| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262
Dysregulation of HOX gene expression has been implicated as a factor in malignancies for a number of years. However, no consensus has emerged regarding specific causative genes. Using a degenerate reverse transcription-PCR technique, we show up-regulation of genes from the HOXC cluster in malignant prostate cell lines and lymph node metastases. When relative expression levels of the four HOX clusters were examined, lymph node metastases and cell lines derived from lymph node metastases exhibited very similar patterns, patterns distinct from those in benign cells or malignant cell lines derived from other tumor sites. Specific reverse transcription-PCR for HOXC4 , HOXC5 , HOXC6 , and HOXC8 confirmed overexpression of these genes in malignant cell lines and lymph node metastases. Laser capture microdissection and examination of paired tumor/normal prostate epithelial cells also indicated overexpression of these HOXC genes in primary tumor cells. Our data indicate a possible link between expression of HOXC genes and malignancy in prostate cells. Overexpression of HOXC8 in LNCaP prostate cancer cells suppressed transactivation by androgen receptors. We speculate that HOXC overexpression may predispose tumor cells to androgen independence by necessitating adaptation to diminished androgen signaling.
This article has been cited by other articles:
|
|
 |
|
  Z.-D. Gu, L.-Y. Shen, H. Wang, X.-M. Chen, Y. Li, T. Ning, and K.-N. Chen HOXA13 Promotes Cancer Cell Growth and Predicts Poor Survival of Patients with Esophageal Squamous Cell Carcinoma Cancer Res., June 15, 2009; 69(12): 4969 - 4973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. McCabe, D. D. Spyropoulos, D. Martin, and C. S. Moreno Genome-Wide Analysis of the Homeobox C6 Transcriptional Network in Prostate Cancer Cancer Res., March 15, 2008; 68(6): 1988 - 1996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H-C J. Shen, J. E Rosen, L. M Yang, S. A Savage, A L. Burns, C. M Mateo, S. K Agarwal, S. C Chandrasekharappa, A. M Spiegel, F. S Collins, et al. Parathyroid tumor development involves deregulation of homeobox genes Endocr. Relat. Cancer, March 1, 2008; 15(1): 267 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Miao, Z. Wang, H. Provencher, B. Muir, S. Dahiya, E. Carney, C.-O. Leong, D. C. Sgroi, and S. Orsulic HOXB13 promotes ovarian cancer progression PNAS, October 23, 2007; 104(43): 17093 - 17098. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Abba, H. Sun, K. A. Hawkins, J. A. Drake, Y. Hu, M. I. Nunez, S. Gaddis, T. Shi, S. Horvath, A. Sahin, et al. Breast Cancer Molecular Signatures as Determined by SAGE: Correlation with Lymph Node Status Mol. Cancer Res., September 1, 2007; 5(9): 881 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Huang, Y. Pu, D. Hepps, D. Danielpour, and G. S. Prins Posterior Hox Gene Expression and Differential Androgen Regulation in the Developing and Adult Rat Prostate Lobes Endocrinology, March 1, 2007; 148(3): 1235 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wu, H. Chen, B. Parker, E. Rubin, T. Zhu, J. S. Lee, P. Argani, and S. Sukumar HOXB7, a Homeodomain Protein, Is Overexpressed in Breast Cancer and Confers Epithelial-Mesenchymal Transition Cancer Res., October 1, 2006; 66(19): 9527 - 9534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lei, A. H. Juan, M.-S. Kim, and F. H. Ruddle Identification of a Hoxc8-regulated transcriptional network in mouse embryo fibroblast cells PNAS, July 5, 2006; 103(27): 10305 - 10309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mendrzyk, A. Korshunov, A. Benner, G. Toedt, S. Pfister, B. Radlwimmer, and P. Lichter Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma. Clin. Cancer Res., April 1, 2006; 12(7): 2070 - 2079. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mimeault and S. K. Batra Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies Carcinogenesis, January 1, 2006; 27(1): 1 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lei, H. Wang, A. H. Juan, and F. H. Ruddle The identification of Hoxc8 target genes PNAS, February 15, 2005; 102(7): 2420 - 2424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-N. Chen, Z.-D. Gu, Y. Ke, J.-Y. Li, X.-T. Shi, and G.-W. Xu Expression of 11 HOX Genes Is Deregulated in Esophageal Squamous Cell Carcinoma Clin. Cancer Res., February 1, 2005; 11(3): 1044 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Shappell, G. V. Thomas, R. L. Roberts, R. Herbert, M. M. Ittmann, M. A. Rubin, P. A. Humphrey, J. P. Sundberg, N. Rozengurt, R. Barrios, et al. Prostate Pathology of Genetically Engineered Mice: Definitions and Classification. The Consensus Report from the Bar Harbor Meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee Cancer Res., March 15, 2004; 64(6): 2270 - 2305. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
