Cancer Research Cancer Epigenetics EMT and Cancer Progression and Treatment
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vanaja, D. K.
Right arrow Articles by Young, C. Y. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vanaja, D. K.
Right arrow Articles by Young, C. Y. F.
[Cancer Research 63, 3877-3882, July 15, 2003]
© 2003 American Association for Cancer Research

Advances in Brief

Transcriptional Silencing of Zinc Finger Protein 185 Identified by Expression Profiling Is Associated with Prostate Cancer Progression1

Donkena Krishna Vanaja, John C. Cheville, Steve J. Iturria and Charles Y. F. Young2

Department of Urology [D. K. V., C. Y. F. Y.], Department of Laboratory Medicine and Pathology [J. C. C.], and Division of Biostatics [S. J. I.], Mayo Clinic/Foundation, Rochester, Minnesota 55905

We profiled the expression of genes in benign and untreated human prostate cancer tissues using oligonucleotide microarrays. We report here 50 genes with distinct expression patterns in metastatic and confined tumors (Gleason score 6 and 9; lymph node invasive and noninvasive). Validation of expression profiles of 6 genes by quantitative PCR revealed a strong inverse correlation in the expression of zinc finger protein 185 (ZNF185), bullous pemphigoid antigen gene (BPAG1), and prostate secretory protein (PSP94) with progression of prostate cancer. Treatment of prostate cancer cell lines with 5-aza-2'-deoxycytidine (5-Aza-CdR), an inhibitor of DNA methylation, restored ZNF185 expression levels. Moreover, methylation-specific PCR confirmed methylation of the 5'CpG islands of the ZNF185 gene in all of the metastatic tissues and 44% of the localized tumor tissues, as well as in the prostate cancer cell lines tested. Thus, transcriptional silencing of ZNF185 by methylation in prostate tumor tissues implicates the ZNF185 gene in prostate tumorigenesis.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. Condomines, D. Hose, T. Reme, G. Requirand, M. Hundemer, M. Schoenhals, H. Goldschmidt, and B. Klein
Gene Expression Profiling and Real-Time PCR Analyses Identify Novel Potential Cancer-Testis Antigens in Multiple Myeloma
J. Immunol., July 15, 2009; 183(2): 832 - 840.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Lou, M. Yeager, H. Li, J. G. Bosquet, R. B. Hayes, N. Orr, K. Yu, A. Hutchinson, K. B. Jacobs, P. Kraft, et al.
Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility
PNAS, May 12, 2009; 106(19): 7933 - 7938.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. D. Sorensen, P. J. Wild, A. Mortezavi, K. Adolf, N. Torring, S. Heeboll, B. P. Ulhoi, P. Ottosen, T. Sulser, T. Hermanns, et al.
Genetic and Epigenetic SLC18A2 Silencing in Prostate Cancer Is an Independent Adverse Predictor of Biochemical Recurrence after Radical Prostatectomy
Clin. Cancer Res., February 15, 2009; 15(4): 1400 - 1410.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Madar, R. Brosh, Y. Buganim, O. Ezra, I. Goldstein, H. Solomon, I. Kogan, N. Goldfinger, H. Klocker, and V. Rotter
Modulated expression of WFDC1 during carcinogenesis and cellular senescence
Carcinogenesis, January 1, 2009; 30(1): 20 - 27.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
Y. Zhang, D. Linn, Z. Liu, J. Melamed, F. Tavora, C. Y. Young, A. M. Burger, and A. W. Hamburger
EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance
Mol. Cancer Ther., October 1, 2008; 7(10): 3176 - 3186.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. E. Helgeson, S. A. Tomlins, N. Shah, B. Laxman, Q. Cao, J. R. Prensner, X. Cao, N. Singla, J. E. Montie, S. Varambally, et al.
Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 Gene Fusions in Prostate Cancer
Cancer Res., January 1, 2008; 68(1): 73 - 80.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Fischer, A. Oberthuer, B. Brors, Y. Kahlert, M. Skowron, H. Voth, P. Warnat, K. Ernestus, B. Hero, and F. Berthold
Differential Expression of Neuronal Genes Defines Subtypes of Disseminated Neuroblastoma with Favorable and Unfavorable Outcome
Clin. Cancer Res., September 1, 2006; 12(17): 5118 - 5128.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
A. S Perry, R. Foley, K. Woodson, and M. Lawler
The emerging roles of DNA methylation in the clinical management of prostate cancer.
Endocr. Relat. Cancer, June 1, 2006; 13(2): 357 - 377.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. K. Vanaja, K. V. Ballman, B. W. Morlan, J. C. Cheville, R. M. Neumann, M. M. Lieber, D. J. Tindall, and C. Y.F. Young
PDLIM4 Repression by Hypermethylation as a Potential Biomarker for Prostate Cancer
Clin. Cancer Res., February 15, 2006; 12(4): 1128 - 1136.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. J.M. Best, J. W. Gillespie, Y. Yi, G. V.R. Chandramouli, M. A. Perlmutter, Y. Gathright, H. S. Erickson, L. Georgevich, M. A. Tangrea, P. H. Duray, et al.
Molecular Alterations in Primary Prostate Cancer after Androgen Ablation Therapy
Clin. Cancer Res., October 1, 2005; 11(19): 6823 - 6834.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Lodygin, A. Epanchintsev, A. Menssen, J. Diebold, and H. Hermeking
Functional Epigenomics Identifies Genes Frequently Silenced in Prostate Cancer
Cancer Res., May 15, 2005; 65(10): 4218 - 4227.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
P. P. Medina, J. Carretero, E. Ballestar, B. Angulo, F. Lopez-Rios, M. Esteller, and M. Sanchez-Cespedes
Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells
Hum. Mol. Genet., April 1, 2005; 14(7): 973 - 982.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
Y. P. Yu, S. Paranjpe, J. Nelson, S. Finkelstein, B. Ren, D. Kokkinakis, G. Michalopoulos, and J.-H. Luo
High throughput screening of methylation status of genes in prostate cancer using an oligonucleotide methylation array
Carcinogenesis, February 1, 2005; 26(2): 471 - 479.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Wong, K. Y-Y. Chan, P. F. Macgregor, P. B-S. Lai, J. A. Squire, B. Beheshti, M. Albert, and T. W-T. Leung
Transcriptional Profiling Identifies Gene Expression Changes Associated with IFN-{alpha} Tolerance in Hepatitis C-Related Hepatocellular Carcinoma Cells
Clin. Cancer Res., February 1, 2005; 11(3): 1319 - 1326.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
C.E. Hoei-Hansen, J.E. Nielsen, K. Almstrup, M.A. Hansen, N.E. Skakkebaek, E. Rajpert-DeMeyts, and H. Leffers
Identification of genes differentially expressed in testes containing carcinoma in situ
Mol. Hum. Reprod., June 1, 2004; 10(6): 423 - 431.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2003 by the American Association for Cancer Research.