| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Review |
Department of Experimental Oncology, Istituto Nazionale Tumori, Milan 20133, Italy
About 10 years have elapsed since the first whole-genome scanning studies in the mouse to identify loci that affect susceptibility or resistance to tumorigenesis. In that time, >100 cancer modifiers have been mapped, and four strong candidate genes have been identified. Cancer modifier loci affect almost all types of mouse tumorigenesis, with some loci acting on the entire tumorigenic process, whereas others act on specific stages, e.g., tumor initiation or tumor growth/progression. Present evidence indicates that the effects of cancer modifier loci are tissue-specific and restricted to tumor cells. However, a subset of such loci may be involved in different types of tumors, and several chromosomal regions show significant clustering of cancer modifier loci. Human homologues of mouse cancer modifier loci most likely exist and play a role in the risk of sporadic cancer, although present experimental evidence for this possibility is sparse. Mouse cancer modifier loci might serve as the basis for understanding the genetic and biochemical mechanisms of polygenic inheritance of cancer predisposition/resistance. Identification of homologous cancer modifier loci in humans might, in turn, provide a step toward the development of diagnostic, preventive, and therapeutic strategies that target these loci.
This article has been cited by other articles:
|
|
 |
|
  J. Santos, L. Gonzalez-Sanchez, M. Matabuena-deYzaguirre, M. Villa-Morales, P. Cozar, P. Lopez-Nieva, P. Fernandez-Navarro, M. Fresno, M. D. Diaz-Munoz, J.-L. Guenet, et al. A Role for Stroma-Derived Annexin A1 as Mediator in the Control of Genetic Susceptibility to T-Cell Lymphoblastic Malignancies through Prostaglandin E2 Secretion Cancer Res., March 15, 2009; 69(6): 2577 - 2587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Martin, K. J. Carter, S. R. Jean-Philippe, M. Chang, S. Mobashery, S. Thiolloy, C. C. Lynch, L. M. Matrisian, and B. Fingleton Effect of Ablation or Inhibition of Stromal Matrix Metalloproteinase-9 on Lung Metastasis in a Breast Cancer Model Is Dependent on Genetic Background Cancer Res., August 1, 2008; 68(15): 6251 - 6259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. T. Stathopoulos, T. P. Sherrill, D.-S. Cheng, R. M. Scoggins, W. Han, V. V. Polosukhin, L. Connelly, F. E. Yull, B. Fingleton, and T. S. Blackwell Epithelial NF-{kappa}B activation promotes urethane-induced lung carcinogenesis PNAS, November 20, 2007; 104(47): 18514 - 18519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Y. Chang, J. Boulden, J. B. Katz, L. Wang, T. J. Meyer, A. P. Soler, A. J. Muller, and G. C. Prendergast Bin1 Ablation Increases Susceptibility to Cancer during Aging, Particularly Lung Cancer Cancer Res., August 15, 2007; 67(16): 7605 - 7612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sevignani, G. A. Calin, S. C. Nnadi, M. Shimizu, R. V. Davuluri, T. Hyslop, P. Demant, C. M. Croce, and L. D. Siracusa MicroRNA genes are frequently located near mouse cancer susceptibility loci PNAS, May 8, 2007; 104(19): 8017 - 8022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Baran, K. A. Silverman, J. Zeskand, R. Koratkar, A. Palmer, K. McCullen, W. J. Curran Jr, T. B. Edmonston, L. D. Siracusa, and A. M. Buchberg The modifier of Min 2 (Mom2) locus: Embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression Genome Res., May 1, 2007; 17(5): 566 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Y. Chang, J. Boulden, E. Sutanto-Ward, J. B. Duhadaway, A. P. Soler, A. J. Muller, and G. C. Prendergast Bin1 Ablation in Mammary Gland Delays Tissue Remodeling and Drives Cancer Progression Cancer Res., January 1, 2007; 67(1): 100 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Spinola, P. Meyer, S. Kammerer, F. S. Falvella, M. B. Boettger, C. R. Hoyal, C. Pignatiello, R. Fischer, R. B. Roth, U. Pastorino, et al. Association of the PDCD5 Locus With Lung Cancer Risk and Prognosis in Smokers J. Clin. Oncol., April 10, 2006; 24(11): 1672 - 1678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. W. Hunter and N. P. Crawford Germ Line Polymorphism in Metastatic Progression Cancer Res., February 1, 2006; 66(3): 1251 - 1254. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. L. Tarakanova, F. Suarez, S. A. Tibbetts, M. A. Jacoby, K. E. Weck, J. L. Hess, S. H. Speck, and H. W. Virgin IV Murine Gammaherpesvirus 68 Infection Is Associated with Lymphoproliferative Disease and Lymphoma in BALB {beta}2 Microglobulin-Deficient Mice J. Virol., December 1, 2005; 79(23): 14668 - 14679. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Payne and C. J. Kemp Tumor suppressor genetics Carcinogenesis, December 1, 2005; 26(12): 2031 - 2045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wang and M. You Five Loci, SLT1 to SLT5, Controlling the Susceptibility to Spontaneously Occurring Lung Cancer in Mice Cancer Res., September 15, 2005; 65(18): 8158 - 8165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Lesueur, P. D. Pharoah, S. Laing, S. Ahmed, C. Jordan, P. L. Smith, R. Luben, N. J. Wareham, D. F. Easton, A. M. Dunning, et al. Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer Hum. Mol. Genet., August 15, 2005; 14(16): 2349 - 2356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Marx and W. F. Simonds Hereditary Hormone Excess: Genes, Molecular Pathways, and Syndromes Endocr. Rev., August 1, 2005; 26(5): 615 - 661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Bursch, M. Chabicovsky, U. Wastl, B. Grasl-Kraupp, K. Bukowska, H. Taper, and R. Schulte-Hermann Apoptosis in Stages of Mouse Hepatocarcinogenesis: Failure to Counterbalance Cell Proliferation and to Account for Strain Differences in Tumor Susceptibility Toxicol. Sci., May 1, 2005; 85(1): 515 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Bursch, U. Wastl, K. Hufnagl, and R. Schulte-Hermann No Increase of Apoptosis in Regressing Mouse Liver after Withdrawal of Growth Stimuli or Food Restriction Toxicol. Sci., May 1, 2005; 85(1): 507 - 514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Manenti and T. A. Dragani Pas1 haplotype-dependent genetic predisposition to lung tumorigenesis in rodents: a meta-analysis Carcinogenesis, May 1, 2005; 26(5): 875 - 882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pazzaglia, M. Mancuso, M. Tanori, M. J. Atkinson, P. Merola, S. Rebessi, V. Di Majo, V. Covelli, H. Hahn, and A. Saran Modulation of Patched-Associated Susceptibility to Radiation Induced Tumorigenesis by Genetic Background Cancer Res., June 1, 2004; 64(11): 3798 - 3806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, Z. Zhang, Y. Yan, W. J. Lemon, M. LaRegina, C. Morrison, R. Lubet, and M. You A Chemically Induced Model for Squamous Cell Carcinoma of the Lung in Mice: Histopathology and Strain Susceptibility Cancer Res., March 1, 2004; 64(5): 1647 - 1654. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
