This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Asosingh, K. Articles by Vanderkerken, K. Search for Related Content PubMed PubMed Citation Articles by Asosingh, K. Articles by Vanderkerken, K.

Delayed in Vivo Disease Progression Is Associated with High Proportions of CD45⁺ Myeloma Cells in the 5T2MM Murine Model¹

Department of Hematology and Immunology, Vrije Universiteit Brussel-VUB, B-1090 Brussels, Belgium

Both CD45⁺ and CD45^- multiple myeloma (MM) cells are observed in the bone marrow (BM) of MM patients; however, their impact on the outcome of the disease is unknown. Most (92%) of the mice injected with murine 5T2MM cells develop myeloma in 10–12 weeks and show hind leg paralysis at the end phase of the disease. In the end stage 5T2MM cells are predominantly CD45^-, in analogy to the common human situation. Herein we report that 8% of the mice have a delayed tumor progression (14–24 weeks) with a complete different feature in the end stage of the disease. These animals had typically a bowed back and never got paralyzed. The MM cells in the BM of these mice were predominantly CD45⁺.

These data indicate that CD45 subsets are associated with the final outcome of myeloma disease.

This article has been cited by other articles:

				S. Yaccoby The Phenotypic Plasticity of Myeloma Plasma Cells as Expressed by Dedifferentiation into an Immature, Resilient, and Apoptosis-Resistant Phenotype Clin. Cancer Res., November 1, 2005; 11(21): 7599 - 7606. [Abstract] [Full Text] [PDF]

				K. Asosingh, H. De Raeve, E. Menu, I. Van Riet, E. Van Marck, B. Van Camp, and K. Vanderkerken Angiogenic switch during 5T2MM murine myeloma tumorigenesis: role of CD45 heterogeneity Blood, April 15, 2004; 103(8): 3131 - 3137. [Abstract] [Full Text] [PDF]

				W. Matsui, C. A. Huff, Q. Wang, M. T. Malehorn, J. Barber, Y. Tanhehco, B. D. Smith, C. I. Civin, and R. J. Jones Characterization of clonogenic multiple myeloma cells Blood, March 15, 2004; 103(6): 2332 - 2336. [Abstract] [Full Text] [PDF]