Cancer Research Annual Meeting 2010  Jordan
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Singh, S. K.
Right arrow Articles by Dirks, P. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Singh, S. K.
Right arrow Articles by Dirks, P. B.
[Cancer Research 63, 5821-5828, September 15, 2003]
© 2003 American Association for Cancer Research


Regular Articles

Identification of a Cancer Stem Cell in Human Brain Tumors

Sheila K. Singh, Ian D. Clarke, Mizuhiko Terasaki, Victoria E. Bonn, Cynthia Hawkins, Jeremy Squire and Peter B. Dirks

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada [S. K. S., I. D. C., M. T., V. E. B., P. B. D.], and Program in Developmental Biology [S. K. S., I. D. C., M. T., V. E. B., P. B. D.], Division of Neurosurgery [S. K. S., P. B. D.], Department of Pediatric Laboratory Medicine [C. H.], and Department of Laboratory Medicine and Pathobiology [J. S.], University of Toronto, Toronto, Ontario M5G 1X8 Canada

Most current research on human brain tumors is focused on the molecular and cellular analysis of the bulk tumor mass. However, there is overwhelming evidence in some malignancies that the tumor clone is heterogeneous with respect to proliferation and differentiation. In human leukemia, the tumor clone is organized as a hierarchy that originates from rare leukemic stem cells that possess extensive proliferative and self-renewal potential, and are responsible for maintaining the tumor clone. We report here the identification and purification of a cancer stem cell from human brain tumors of different phenotypes that possesses a marked capacity for proliferation, self-renewal, and differentiation. The increased self-renewal capacity of the brain tumor stem cell (BTSC) was highest from the most aggressive clinical samples of medulloblastoma compared with low-grade gliomas. The BTSC was exclusively isolated with the cell fraction expressing the neural stem cell surface marker CD133. These CD133+ cells could differentiate in culture into tumor cells that phenotypically resembled the tumor from the patient. The identification of a BTSC provides a powerful tool to investigate the tumorigenic process in the central nervous system and to develop therapies targeted to the BTSC.




This article has been cited by other articles:


Home page
Genes Dev.Home page
R. A. Neumuller and J. A. Knoblich
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer
Genes & Dev., December 1, 2009; 23(23): 2675 - 2699.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S. A. Hubbard, A. M. Friel, B. Kumar, L. Zhang, B. R. Rueda, and C. E. Gargett
Evidence for Cancer Stem Cells in Human Endometrial Carcinoma
Cancer Res., November 1, 2009; 69(21): 8241 - 8248.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
F. Barbieri, A. Pattarozzi, M. Gatti, C. Aiello, A. Quintero, G. Lunardi, A. Bajetto, A. Ferrari, M. D. Culler, and T. Florio
Differential efficacy of SSTR1, -2, and -5 agonists in the inhibition of C6 glioma growth in nude mice
Am J Physiol Endocrinol Metab, November 1, 2009; 297(5): E1078 - E1088.
[Abstract] [Full Text] [PDF]


Home page
Mol Cancer ResHome page
M. Monticone, E. Biollo, A. Fabiano, M. Fabbi, A. Daga, F. Romeo, M. Maffei, A. Melotti, W. Giaretti, G. Corte, et al.
z-Leucinyl-Leucinyl-Norleucinal Induces Apoptosis of Human Glioblastoma Tumor-Initiating Cells by Proteasome Inhibition and Mitotic Arrest Response
Mol. Cancer Res., November 1, 2009; 7(11): 1822 - 1834.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. E. Carpentino, M. J. Hynes, H. D. Appelman, T. Zheng, D. A. Steindler, E. W. Scott, and E. H. Huang
Aldehyde Dehydrogenase-Expressing Colon Stem Cells Contribute to Tumorigenesis in the Transition from Colitis to Cancer
Cancer Res., October 15, 2009; 69(20): 8208 - 8215.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
T. Hide, T. Takezaki, Y. Nakatani, H. Nakamura, J.-i. Kuratsu, and T. Kondo
Sox11 Prevents Tumorigenesis of Glioma-Initiating Cells by Inducing Neuronal Differentiation
Cancer Res., October 15, 2009; 69(20): 7953 - 7959.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
K. A. Hassan, G. Chen, G. P. Kalemkerian, M. S. Wicha, and D. G. Beer
An Embryonic Stem Cell-Like Signature Identifies Poorly Differentiated Lung Adenocarcinoma but not Squamous Cell Carcinoma
Clin. Cancer Res., October 15, 2009; 15(20): 6386 - 6390.
[Abstract] [Full Text] [PDF]


