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Insulin-like Growth Factor II Receptor Gene-167 Genotype Increases the Risk of Oral Squamous Cell Carcinoma in Humans¹

Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, Massachusetts 02115 [A. I. Z., W. P., V. C., A. L., C. W. D.]; Department of Community Dentistry, Faculty of Dentistry, Khon Kaen University, Thailand 40002 [W. P.]; Craniofacial Epidemiology and Genetics Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892-6401 [T. W., S. R. D.]; and Center for Pharmacogenomics and Complex Disease Research, New Jersey Dental School, Newark, New Jersey 07101-1709 [S. R. D.]

Our purpose was to evaluate inherited short tandem repeat polymorphisms of the insulin-like growth factor II receptor gene (IGF2R) in oral cancer risk. The 197 individuals that consented to participate in a hospital-based, case-control study were interviewed with a structured questionnaire and provided blood and saliva. DNA was extracted for genotyping using a PCR-based method. Odds ratios were calculated using multivariate logistic regression. Subjects carrying the heterozygous 167-bp IGF2R genotype had a 2.7-fold higher risk of oral cancer compared with subjects with other genotypes (odds ratio = 2.7, 95% confidence interval: 1.16–6.48), controlling for major confounders. Our results suggest that genetic variation of IGF2R may influence significantly the risk of oral cancer.

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