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[Cancer Research 63, 3486-3489, July 1, 2003]
© 2003 American Association for Cancer Research

Advances in Brief

Germ-line Mutations of the Macrophage Scavenger Receptor 1 Gene

Association with Prostate Cancer Risk in African-American Men1

David C. Miller, S. Lilly Zheng, Rodney L. Dunn, Aruna V. Sarma, James E. Montie, Ethan M. Lange, Deborah A. Meyers, Jianfeng Xu and Kathleen A. Cooney2

Departments of Urology [D. C. M., R. L. D., A. V. S., J. E. M., K. A. C.] and Internal Medicine [K. A. C.], University of Michigan, Medical School, Ann Arbor, Michigan 48109-0946, and Department of Public Health Sciences and Center for Human Genetics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1063 [S. L. Z., E. M. L., D. A. M., J. X.]

Both rare germ-line mutations and common sequence variants of the macrophage scavenger receptor 1 (MSR1) gene have recently been implicated as potential prostate cancer susceptibility factors. However, existing studies are limited by the referral-based nature of samples and a paucity of African-American participants. In this context, we evaluated the association of germ-line mutations and common MSR1 sequence variants with prostate cancer risk in a case control study of a community-based sample of 134 African-American men with prostate cancer and 340 unaffected controls. In our sample, the rare Asp174Tyr missense change was identified nearly twice as frequently in men with prostate cancer (6.8%) compared with unaffected controls (3.6%; P = 0.14). Moreover, significantly different allele frequencies between cases and controls were observed for one of the sequence variants, IVS5–59 (P = 0.02). Taken together, our results provide some additional support for the hypothesis that selected, rare MSR1 mutations are associated with increased prostate cancer susceptibility among African-American men.




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