Home page
Mayo Clin Proc.Home page
B. J. Gersh, R. D. Simari, A. Behfar, C. M. Terzic, and A. Terzic
Cardiac Cell Repair Therapy: A Clinical Perspective
Mayo Clin. Proc., October 1, 2009; 84(10): 876 - 892.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
H. Haeno, R. L. Levine, D. G. Gilliland, and F. Michor
A progenitor cell origin of myeloid malignancies
PNAS, September 29, 2009; 106(39): 16616 - 16621.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
G. Bertolini, L. Roz, P. Perego, M. Tortoreto, E. Fontanella, L. Gatti, G. Pratesi, A. Fabbri, F. Andriani, S. Tinelli, et al.
Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
PNAS, September 22, 2009; 106(38): 16281 - 16286.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
S. H. Schilling, A. B. Hjelmeland, D. R. Radiloff, I. M. Liu, T. P. Wakeman, J. R. Fielhauer, E. H. Foster, J. D. Lathia, J. N. Rich, X.-F. Wang, et al.
NDRG4 Is Required for Cell Cycle Progression and Survival in Glioblastoma Cells
J. Biol. Chem., September 11, 2009; 284(37): 25160 - 25169.
[Abstract] [Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
V. Tirino, R. Camerlingo, R. Franco, D. Malanga, A. La Rocca, G. Viglietto, G. Rocco, and G. Pirozzi
The role of CD133 in the identification and characterisation of tumour-initiating cells in non-small-cell lung cancer
Eur. J. Cardiothorac. Surg., September 1, 2009; 36(3): 446 - 453.
[Abstract] [Full Text] [PDF]


Home page
Vet PatholHome page
M. J. Hynes, K. M. Huang, and E. H. Huang
REVIEW PAPER: Implications of the "Cancer Stem Cell" Hypothesis on Murine Models of Colon Cancer and Colitis-associated Cancer
Vet. Pathol., September 1, 2009; 46(5): 819 - 835.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
A. M. McCord, M. Jamal, E. S. Williams, K. Camphausen, and P. J. Tofilon
CD133+ Glioblastoma Stem-like Cells are Radiosensitive with a Defective DNA Damage Response Compared with Established Cell Lines
Clin. Cancer Res., August 15, 2009; 15(16): 5145 - 5153.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
J. J. Short and D. T. Curiel
Oncolytic adenoviruses targeted to cancer stem cells
Mol. Cancer Ther., August 1, 2009; 8(8): 2096 - 2102.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
M. Abdouh, S. Facchino, W. Chatoo, V. Balasingam, J. Ferreira, and G. Bernier
BMI1 Sustains Human Glioblastoma Multiforme Stem Cell Renewal
J. Neurosci., July 15, 2009; 29(28): 8884 - 8896.
[Abstract] [Full Text] [PDF]


Home page
Int ImmunolHome page
G. Pietra, C. Manzini, M. Vitale, M. Balsamo, E. Ognio, M. Boitano, P. Queirolo, L. Moretta, and M. C. Mingari
Natural killer cells kill human melanoma cells with characteristics of cancer stem cells
Int. Immunol., July 1, 2009; 21(7): 793 - 801.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
S. Rutella, G. Bonanno, A. Procoli, A. Mariotti, M. Corallo, M. G. Prisco, A. Eramo, C. Napoletano, D. Gallo, A. Perillo, et al.
Cells with Characteristics of Cancer Stem/Progenitor Cells Express the CD133 Antigen in Human Endometrial Tumors
Clin. Cancer Res., July 1, 2009; 15(13): 4299 - 4311.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
R. J. Ward, L. Lee, K. Graham, T. Satkunendran, K. Yoshikawa, E. Ling, L. Harper, R. Austin, E. Nieuwenhuis, I. D. Clarke, et al.
Multipotent CD15+ Cancer Stem Cells in Patched-1-Deficient Mouse Medulloblastoma
Cancer Res., June 1, 2009; 69(11): 4682 - 4690.
[Abstract] [Full Text] [PDF]


