This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fan, P.-D. Articles by Goff, S. P. Search for Related Content PubMed PubMed Citation Articles by Fan, P.-D. Articles by Goff, S. P.

Homo- and Hetero-Oligomerization of the c-Abl Kinase and Abelson-Interactor-1

Integrated Program in Cellular, Molecular and Biophysical Studies [P-D. F.], Department of Biological Sciences [F. C.], Howard Hughes Medical Institute [S. P. G.], and Department of Biochemistry and Molecular Biophysics [S. P. G.], Columbia University College of Physicians and Surgeons, New York, New York 10032

Oligomerization of the nonreceptor tyrosine kinase c-Abl can activate its transforming potential. Domains mediating oligomerization within the BCR-ABL and TEL-ABL oncoproteins are required for transforming activity, and fusion of inducible dimerization domains to c-Abl can generate chimeric proteins with dimerization-dependent transforming activity. We have found that c-Abl oligomerizes at high levels of expression in COS cells. This interaction is dependent on kinase activity and an intact NH₂-terminal region of c-Abl. A binding partner of c-Abl, Abl-interactor-1 (Abi-1), similarly oligomerizes in COS cells. An oligomeric form of Abi-1 interacts with Abl both in vitro and in mammalian cells. These results suggest the possibility that oligomerization of Abl kinases, perhaps involving regulation by their interaction partners, may play a role in modulation of kinase activity in both normal and oncogenic processes.

This article has been cited by other articles:

				X. Luo, E. Levens, R. S. Williams, and N. Chegini The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta Hum. Reprod., June 1, 2006; 21(6): 1380 - 1386. [Abstract] [Full Text] [PDF]

				A. Echarri, M. J. Lai, M. R. Robinson, and A. M. Pendergast Abl Interactor 1 (Abi-1) Wave-Binding and SNARE Domains Regulate Its Nucleocytoplasmic Shuttling, Lamellipodium Localization, and Wave-1 Levels Mol. Cell. Biol., June 1, 2004; 24(11): 4979 - 4993. [Abstract] [Full Text] [PDF]

				T. Beissert, E. Puccetti, A. Bianchini, S. Guller, S. Boehrer, D. Hoelzer, O. G. Ottmann, C. Nervi, and M. Ruthardt Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571 Blood, October 15, 2003; 102(8): 2985 - 2993. [Abstract] [Full Text] [PDF]