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[Cancer Research 63, 6125-6129, October 1, 2003]
© 2003 American Association for Cancer Research

Advances in Brief

Different Susceptibility of Human Mesothelial Cells to Polyomavirus Infection and Malignant Transformation1

Michele Carbone2, Carol Burck, Monica Rdzanek, Jennifer Rudzinski, Rochelle Cutrone and Maurizio Bocchetta

Cardinal Bernardin Cancer Center, Department of Pathology, Loyola University Chicago, Maywood Illinois 60153

SV40 has been associated with mesothelioma development. The possible role of the closely related human polyomaviruses JC virus (JCV) and BK virus (BKV) in mesothelioma remained unclear. We found that JCV did not infect human mesothelial cells. BKV and SV40 infected mesothelial cells, expressed viral oncoproteins, and caused similar alterations of key cell regulatory genes. BKV replicated faster than SV40 and caused mesothelial cell lysis, not cellular transformation. SV40 did not lyse mesothelial cells and caused a high rate of transformation. These findings provide a rationale for the observation that SV40 is found in mesothelioma, rather than the ubiquitous human JCV and BKV.




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Copyright © 2003 by the American Association for Cancer Research.