Home page
Mol Cancer ResHome page
J.-P. Kilday, R. Rahman, S. Dyer, L. Ridley, J. Lowe, B. Coyle, and R. Grundy
Pediatric Ependymoma: Biological Perspectives
Mol. Cancer Res., June 1, 2009; 7(6): 765 - 786.
[Abstract] [Full Text] [PDF]


Home page
Vet PatholHome page
G. Stoica, G. Lungu, H. Martini-Stoica, S. Waghela, J. Levine, and R. Smith
Identification of Cancer Stem Cells in Dog Glioblastoma
Vet. Pathol., May 1, 2009; 46(3): 391 - 406.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
E. H. Huang, M. J. Hynes, T. Zhang, C. Ginestier, G. Dontu, H. Appelman, J. Z. Fields, M. S. Wicha, and B. M. Boman
Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis
Cancer Res., April 15, 2009; 69(8): 3382 - 3389.
[Abstract] [Full Text] [PDF]


Home page
Mol Cancer ResHome page
A. M. McCord, M. Jamal, U. T. Shankavarum, F. F. Lang, K. Camphausen, and P. J. Tofilon
Physiologic Oxygen Concentration Enhances the Stem-Like Properties of CD133+ Human Glioblastoma Cells In vitro
Mol. Cancer Res., April 1, 2009; 7(4): 489 - 497.
[Abstract] [Full Text] [PDF]


Home page
IOVSHome page
M. M. S. Balla, G. K. Vemuganti, C. Kannabiran, S. G. Honavar, and R. Murthy
Phenotypic Characterization of Retinoblastoma for the Presence of Putative Cancer Stem-like Cell Markers by Flow Cytometry
Invest. Ophthalmol. Vis. Sci., April 1, 2009; 50(4): 1506 - 1514.
[Abstract] [Full Text] [PDF]


Home page
Cold Spring Harb Symp Quant BiolHome page
J.N. Rich and C.E. Eyler
Cancer Stem Cells in Brain Tumor Biology
Cold Spring Harb Symp Quant Biol, March 27, 2009; (2009) sqb.2008.73.060v1.
[Abstract] [PDF]


Home page
J. Biol. Chem.Home page
F. Griffero, A. Daga, D. Marubbi, M. C. Capra, A. Melotti, A. Pattarozzi, M. Gatti, A. Bajetto, C. Porcile, F. Barbieri, et al.
Different Response of Human Glioma Tumor-initiating Cells to Epidermal Growth Factor Receptor Kinase Inhibitors
J. Biol. Chem., March 13, 2009; 284(11): 7138 - 7148.
[Abstract] [Full Text] [PDF]


Home page
Vet PatholHome page
J. E. Trosko
REVIEW PAPER: Cancer Stem Cells and Cancer Nonstem Cells: From Adult Stem Cells or from Reprogramming of Differentiated Somatic Cells
Vet. Pathol., March 1, 2009; 46(2): 176 - 193.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M.-L. Suva, N. Riggi, J.-C. Stehle, K. Baumer, S. Tercier, J.-M. Joseph, D. Suva, V. Clement, P. Provero, L. Cironi, et al.
Identification of Cancer Stem Cells in Ewing's Sarcoma
Cancer Res., March 1, 2009; 69(5): 1776 - 1781.
[Abstract] [Full Text] [PDF]


Home page
Reproductive SciencesHome page
Hongling Du and H. S. Taylor
Reviews: Stem Cells and Female Reproduction
Reproductive Sciences, February 1, 2009; 16(2): 126 - 139.
[Abstract] [PDF]


