| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Advances in Brief |
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030
Limited hormonal stimulation of the mammary gland during a critical window in postpubertal development imparts a long-lasting protective effect against breast cancer in humans and in rodent models. The hormonal stimulation can be achieved by full-term pregnancy or low doses of estradiol-17ß and progesterone administered for 21 days. The mechanism(s) behind this effect of hormones is not understood at the molecular level. The experiments reported here demonstrate that the absence of p53 tumor suppressor gene function abrogates the protective effect of hormones against carcinogen-induced mammary carcinogenesis in BALB/c mice. This is the first identification of a specific gene product that mediates the protective effect of hormones. Additionally, the experiments highlight the usefulness of transgenic mouse models in the testing of hypotheses derived from the classic rat mammary models.
This article has been cited by other articles:
|
|
 |
|
  R. Moral, R. Wang, I. H Russo, C. A Lamartiniere, J. Pereira, and J. Russo Effect of prenatal exposure to the endocrine disruptor bisphenol A on mammary gland morphology and gene expression signature J. Endocrinol., January 1, 2008; 196(1): 101 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Loehberg, T. Thompson, M. B. Kastan, K. H. Maclean, D. G. Edwards, F. S. Kittrell, D. Medina, O. M. Conneely, and B. W. O'Malley Ataxia Telangiectasia-Mutated and p53 Are Potential Mediators of Chloroquine-Induced Resistance to Mammary Carcinogenesis Cancer Res., December 15, 2007; 67(24): 12026 - 12033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Abba, V. T. Fabris, Y. Hu, F. S. Kittrell, W.-W. Cai, L. A. Donehower, A. Sahin, D. Medina, and C. M. Aldaz Identification of Novel Amplification Gene Targets in Mouse and Human Breast Cancer at a Syntenic Cluster Mapping to Mouse ch8A1 and Human ch13q34 Cancer Res., May 1, 2007; 67(9): 4104 - 4112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Blakely, A. J. Stoddard, G. K. Belka, K. D. Dugan, K. L. Notarfrancesco, S. E. Moody, C. M. D'Cruz, and L. A. Chodosh Hormone-Induced Protection against Mammary Tumorigenesis Is Conserved in Multiple Rat Strains and Identifies a Core Gene Expression Signature Induced by Pregnancy. Cancer Res., June 15, 2006; 66(12): 6421 - 6431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C Fleisch, C. A Maxwell, and M.-H. Barcellos-Hoff The pleiotropic roles of transforming growth factor beta in homeostasis and carcinogenesis of endocrine organs. Endocr. Relat. Cancer, June 1, 2006; 13(2): 379 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Medina Mammary developmental fate and breast cancer risk Endocr. Relat. Cancer, September 1, 2005; 12(3): 483 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tu, D. J. Jerry, B. Pazik, and S. Smith Schneider Sensitivity to DNA Damage Is a Common Component of Hormone-Based Strategies for Protection of the Mammary Gland Mol. Cancer Res., August 1, 2005; 3(8): 435 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Meniel, T. Hay, A. Douglas-Jones, O. J. Sansom, and A. R. Clarke Mutations in Apc and p53 Synergize to Promote Mammary Neoplasia Cancer Res., January 15, 2005; 65(2): 410 - 416. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
