, 2006; 281(45): 34677 - 34686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang and G. Li ING3 Promotes UV-induced Apoptosis via Fas/Caspase-8 Pathway in Melanoma Cells J. Biol. Chem., April 28, 2006; 281(17): 11887 - 11893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Kasper, T. Fukuyama, M. A. Biesen, F. Boussouar, C. Tong, A. de Pauw, P. J. Murray, J. M. A. van Deursen, and P. K. Brindle Conditional Knockout Mice Reveal Distinct Functions for the Global Transcriptional Coactivators CBP and p300 in T-Cell Development Mol. Cell. Biol., February 1, 2006; 26(3): 789 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Pedeux, S. Sengupta, J. C. Shen, O. N. Demidov, S. Saito, H. Onogi, K. Kumamoto, S. Wincovitch, S. H. Garfield, M. McMenamin, et al. ING2 Regulates the Onset of Replicative Senescence by Induction of p300-Dependent p53 Acetylation Mol. Cell. Biol., August 1, 2005; 25(15): 6639 - 6648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ozer, L. C. Wu, and R. K. Bruick The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF) PNAS, May 24, 2005; 102(21): 7481 - 7486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. H.Y. He, C. C. Helbing, M. J. Wagner, C. W. Sensen, and K. Riabowol Phylogenetic Analysis of the ING Family of PHD Finger Proteins Mol. Biol. Evol., January 1, 2005; 22(1): 104 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kim, K. Chin, J. W. Gray, and J. M. Bishop A screen for genes that suppress loss of contact inhibition: Identification of ING4 as a candidate tumor suppressor gene in human cancer PNAS, November 16, 2004; 101(46): 16251 - 16256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kataoka, P. Bonnefin, D. Vieyra, X. Feng, Y. Hara, Y. Miura, T. Joh, H. Nakabayashi, H. Vaziri, C. C. Harris, et al. ING1 Represses Transcription by Direct DNA Binding and through Effects on p53 Cancer Res., September 15, 2003; 63(18): 5785 - 5792. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Cell Growth & Differentiation |