Home page
J. Neurophysiol.Home page
C. W. Habela, N. J. Ernest, A. F. Swindall, and H. Sontheimer
Chloride Accumulation Drives Volume Dynamics Underlying Cell Proliferation and Migration
J Neurophysiol, February 1, 2009; 101(2): 750 - 757.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
T. Jiang, B. J. Collins, N. Jin, D. N. Watkins, M. V. Brock, W. Matsui, B. D. Nelkin, and D. W. Ball
Achaete-Scute Complex Homologue 1 Regulates Tumor-Initiating Capacity in Human Small Cell Lung Cancer
Cancer Res., February 1, 2009; 69(3): 845 - 854.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
S. Ando, R. Abe, M. Sasaki, J. Murata, D. Inokuma, and H. Shimizu
Bone Marrow-Derived Cells Are Not the Origin of the Cancer Stem Cells in Ultraviolet-Induced Skin Cancer
Am. J. Pathol., February 1, 2009; 174(2): 595 - 601.
[Abstract] [Full Text] [PDF]


Home page
Cancer Genomics ProteomicsHome page
I. L. BOTCHKINA, R. A. ROWEHL, D. E. RIVADENEIRA, M. S. KARPEH JR., H. CRAWFORD, A. DUFOUR, J. JU, Y. WANG, Y. LEYFMAN, and G. I. BOTCHKINA
Phenotypic Subpopulations of Metastatic Colon Cancer Stem Cells: Genomic Analysis
Cancer Genomics Proteomics, January 1, 2009; 6(1): 19 - 29.
[Abstract] [Full Text] [PDF]


Home page
Neuro Oncol DukeHome page
L. Li, A. Dutra, E. Pak, J. E. Labrie III, R. M. Gerstein, P. P. Pandolfi, L. D. Recht, and A. H. Ross
EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors
Neuro-oncol, January 1, 2009; 11(1): 9 - 21.
[Abstract] [Full Text] [PDF]


Home page
Neuro Oncol DukeHome page
C. M.-E. Sauvageot, J. L. Weatherbee, S. Kesari, S. E. Winters, J. Barnes, J. Dellagatta, N. R. Ramakrishna, C. D. Stiles, A. L.-J. Kung, M. W. Kieran, et al.
Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells
Neuro-oncol, January 1, 2009; 11(2): 109 - 121.
[Abstract] [Full Text] [PDF]


Home page
Am Soc Clin Oncol Ed BookHome page
L. Miele, N. Takebe, and S. P. Ivy
The Cancer Stem Cell Hypothesis, Embryonic Signaling Pathways, and Therapeutics: Targeting an Elusive Concept
ASCO Educational Book, January 1, 2009; 2009(1): 145 - 156.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M. A. Harris, H. Yang, B. E. Low, J. Mukherje, A. Guha, R. T. Bronson, L. D. Shultz, M. A. Israel, and K. Yun
Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma
Cancer Res., December 15, 2008; 68(24): 10051 - 10059.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
R. Pallini, L. Ricci-Vitiani, G. L. Banna, M. Signore, D. Lombardi, M. Todaro, G. Stassi, M. Martini, G. Maira, L. M. Larocca, et al.
Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme
Clin. Cancer Res., December 15, 2008; 14(24): 8205 - 8212.
[Abstract] [Full Text] [PDF]


Home page
Cold Spring Harb Symp Quant BiolHome page
T.J. Pierfelice, K.C. Schreck, C.G. Eberhart, and N. Gaiano
Notch, Neural Stem Cells, and Brain Tumors
Cold Spring Harb Symp Quant Biol, November 19, 2008; (2008) sqb.2008.73.013v2.
[Abstract] [PDF]


Home page
Clin. Cancer Res.Home page
L. Du, H. Wang, L. He, J. Zhang, B. Ni, X. Wang, H. Jin, N. Cahuzac, M. Mehrpour, Y. Lu, et al.
CD44 is of Functional Importance for Colorectal Cancer Stem Cells
Clin. Cancer Res., November 1, 2008; 14(21): 6751 - 6760.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
I. L. Weissman and J. A. Shizuru
The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases
Blood, November 1, 2008; 112(9): 3543 - 3553.
[Abstract] [Full Text] [PDF]


