| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Molecular Biology and Genetics |
Department of Human Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612
A role for allelic variation within the gene for the antioxidant selenoprotein glutathione peroxidase 1 (GPx-1) in the risk or etiology of breast cancer was investigated. By analyzing the frequency of a polymorphism within the GPx-1 gene resulting in a leucine or proline at codon 198, it was determined that the leucine-containing allele was more frequently associated with breast cancer than the proline-containing allele (odds ratio = 1.9; P < 0.05). However, the heterozygosity index for this polymorphism was lower in the breast cancer samples. To determine whether this was because of the loss of heterozygosity (LOH) during tumor development, another polymorphic marker within GPx-1, which is frequently heterozygous in the human population, was analyzed. These studies indicated that LOH at this locus is a frequent event, occurring in approximately 36% of the breast tumor DNAs analyzed. The consequences of the identity of the amino acid at position 198 were investigated by engineering breast carcinoma cells that exclusively express either the leucine- or proline-containing GPx-1 allele and studying the response to increasing concentrations of selenium. These studies indicated that the leucine-containing allele was less responsive to the stimulation of GPx-1 enzyme activity observed during selenium supplementation than the allele differing only by a proline at that position. These studies support a role for GPx-1 allelic identity and LOH as factors of significance to breast cancer development.
This article has been cited by other articles:
|
|
 |
|
  M. Farina, F. Campos, I. Vendrell, J. Berenguer, M. Barzi, S. Pons, and C. Sunol Probucol Increases Glutathione Peroxidase-1 Activity and Displays Long-Lasting Protection against Methylmercury Toxicity in Cerebellar Granule Cells Toxicol. Sci., December 1, 2009; 112(2): 416 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zhuo, M. Goldberg, L. Herman, B.-S. Lee, H. Wang, R. L. Brown, C. B. Foster, U. Peters, and A. M. Diamond Molecular Consequences of Genetic Variations in the Glutathione Peroxidase 1 Selenoenzyme Cancer Res., October 15, 2009; 69(20): 8183 - 8190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Bhatti, P. A. Stewart, A. Hutchinson, N. Rothman, M. S. Linet, P. D. Inskip, and P. Rajaraman Lead Exposure, Polymorphisms in Genes Related to Oxidative Stress, and Risk of Adult Brain Tumors Cancer Epidemiol. Biomarkers Prev., June 1, 2009; 18(6): 1841 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Grumolato, H. Ghzili, M. Montero-Hadjadje, S. Gasman, J. Lesage, Y. Tanguy, L. Galas, D. Ait-Ali, J. Leprince, N. C. Guerineau, et al. Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion FASEB J, June 1, 2008; 22(6): 1756 - 1768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E Fabre, A. Raynaud-Simon, J.-L. Golmard, M. Hebert, X. Dulcire, M. Succari, J. Myara, D. Durand, and V. Nivet-Antoine Gene polymorphisms of oxidative stress enzymes: prediction of elderly renutrition Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1504 - 1512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Juliger, H. Goenaga-Infante, T. A. Lister, J. Fitzgibbon, and S. P. Joel Chemosensitization of B-Cell Lymphomas by Methylseleninic Acid Involves Nuclear Factor-{kappa}B Inhibition and the Rapid Generation of Other Selenium Species Cancer Res., November 15, 2007; 67(22): 10984 - 10992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Mathers and J. E. Hesketh The Biological Revolution: Understanding the Impact of SNPs on Diet-Cancer Interrelationships J. Nutr., January 1, 2007; 137(1): 253S - 258S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Moghadaszadeh and A. H. Beggs Selenoproteins and Their Impact on Human Health Through Diverse Physiological