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[Cancer Research 63, 4204-4210, July 15, 2003]
© 2003 American Association for Cancer Research

Tumor Biology

Menin Associates with FANCD2, a Protein Involved in Repair of DNA Damage1

Shenghao Jin2, Hua Mao2, Robert W. Schnepp, Stephen M. Sykes, Albert C. Silva, Alan D. D’Andrea and Xianxin Hua3

Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160 [S. J., H. M., R. W. S., S. M. S., A. C. S., X. H.], and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 02115 [A. D. D.]

Multiple endocrine neoplasia type I (MEN1) is an inherited tumor syndrome characterized by tumors in multiple endocrine organs including the parathyroids, pancreatic islets, and the pituitary. The gene mutated in MEN1 patients, Men1, encodes a protein of 610 amino acid residues, menin, and mutations in the Men1 gene lead to the MEN1 syndrome. Although the chromosomal instability in the peripheral lymphocytes from the MEN1 patients has been reported previously, it is not clear whether menin is involved in repair of DNA damage. Here we show that menin specifically interacts with FANCD2, a protein encoded by a gene involved in DNA repair and mutated in patients with an inherited cancer-prone syndrome, Fanconi anemia. The interaction between menin and FANCD2 is enhanced by {gamma}-irradiation. Moreover, loss of menin expression in mouse embryonic fibroblasts leads to increased sensitivity to DNA damage. Furthermore, menin is localized to chromatin and nuclear matrix, and the association with nuclear matrix is enhanced by {gamma}-irradiation. Together, these results suggest that menin plays a critical role in repair of DNA damage in concert with FANCD2.




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