Home page
J Child NeurolHome page
B. A. Emmenegger and R. J. Wechsler-Reya
Stem Cells and the Origin and Propagation of Brain Tumors
J Child Neurol, October 1, 2008; 23(10): 1172 - 1178.
[Abstract] [PDF]


Home page
J Child NeurolHome page
S. L. Tye, A. G. Gilg, L. B. Tolliver, W. G. Wheeler, B. P. Toole, and B. L. Maria
Hyaluronan Regulates Ceruloplasmin Production By Gliomas and Their Treatment-Resistant Multipotent Progenitors
J Child Neurol, October 1, 2008; 23(10): 1221 - 1230.
[Abstract] [PDF]


Home page
Cancer Res.Home page
J. M. Yi, H.-C. Tsai, S. C. Glockner, S. Lin, J. E. Ohm, H. Easwaran, C. D. James, J. F. Costello, G. Riggins, C. G. Eberhart, et al.
Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma Tumors
Cancer Res., October 1, 2008; 68(19): 8094 - 8103.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
B. Bussolati, S. Bruno, C. Grange, U. Ferrando, and G. Camussi
Identification of a tumor-initiating stem cell population in human renal carcinomas
FASEB J, October 1, 2008; 22(10): 3696 - 3705.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
C. W. Habela, M. L. Olsen, and H. Sontheimer
ClC3 Is a Critical Regulator of the Cell Cycle in Normal and Malignant Glial Cells
J. Neurosci., September 10, 2008; 28(37): 9205 - 9217.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. Odoux, H. Fohrer, T. Hoppo, L. Guzik, D. B. Stolz, D. W. Lewis, S. M. Gollin, T. C. Gamblin, D. A. Geller, and E. Lagasse
A Stochastic Model for Cancer Stem Cell Origin in Metastatic Colon Cancer
Cancer Res., September 1, 2008; 68(17): 6932 - 6941.
[Abstract] [Full Text] [PDF]


Home page
Mol. Interv.Home page
B. T. Kawasaki, E. M. Hurt, T. Mistree, and W. L. Farrar
Targeting Cancer Stem Cells with Phytochemicals
Mol. Interv., August 1, 2008; 8(4): 174 - 184.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S. Bao, Q. Wu, Z. Li, S. Sathornsumetee, H. Wang, R. E. McLendon, A. B. Hjelmeland, and J. N. Rich
Targeting Cancer Stem Cells through L1CAM Suppresses Glioma Growth
Cancer Res., August 1, 2008; 68(15): 6043 - 6048.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
D. Beier, S. Rohrl, D. R. Pillai, S. Schwarz, L. A. Kunz-Schughart, P. Leukel, M. Proescholdt, A. Brawanski, U. Bogdahn, A. Trampe-Kieslich, et al.
Temozolomide Preferentially Depletes Cancer Stem Cells in Glioblastoma
Cancer Res., July 15, 2008; 68(14): 5706 - 5715.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
P. Monfared, A. Winkeler, M. Klein, H. Li, A. Klose, M. Hoesel, Y. Waerzeggers, S. Korsching, and A. H. Jacobs
Noninvasive Assessment of E2F-1-Mediated Transcriptional Regulation In vivo
Cancer Res., July 15, 2008; 68(14): 5932 - 5940.
[Abstract] [Full Text] [PDF]


Home page
Arch NeurolHome page
H. Colman and K. Aldape
Molecular Predictors in Glioblastoma: Toward Personalized Therapy
Arch Neurol, July 1, 2008; 65(7): 877 - 883.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
S.-H. Chiou, C.-C. Yu, C.-Y. Huang, S.-C. Lin, C.-J. Liu, T.-H. Tsai, S.-H. Chou, C.-S. Chien, H.-H. Ku, and J.-F. Lo
Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High-Grade Oral Squamous Cell Carcinoma
Clin. Cancer Res., July 1, 2008; 14(13): 4085 - 4095.
[Abstract] [Full Text] [PDF]


