Cancer Research Targets Advances in Breast Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jin, S.
Right arrow Articles by Hua, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jin, S.
Right arrow Articles by Hua, X.
[Cancer Research 63, 4204-4210, July 15, 2003]
© 2003 American Association for Cancer Research

Tumor Biology

Menin Associates with FANCD2, a Protein Involved in Repair of DNA Damage1

Shenghao Jin2, Hua Mao2, Robert W. Schnepp, Stephen M. Sykes, Albert C. Silva, Alan D. D’Andrea and Xianxin Hua3

Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160 [S. J., H. M., R. W. S., S. M. S., A. C. S., X. H.], and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 02115 [A. D. D.]

Multiple endocrine neoplasia type I (MEN1) is an inherited tumor syndrome characterized by tumors in multiple endocrine organs including the parathyroids, pancreatic islets, and the pituitary. The gene mutated in MEN1 patients, Men1, encodes a protein of 610 amino acid residues, menin, and mutations in the Men1 gene lead to the MEN1 syndrome. Although the chromosomal instability in the peripheral lymphocytes from the MEN1 patients has been reported previously, it is not clear whether menin is involved in repair of DNA damage. Here we show that menin specifically interacts with FANCD2, a protein encoded by a gene involved in DNA repair and mutated in patients with an inherited cancer-prone syndrome, Fanconi anemia. The interaction between menin and FANCD2 is enhanced by {gamma}-irradiation. Moreover, loss of menin expression in mouse embryonic fibroblasts leads to increased sensitivity to DNA damage. Furthermore, menin is localized to chromatin and nuclear matrix, and the association with nuclear matrix is enhanced by {gamma}-irradiation. Together, these results suggest that menin plays a critical role in repair of DNA damage in concert with FANCD2.




This article has been cited by other articles:


