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[Cancer Research 63, 5679-5684, September 15, 2003]
© 2003 American Association for Cancer Research

Advances in Brief

Molecular Signature Associated with Bone Marrow Micrometastasis in Human Breast Cancer1

Ute Woelfle2, Jacqueline Cloos2, Guido Sauter, Lutz Riethdorf, Fritz Jänicke, Paul van Diest, Ruud Brakenhoff and Klaus Pantel3

Institute of Tumor Biology [U. W., K. P.], Department of Gynecology [F. J.], and Department of Gynecopathology [L. R.], University Hospital Hamburg-Eppendorf, D-20246 Hamburg, Germany; Section Tumor Biology [J. C., R. B.], Department of Otolaryngology/Head-Neck Surgery and Department of Pathology [P. v. D.], Vrije Universiteit Medical Center, 1071 HV Amsterdam, the Netherlands; and Department of Pathology [G. S.] University of Basel, CH-4003 Basel, Switzerland

Metastasis is the leading cause of cancer-related death, and bone marrow (BM) is a prominent metastatic site in solid tumors. Here, we focused on the onset of metastasis, using BM as an indicator organ for micrometastatic tumor cells in breast cancer patients without overt metastases (tumor-node-metastasis stage M0). Expression analysis with cDNA arrays showed distinct profiles between primary tumors from BM-positive and BM-negative patients. The differentially expressed genes are involved in extracellular matrix remodeling, adhesion, cytoskeleton plasticity, and signal transduction (in particular RAS and hypoxia-inducible factor 1{alpha} pathway). The BM signature was mainly characterized by transcriptional repression and different from the expression signature associated with lymphatic metastasis. Thus, BM micrometastasis is a selective process with a specific molecular signature of the primary tumor.




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Copyright © 2003 by the American Association for Cancer Research.