Home page
Mayo Clin Proc.Home page
A. Sekulic, P. Haluska Jr, A. J. Miller, J. G. De Lamo, S. Ejadi, J. S. Pulido, D. R. Salomao, E. C. Thorland, R. G. Vile, D. L. Swanson, et al.
Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape
Mayo Clin. Proc., July 1, 2008; 83(7): 825 - 846.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
B. M. Boman and M. S. Wicha
Cancer Stem Cells: A Step Toward the Cure
J. Clin. Oncol., June 10, 2008; 26(17): 2795 - 2799.
[Full Text] [PDF]


Home page
JCOHome page
X. Fan and C. G. Eberhart
Medulloblastoma Stem Cells
J. Clin. Oncol., June 10, 2008; 26(17): 2821 - 2827.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
B. M. Boman and E. Huang
Human Colon Cancer Stem Cells: A New Paradigm in Gastrointestinal Oncology
J. Clin. Oncol., June 10, 2008; 26(17): 2828 - 2838.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
C. E. Eyler and J. N. Rich
Survival of the Fittest: Cancer Stem Cells in Therapeutic Resistance and Angiogenesis
J. Clin. Oncol., June 10, 2008; 26(17): 2839 - 2845.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
F. Michor
Mathematical Models of Cancer Stem Cells
J. Clin. Oncol., June 10, 2008; 26(17): 2854 - 2861.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
N. J. Maitland and A. T. Collins
Prostate Cancer Stem Cells: A New Target for Therapy
J. Clin. Oncol., June 10, 2008; 26(17): 2862 - 2870.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
M. E.P. Prince and L. E. Ailles
Cancer Stem Cells in Head and Neck Squamous Cell Cancer
J. Clin. Oncol., June 10, 2008; 26(17): 2871 - 2875.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
S. Takaishi, T. Okumura, and T. C. Wang
Gastric Cancer Stem Cells
J. Clin. Oncol., June 10, 2008; 26(17): 2876 - 2882.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
C. D. Peacock and D. N. Watkins
Cancer Stem Cells and the Ontogeny of Lung Cancer
J. Clin. Oncol., June 10, 2008; 26(17): 2883 - 2889.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
L. S. Hart and W. S. El-Deiry
Invincible, but Not Invisible: Imaging Approaches Toward In Vivo Detection of Cancer Stem Cells
J. Clin. Oncol., June 10, 2008; 26(17): 2901 - 2910.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
P. B. Dirks
Brain Tumor Stem Cells: Bringing Order to the Chaos of Brain Cancer
J. Clin. Oncol., June 10, 2008; 26(17): 2916 - 2924.
[Abstract] [Full Text] [PDF]


Home page
The OncologistHome page
S. L. Spunt, S. X. Skapek, and C. M. Coffin
Pediatric Nonrhabdomyosarcoma Soft Tissue Sarcomas
Oncologist, June 1, 2008; 13(6): 668 - 678.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C.-H. Kwon, D. Zhao, J. Chen, S. Alcantara, Y. Li, D. K. Burns, R. P. Mason, E. Y.-H. P. Lee, H. Wu, and L. F. Parada
Pten Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas
Cancer Res., May 1, 2008; 68(9): 3286 - 3294.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. Soeda, A. Inagaki, N. Oka, Y. Ikegame, H. Aoki, S.-i. Yoshimura, S. Nakashima, T. Kunisada, and T. Iwama
Epidermal Growth Factor Plays a Crucial Role in Mitogenic Regulation of Human Brain Tumor Stem Cells
J. Biol. Chem., April 18, 2008; 283(16): 10958 - 10966.
[Abstract] [Full Text] [PDF]


Home page
GutHome page
L Ricci-Vitiani, A Pagliuca, E Palio, A Zeuner, and R De Maria
Colon cancer stem cells
Gut, April 1, 2008; 57(4): 538 - 548.
[Full Text] [PDF]