Home page
 BloodHome page
R. Popovic, L. E. Riesbeck, C. S. Velu, A. Chaubey, J. Zhang, N. J. Achille, F. E. Erfurth, K. Eaton, J. Lu, H. L. Grimes, et al.
Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization
Blood, April 2, 2009; 113(14): 3314 - 3322.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. La, Y. Yang, S. K. Karnik, A. C. Silva, R. W. Schnepp, S. K. Kim, and X. Hua
Menin-mediated Caspase 8 Expression in Suppressing Multiple Endocrine Neoplasia Type 1
J. Biol. Chem., October 26, 2007; 282(43): 31332 - 31340.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
Y M H Jonkers, S M H Claessen, A Perren, A M Schmitt, L J Hofland, W de Herder, R R de Krijger, A A J Verhofstad, A R Hermus, J A Kummer, et al.
DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients
Endocr. Relat. Cancer, September 1, 2007; 14(3): 769 - 779.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
L. E. MacConaill, C. M. Hughes, O. Rozenblatt-Rosen, S. Nannepaga, and M. Meyerson
Phosphorylation of the Menin Tumor Suppressor Protein on Serine 543 and Serine 583
Mol. Cancer Res., October 1, 2006; 4(10): 793 - 801.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. Busygina, M. C. Kottemann, K. L. Scott, S. E. Plon, and A. E. Bale
Multiple Endocrine Neoplasia Type 1 Interacts with Forkhead Transcription Factor CHES1 in DNA Damage Response.
Cancer Res., September 1, 2006; 66(17): 8397 - 8403.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. W. Schnepp, Y.-X. Chen, H. Wang, T. Cash, A. Silva, J. A. Diehl, E. Brown, and X. Hua
Mutation of Tumor Suppressor Gene Men1 Acutely Enhances Proliferation of Pancreatic Islet Cells
Cancer Res., June 1, 2006; 66(11): 5707 - 5715.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y.-X. Chen, J. Yan, K. Keeshan, A. T. Tubbs, H. Wang, A. Silva, E. J. Brown, J. L. Hess, W. S. Pear, and X. Hua
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression
PNAS, January 24, 2006; 103(4): 1018 - 1023.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Zhang, R. Kaur, X. Lu, X. Shen, L. Li, and R. J. Legerski
The Pso4 mRNA Splicing and DNA Repair Complex Interacts with WRN for Processing of DNA Interstrand Cross-links
J. Biol. Chem., December 9, 2005; 280(49): 40559 - 40567.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Papaconstantinou, Y. Wu, H. N. Pretorius, N. Singh, G. Gianfelice, R. M. Tanguay, A. R. Campos, and P.-A. Bedard
Menin Is a Regulator of the Stress Response in Drosophila melanogaster
Mol. Cell. Biol., November 15, 2005; 25(22): 9960 - 9972.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. K. Karnik, C. M. Hughes, X. Gu, O. Rozenblatt-Rosen, G. W. McLean, Y. Xiong, M. Meyerson, and S. K. Kim
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c
PNAS, October 11, 2005; 102(41): 14659 - 14664.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. A. Milne, C. M. Hughes, R. Lloyd, Z. Yang, O. Rozenblatt-Rosen, Y. Dou, R. W. Schnepp, C. Krankel, V. A. LiVolsi, D. Gibbs, et al.
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors
PNAS, January 18, 2005; 102(3): 749 - 754.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. La, A. C. Silva, Z. Hou, H. Wang, R. W. Schnepp, N. Yan, Y. Shi, and X. Hua
Direct Binding of DNA by Tumor Suppressor Menin
J. Biol. Chem., November 19, 2004; 279(47): 49045 - 49054.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. C. Scacheri, A. L. Kennedy, K. Chin, M. T. Miller, J. G. Hodgson, J. W. Gray, S. J. Marx, A. M. Spiegel, and F. S. Collins
Pancreatic Insulinomas in Multiple Endocrine Neoplasia, Type I Knockout Mice Can Develop in the Absence of Chromosome Instability or Microsatellite Instability
Cancer Res., October 1, 2004; 64(19): 7039 - 7044.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
V. Busygina, K. Suphapeetiporn, L. R. Marek, R. S. Stowers, T. Xu, and A. E. Bale
Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1
Hum. Mol. Genet., October 1, 2004; 13(20): 2399 - 2408.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. W. Schnepp, Z. Hou, H. Wang, C. Petersen, A. Silva, H. Masai, and X. Hua
Functional Interaction between Tumor Suppressor Menin and Activator of S-Phase Kinase
Cancer Res., September 15, 2004; 64(18): 6791 - 6796.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
R. Larder, L. Chang, M. Clinton, and P. Brown
Gonadotropin-Releasing Hormone Regulates Expression of the DNA Damage Repair Gene, Fanconi anemia A, in Pituitary Gonadotroph Cells
Biol Reprod, September 1, 2004; 71(3): 828 - 836.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Yokoyama, Z. Wang, J. Wysocka, M. Sanyal, D. J. Aufiero, I. Kitabayashi, W. Herr, and M. L. Cleary
Leukemia Proto-Oncoprotein MLL Forms a SET1-Like Histone Methyltransferase Complex with Menin To Regulate Hox Gene Expression
Mol. Cell. Biol., July 1, 2004; 24(13): 5639 - 5649.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. La, R. W. Schnepp, C. D. Petersen, A. C. Silva, and X. Hua
Tumor Suppressor Menin Regulates Expression of Insulin-Like Growth Factor Binding Protein 2
Endocrinology, July 1, 2004; 145(7): 3443 - 3450.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. A. Biondi, M. G. Gartside, P. Waring, K. A. Loffler, M. S. Stark, M. A. Magnuson, G. F. Kay, and N. K. Hayward
Conditional Inactivation of the Men1 Gene Leads to Pancreatic and Pituitary Tumorigenesis but Does Not Affect Normal Development of These Tissues
Mol. Cell. Biol., April 15, 2004; 24(8): 3125 - 3131.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. W. Schnepp, H. Mao, S. M. Sykes, W.-X. Zong, A. Silva, P. La, and X. Hua
Menin Induces Apoptosis in Murine Embryonic Fibroblasts
J. Biol. Chem., March 12, 2004; 279(11): 10685 - 10691.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2003 by the American Association for Cancer Research.