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[Cancer Research 63, 1101-1105, March 1, 2003]
© 2003 American Association for Cancer Research

Tumor Biology

Tissue Microarray Analysis of Hepatocyte Growth Factor/Met Pathway Components Reveals a Role for Met, Matriptase, and Hepatocyte Growth Factor Activator Inhibitor 1 in the Progression of Node-negative Breast Cancer1

Jung Y. Kang, Marisa Dolled-Filhart, Idris Tolgay Ocal, Baljit Singh, Chen-Yong Lin, Robert B. Dickson, David L. Rimm and Robert L. Camp2

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 [J. Y. K., M. D-F., I. T. O., D. L. R., R. L. C.], and Lombardi Cancer Center, Departments of Oncology and Pathology, Georgetown University School of Medicine, Washington, DC 20007 [B. S., C-Y. L., R. B. D.]

Numerous studies have demonstrated that overexpression of Met, the hepatocyte growth factor(HGF) receptor, plays an important role in tumorigenesis. Met activation can either occur through ligand-independent or -dependent mechanisms, both of which are mediated by a series of proteases and modulators. We studied the protein expression of several components of the HGF/Met pathway on a cohort of 330 node-negative breast carcinomas using a tissue microarray annotated with 30-year, disease-specific patient follow-up data. We examined HGF, matriptase (an activator of HGF expressed on mammary epithelial cell surfaces), HAI-I (the cognate inhibitor of matriptase), and the Met receptor itself. Our studies demonstrate tight correlation between the expression of HGF, matriptase, and Met in breast carcinoma. High-level expression of Met, matriptase, and HAI-I were associated with poor patient outcome. Met and HAI-I showed independent prognostic value when compared with traditional breast markers in a multivariate analysis. Intriguingly, antibodies against the intracellular but not the extracellular domain of Met were prognostic, suggesting that overexpression of the cytoplasmic-tail of Met, perhaps through cleavage or truncating mutation, may play an important role in breast cancer progression.




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