Cancer Research AACR Conference on Molecular Diagnostics - 2008 AACR Conference on Molecular Diagnostics - 2008
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Twine, N. C.
Right arrow Articles by Burczynski, M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Twine, N. C.
Right arrow Articles by Burczynski, M. E.
[Cancer Research 63, 6069-6075, September 15, 2003]
© 2003 American Association for Cancer Research

Regular Articles

Disease-associated Expression Profiles in Peripheral Blood Mononuclear Cells from Patients with Advanced Renal Cell Carcinoma

Natalie C. Twine, Jennifer A. Stover, Bonnie Marshall, Gary Dukart, Manuel Hidalgo, Walter Stadler, Theodore Logan, Janice Dutcher, Gary Hudes, Andrew J. Dorner, Donna K. Slonim, William L. Trepicchio1 and Michael E. Burczynski2

Discovery Medicine [N. C. T., J. A. S., A. J. D., W. L. T., M. E. B.] and Expression Profiling Informatics [D. K. S.], Wyeth Research, Cambridge, Massachusetts 02140; Clinical Research and Development, Wyeth Research, Collegeville, Pennsylvania 19426 [B. M., G. D.]; University of Texas Health Science Center, San Antonio, Texas 78229 [M. H.]; University of Chicago, Chicago, Illinois 60637 [W. S.]; Indiana University, Indianapolis, Indiana 85012 [T. L.]; Our Lady of Mercy Medical Center, New York Medical College, Bronx, New York 10466 [J. D.]; and Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 [G. H.]

Expression profiling has demonstrated that transcriptomes of primary malignancies differ from those in normal tissue. It is unknown, however, whether there exist "surrogate" transcriptional markers in peripheral blood mononuclear cells (PBMCs) of patients with solid tumors. We identified transcripts expressed differentially between PBMCs from renal cell carcinoma patients and normal subjects, some of which appear to reflect specific immune responses of circulating cells. We also identified small sets of predictor genes distinguishing PBMCs from renal cell carcinoma patients and normal volunteers with high accuracy. The present findings have important implications for diagnosis and future clinical pharmacogenomic studies of antitumor therapies.




This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
Y. Bosse, P. Mathieu, and P. Pibarot
Genomics: The Next Step to Elucidate the Etiology of Calcific Aortic Valve Stenosis
J. Am. Coll. Cardiol., April 8, 2008; 51(14): 1327 - 1336.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. J. Kim, D. J. Dix, K. E. Thompson, R. N. Murrell, J. E. Schmid, J. E. Gallagher, and J. C. Rockett
Effects of Storage, RNA Extraction, Genechip Type, and Donor Sex on Gene Expression Profiling of Human Whole Blood
Clin. Chem., June 1, 2007; 53(6): 1038 - 1045.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
I. Osman, D. F. Bajorin, T.-T. Sun, H. Zhong, D. Douglas, J. Scattergood, R. Zheng, M. Han, K. W. Marshall, and C.-C. Liew
Novel blood biomarkers of human urinary bladder cancer.
Clin. Cancer Res., June 1, 2006; 12(11): 3374 - 3380.
[Abstract] [Full Text] [PDF]

Home page
 Annals of Clinical & Laboratory ScienceHome page
S. J. Kim, D. J. Dix, K. E. Thompson, R. N. Murrell, J. E. Schmid, J. E. Gallagher, and J. C. Rockett
Gene expression in head hair follicles plucked from men and women.
Ann. Clin. Lab. Sci., March 1, 2006; 36(2): 115 - 126.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
M. E. Burczynski, R. L. Peterson, N. C. Twine, K. A. Zuberek, B. J. Brodeur, L. Casciotti, V. Maganti, P. S. Reddy, A. Strahs, F. Immermann, et al.
Molecular Classification of Crohn's Disease and Ulcerative Colitis Patients Using Transcriptional Profiles in Peripheral Blood Mononuclear Cells
J. Mol. Diagn., February 1, 2006; 8(1): 51 - 61.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. E. Burczynski, N. C. Twine, G. Dukart, B. Marshall, M. Hidalgo, W. M. Stadler, T. Logan, J. Dutcher, G. Hudes, W. L. Trepicchio, et al.
Transcriptional Profiles in Peripheral Blood Mononuclear Cells Prognostic of Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma
Clin. Cancer Res., February 1, 2005; 11(3): 1181 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M.-H. Tan, C. G. Rogers, J. T. Cooper, J. A. Ditlev, T. J. Maatman, X. Yang, K. A. Furge, and B. T. Teh
Gene Expression Profiling of Renal Cell Carcinoma
Clin. Cancer Res., September 15, 2004; 10(18): 6315S - 6321S.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Xu, C.-T. Shu, E. Purdom, D. Dang, D. Ilsley, Y. Guo, J. Weber, S. P. Holmes, and P. P. Lee
Microarray Analysis Reveals Differences in Gene Expression of Circulating CD8+ T Cells in Melanoma Patients and Healthy Donors
Cancer Res., May 15, 2004; 64(10): 3661 - 3667.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2003 by the American Association for Cancer Research.