This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sohara, Y. Articles by DeClerck, Y. A. Search for Related Content PubMed PubMed Citation Articles by Sohara, Y. Articles by DeClerck, Y. A.

Lytic Bone Lesions in Human Neuroblastoma Xenograft Involve Osteoclast Recruitment and Are Inhibited by Bisphosphonate¹

Departments of Pediatrics, Division of Hematology-Oncology [Y. S., C. P. R., Y. A. D.], Biochemistry and Molecular Biology [Y. A. D.], Pathology [H. S., C. P. R.], Radiology [M. S., H. P.], Neurosurgery [S. Y.], and Preventive Medicine [W. Y.], Childrens Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles, California 90027

Neuroblastoma is the second most common solid tumor in childhood and frequently metastasizes to the bone marrow and the bone matrix. The mechanism involved in bone metastasis and destruction in neuroblastoma is poorly understood. Using a model of bone invasion in immunodeficient mice, we demonstrated that neuroblastoma cells recruited osteoclasts to generate osteolytic lesions and invade the bone matrix. In further support of a contributory role for osteoclasts in neuroblastoma bone invasion, we demonstrated that treatment with the bisphosphonate compound, ibandronate, significantly delayed the progression of osteolytic lesions. The data suggest that bisphosphonates may be clinically effective in the treatment of bone metastases in neuroblastoma.

This article has been cited by other articles:

				Y. Fukaya, H. Shimada, L.-C. Wang, E. Zandi, and Y. A. DeClerck Identification of Galectin-3-binding Protein as a Factor Secreted by Tumor Cells That Stimulates Interleukin-6 Expression in the Bone Marrow Stroma J. Biol. Chem., July 4, 2008; 283(27): 18573 - 18581. [Abstract] [Full Text] [PDF]

				H. Peng, Y. Sohara, R. A. Moats, M. D. Nelson Jr., S. G. Groshen, W. Ye, C. P. Reynolds, and Y. A. DeClerck The Activity of Zoledronic Acid on Neuroblastoma Bone Metastasis Involves Inhibition of Osteoclasts and Tumor Cell Survival and Proliferation Cancer Res., October 1, 2007; 67(19): 9346 - 9355. [Abstract] [Full Text] [PDF]

				C. M. van Golen, T. S. Schwab, B. Kim, M. E. Soules, S. Su Oh, K. Fung, K. L. van Golen, and E. L. Feldman Insulin-Like Growth Factor-I Receptor Expression Regulates Neuroblastoma Metastasis to Bone. Cancer Res., July 1, 2006; 66(13): 6570 - 6578. [Abstract] [Full Text] [PDF]

				P. Clezardin, F. H. Ebetino, and P. G.J. Fournier Bisphosphonates and Cancer-Induced Bone Disease: Beyond Their Antiresorptive Activity Cancer Res., June 15, 2005; 65(12): 4971 - 4974. [Abstract] [Full Text] [PDF]

				S.-J. Kim, H. Uehara, S. Yazici, J. He, R. R. Langley, P. Mathew, D. Fan, and I. J. Fidler Modulation of Bone Microenvironment with Zoledronate Enhances the Therapeutic Effects of STI571 and Paclitaxel against Experimental Bone Metastasis of Human Prostate Cancer Cancer Res., May 1, 2005; 65(9): 3707 - 3715. [Abstract] [Full Text] [PDF]

				Y. Sohara, H. Shimada, C. Minkin, A. Erdreich-Epstein, J. A. Nolta, and Y. A. DeClerck Bone Marrow Mesenchymal Stem Cells Provide an Alternate Pathway of Osteoclast Activation and Bone Destruction by Cancer Cells Cancer Res., February 15, 2005; 65(4): 1129 - 1135. [Abstract] [Full Text] [PDF]

				G. Puthenveetil, J. Scholes, D. Carbonell, N. Qureshi, P. Xia, L. Zeng, S. Li, Y. Yu, A. L Hiti, J.-K. Yee, et al. Successful correction of the human {beta}-thalassemia major phenotype using a lentiviral vector Blood, December 1, 2004; 104(12): 3445 - 3453. [Abstract] [Full Text] [PDF]