Pathways. Physiology, October 1, 2006; 21(5): 307 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Karunasinghe, L. R. Ferguson, J. Tuckey, and J. Masters Hemolysate Thioredoxin Reductase and Glutathione Peroxidase Activities Correlate with Serum Selenium in a Group of New Zealand Men at High Prostate Cancer Risk J. Nutr., August 1, 2006; 136(8): 2232 - 2235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Diwadkar-Navsariwala, G. S. Prins, S. M. Swanson, L. A. Birch, V. H. Ray, S. Hedayat, D. L. Lantvit, and A. M. Diamond Selenoprotein deficiency accelerates prostate carcinogenesis in a transgenic model PNAS, May 23, 2006; 103(21): 8179 - 8184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Ravn-Haren, A. Olsen, A. Tjonneland, L. O. Dragsted, B. A. Nexo, H. Wallin, K. Overvad, O. Raaschou-Nielsen, and U. Vogel Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study Carcinogenesis, April 1, 2006; 27(4): 820 - 825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sutton, P. Nahon, D. Pessayre, P. Rufat, A. Poire, M. Ziol, D. Vidaud, N. Barget, N. Ganne-Carrie, N. Charnaux, et al. Genetic polymorphisms in antioxidant enzymes modulate hepatic iron accumulation and hepatocellular carcinoma development in patients with alcohol-induced cirrhosis. Cancer Res., March 1, 2006; 66(5): 2844 - 2852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cebrian, P. D. Pharoah, S. Ahmed, P. L. Smith, C. Luccarini, R. Luben, K. Redman, H. Munday, D. F. Easton, A. M. Dunning, et al. Tagging Single-Nucleotide Polymorphisms in Antioxidant Defense Enzymes and Susceptibility to Breast Cancer Cancer Res., January 15, 2006; 66(2): 1225 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hu, R. V. Benya, R. E. Carroll, and A. M. Diamond Allelic Loss of the Gene for the GPX1 Selenium-Containing Protein Is a Common Event in Cancer J. Nutr., December 1, 2005; 135(12): 3021S - 3024S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ahn, M. D. Gammon, R. M. Santella, M. M. Gaudet, J. A. Britton, S. L. Teitelbaum, M. B. Terry, A. I. Neugut, and C. B. Ambrosone No Association Between Glutathione Peroxidase Pro198Leu Polymorphism and Breast Cancer Risk Cancer Epidemiol. Biomarkers Prev., October 1, 2005; 14(10): 2459 - 2461. [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Carlson, X.-M. Xu, V. N. Gladyshev, and D. L. Hatfield Selective Rescue of Selenoprotein Expression in Mice Lacking a Highly Specialized Methyl Group in Selenocysteine tRNA J. Biol. Chem., February 18, 2005; 280(7): 5542 - 5548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Cox, S. E. Hankinson, P. Kraft, and D. J. Hunter No Association between GPX1 Pro198Leu and Breast Cancer Risk Cancer Epidemiol. Biomarkers Prev., November 1, 2004; 13(11): 1821 - 1822. [Full Text] [PDF]
|
|
|
|
|
|
V. Diwadkar-Navsariwala and A. M. Diamond The Link between Selenium and Chemoprevention: A Case for Selenoproteins J. Nutr., November 1, 2004; 134(11): 2899 - 2902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Diamond On the road to selenocysteine PNAS, September 14, 2004; 101(37): 13395 - 13396. [Full Text] [PDF]
|
|
|
|
|
|
J. A. Milner Molecular Targets for Bioactive Food Components J. Nutr., September 1, 2004; 134(9): 2492S - 2498S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Vogel, A. Olsen, H. Wallin, K. Overvad, A. Tjonneland, and B. A. Nexo No Association between GPX Pro198Leu and Risk of Basal Cell Carcinoma Cancer Epidemiol. Biomarkers Prev., August 1, 2004; 13(8): 1412 - 1413. [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Taylor, H. L. Parnes, and S. M. Lippman Science Peels the Onion of Selenium Effects on Prostate Carcinogenesis J Natl Cancer Inst, May 5, 2004; 96(9): 645 - 647. [Full Text] [PDF]
|
|
|
|
|
|
J. A. Milner Incorporating Basic Nutrition Science into Health Interventions for Cancer Prevention J. Nutr., November 1, 2003; 133(11): 3820S - 3826. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