Home page
Cancer Res.Home page
K. Engelmann, H. Shen, and O. J. Finn
MCF7 Side Population Cells with Characteristics of Cancer Stem/Progenitor Cells Express the Tumor Antigen MUC1
Cancer Res., April 1, 2008; 68(7): 2419 - 2426.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
A. G. Gilg, S. L. Tye, L. B. Tolliver, W. G. Wheeler, R. P. Visconti, J. D. Duncan, F. V. Kostova, L. N. Bolds, B. P. Toole, and B. L. Maria
Targeting Hyaluronan Interactions in Malignant Gliomas and Their Drug-Resistant Multipotent Progenitors
Clin. Cancer Res., March 15, 2008; 14(6): 1804 - 1813.
[Abstract] [Full Text] [PDF]


Home page
Vet PatholHome page
M. M. Bera, D. N. R. Veeramachaneni, and K. Pandher
Characterization of a Biphasic Neoplasm in a Madagascar Tree Boa (Sanzinia madagascariensis)
Vet. Pathol., March 1, 2008; 45(2): 259 - 263.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
U. D. Lichtenauer, I. Shapiro, K. Geiger, M. Quinkler, M. Fassnacht, R. Nitschke, K.-D. Ruckauer, and F. Beuschlein
Side Population Does Not Define Stem Cell-Like Cancer Cells in the Adrenocortical Carcinoma Cell Line NCI h295R
Endocrinology, March 1, 2008; 149(3): 1314 - 1322.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
D. Hambardzumyan, O. J. Becher, M. K. Rosenblum, P. P. Pandolfi, K. Manova-Todorova, and E. C. Holland
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
Genes & Dev., February 15, 2008; 22(4): 436 - 448.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
S. Liu, C. Ginestier, E. Charafe-Jauffret, H. Foco, C. G. Kleer, S. D. Merajver, G. Dontu, and M. S. Wicha
BRCA1 regulates human mammary stem/progenitor cell fate
PNAS, February 5, 2008; 105(5): 1680 - 1685.
[Abstract] [Full Text] [PDF]


Home page
Phil Trans R Soc BHome page
P. B Dirks
Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells
Phil Trans R Soc B, January 12, 2008; 363(1489): 139 - 152.
[Abstract] [Full Text] [PDF]


Home page
Phil Trans R Soc BHome page
K. J.L Fernandes, J. G Toma, and F. D Miller
Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential
Phil Trans R Soc B, January 12, 2008; 363(1489): 185 - 198.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
L. M. Hansford, A. E. McKee, L. Zhang, R. E. George, J. T. Gerstle, P. S. Thorner, K. M. Smith, A. T. Look, H. Yeger, F. D. Miller, et al.
Neuroblastoma Cells Isolated from Bone Marrow Metastases Contain a Naturally Enriched Tumor-Initiating Cell
Cancer Res., December 1, 2007; 67(23): 11234 - 11243.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
F. B. Furnari, T. Fenton, R. M. Bachoo, A. Mukasa, J. M. Stommel, A. Stegh, W. C. Hahn, K. L. Ligon, D. N. Louis, C. Brennan, et al.
Malignant astrocytic glioma: genetics, biology, and paths to treatment
Genes & Dev., November 1, 2007; 21(21): 2683 - 2710.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
L. Nilsson, P. Eden, E. Olsson, R. Mansson, I. Astrand-Grundstrom, B. Strombeck, K. Theilgaard-Monch, K. Anderson, R. Hast, E. Hellstrom-Lindberg, et al.
The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes
Blood, October 15, 2007; 110(8): 3005 - 3014.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
R. P. Hill and R. Perris
"Destemming" Cancer Stem Cells
J Natl Cancer Inst, October 3, 2007; 99(19): 1435 - 1440.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. N. Rich
Cancer Stem Cells in Radiation Resistance
Cancer Res., October 1, 2007; 67(19): 8980 - 8984.
[Abstract] [Full Text] [PDF]


