| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Advances in Brief |
Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts 02115 [C. A. F., J. A. F.]; Departments of Pathology [A. R. P-A.], and Medicine [H. E. G., J. A. F.], Children’s Hospital, Boston, Massachusetts 02115; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115 [H. E. G., J. A. F.]; and Kochi Medical School, Okohcho, Nankoku, Kochi, Japan 783-8505 [I. M., I. K.]
The poorly differentiated carcinoma with t(15;19)(q13, p13.1) is characterized by its highly aggressive, invariably lethal clinical course. The chromosome 19 translocation breakpoint targets the BRD4 double bromodomain-containing gene, which functions in regulation of cell cycle progression. Herein we demonstrate that BRD4 is fused with nearly the entire transcript of the novel 15q13 gene, NUT (nuclear protein in testis), forming a 6.4-kb fusion oncogene, BRD4-NUT. NUT, like BRD4, is predicted to encode a nuclear protein but, unlike the ubiquitous BRD4 transcript, is expressed only in testis. These findings establish a model to elucidate the oncogenic consequences of unscheduled NUT expression and altered BRD4 function. Very few fusion oncogenes have been identified in epithelial tumors, and BRD4-NUT is the first fusion oncogene mechanism identified in a highly lethal form of carcinoma.
This article has been cited by other articles:
|
|
 |
|
  J. L. Ordonez, D. Osuna, D. Herrero, E. de Alava, and J. Madoz-Gurpide Advances in Ewing's Sarcoma Research: Where Are We Now and What Lies Ahead? Cancer Res., September 15, 2009; 69(18): 7140 - 7150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Zheng, M.-R. Schweiger, G. Martinez-Noel, L. Zheng, J. A. Smith, J. W. Harper, and P. M. Howley Brd4 Regulation of Papillomavirus Protein E2 Stability J. Virol., September 1, 2009; 83(17): 8683 - 8692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Y. Wu and C.-M. Chiang The Double Bromodomain-containing Chromatin Adaptor Brd4 and Transcriptional Regulation J. Biol. Chem., May 4, 2007; 282(18): 13141 - 13145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Lenburg, A. Sinha, D. V. Faller, and G. V. Denis Tumor-specific and Proliferation-specific Gene Expression Typifies Murine Transgenic B Cell Lymphomagenesis J. Biol. Chem., February 16, 2007; 282(7): 4803 - 4811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ottinger, T. Christalla, K. Nathan, M. M. Brinkmann, A. Viejo-Borbolla, and T. F. Schulz Kaposi's Sarcoma-Associated Herpesvirus LANA-1 Interacts with the Short Variant of BRD4 and Releases Cells from a BRD4- and BRD2/RING3-Induced G1 Cell Cycle Arrest J. Virol., November 1, 2006; 80(21): 10772 - 10786. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Y. Wu, A-Y. Lee, S. Y. Hou, J. K. Kemper, H. Erdjument-Bromage, P. Tempst, and C.-M. Chiang Brd4 links chromatin targeting to HPV transcriptional silencing Genes & Dev., September 1, 2006; 20(17): 2383 - 2396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Haruki, K S Kawaguchi, S Eichenberger, P P Massion, A Gonzalez, A F Gazdar, J D Minna, D P Carbone, and T P Dang Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro J. Med. Genet., July 1, 2005; 42(7): 558 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. French, J. L. Kutok, W. C. Faquin, J. A. Toretsky, C. R. Antonescu, C. A. Griffin, V. Nose, S. O. Vargas, M. Moschovi, F. Tzortzatou-Stathopoulou, et al. Midline Carcinoma of Children and Young Adults With NUT Rearrangement J. Clin. Oncol., October 15, 2004; 22(20): 4135 - 4139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Greenwald, J. R. Tumang, A. Sinha, N. Currier, R. D. Cardiff, T. L. Rothstein, D. V. Faller, and G. V. Denis E{micro}-BRD2 transgenic mice develop B-cell lymphoma and leukemia Blood, February 15, 2004; 103(4): 1475 - 1484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Pivot-Pajot, C. Caron, J. Govin, A. Vion, S. Rousseaux, and S. Khochbin Acetylation-Dependent Chromatin Reorganization by BRDT, a Testis-Specific Bromodomain-Containing Protein Mol. Cell. Biol., August 1, 2003; 23(15): 5354 - 5365. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