Home page
Ann OncolHome page
M. Mimeault and S. K. Batra
Interplay of distinct growth factors during epithelial mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies
Ann. Onc., October 1, 2007; 18(10): 1605 - 1619.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. Faber and S. A. Armstrong
Mixed Lineage Leukemia Translocations and a Leukemia Stem Cell Program
Cancer Res., September 15, 2007; 67(18): 8425 - 8428.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. C. Liu, T. Deng, R. S. Lehal, J. Kim, and E. Zacksenhaus
Identification of Tumorsphere- and Tumor-Initiating Cells in HER2/Neu-Induced Mammary Tumors
Cancer Res., September 15, 2007; 67(18): 8671 - 8681.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. Wu, Q. Wei, V. Utomo, P. Nadesan, H. Whetstone, R. Kandel, J. S. Wunder, and B. A. Alman
Side Population Cells Isolated from Mesenchymal Neoplasms Have Tumor Initiating Potential
Cancer Res., September 1, 2007; 67(17): 8216 - 8222.
[Abstract] [Full Text] [PDF]


Home page
GlycobiologyHome page
M. Yanagisawa and R. K Yu
The expression and functions of glycoconjugates in neural stem cells
Glycobiology, July 1, 2007; 17(7): 57R - 74R.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. V. Pfenninger, T. Roschupkina, F. Hertwig, D. Kottwitz, E. Englund, J. Bengzon, S. E. Jacobsen, and U. A. Nuber
CD133 Is Not Present on Neurogenic Astrocytes in the Adult Subventricular Zone, but on Embryonic Neural Stem Cells, Ependymal Cells, and Glioblastoma Cells
Cancer Res., June 15, 2007; 67(12): 5727 - 5736.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
D. Beier, P. Hau, M. Proescholdt, A. Lohmeier, J. Wischhusen, P. J. Oefner, L. Aigner, A. Brawanski, U. Bogdahn, and C. P. Beier
CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cells Show Differential Growth Characteristics and Molecular Profiles
Cancer Res., May 1, 2007; 67(9): 4010 - 4015.
[Abstract] [Full Text] [PDF]


Home page
Hum ReprodHome page
K. Kato, M. Yoshimoto, K. Kato, S. Adachi, A. Yamayoshi, T. Arima, K. Asanoma, S. Kyo, T. Nakahata, and N. Wake
Characterization of side-population cells in human normal endometrium
Hum. Reprod., May 1, 2007; 22(5): 1214 - 1223.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. Folkins, S. Man, P. Xu, Y. Shaked, D. J. Hicklin, and R. S. Kerbel
Anticancer Therapies Combining Antiangiogenic and Tumor Cell Cytotoxic Effects Reduce the Tumor Stem-Like Cell Fraction in Glioma Xenograft Tumors
Cancer Res., April 15, 2007; 67(8): 3560 - 3564.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
X. Zheng, G. Shen, X. Yang, and W. Liu
Most C6 Cells Are Cancer Stem Cells: Evidence from Clonal and Population Analyses
Cancer Res., April 15, 2007; 67(8): 3691 - 3697.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. Wang, L.-P. Guo, L.-Z. Chen, Y.-X. Zeng, and S. H. Lu
Identification of Cancer Stem Cell-Like Side Population Cells in Human Nasopharyngeal Carcinoma Cell Line
Cancer Res., April 15, 2007; 67(8): 3716 - 3724.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. Foroni, R. Galli, B. Cipelletti, A. Caumo, S. Alberti, R. Fiocco, and A. Vescovi
Resilience to Transformation and Inherent Genetic and Functional Stability of Adult Neural Stem Cells Ex vivo
Cancer Res., April 15, 2007; 67(8): 3725 - 3733.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
D. Faury, A. Nantel, S. E. Dunn, M.-C. Guiot, T. Haque, P. Hauser, M. Garami, L. Bognar, Z. Hanzely, P. P. Liberski, et al.
Molecular Profiling Identifies Prognostic Subgroups of Pediatric Glioblastoma and Shows Increased YB-1 Expression in Tumors
J. Clin. Oncol., April 1, 2007; 25(10): 1196 - 1208.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2003 by the American Association for Cancer Research.