Cancer Research Prevention Award Advances in Breast Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kang, J. Y.
Right arrow Articles by Camp, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kang, J. Y.
Right arrow Articles by Camp, R. L.
[Cancer Research 63, 1101-1105, March 1, 2003]
© 2003 American Association for Cancer Research

Tumor Biology

Tissue Microarray Analysis of Hepatocyte Growth Factor/Met Pathway Components Reveals a Role for Met, Matriptase, and Hepatocyte Growth Factor Activator Inhibitor 1 in the Progression of Node-negative Breast Cancer1

Jung Y. Kang, Marisa Dolled-Filhart, Idris Tolgay Ocal, Baljit Singh, Chen-Yong Lin, Robert B. Dickson, David L. Rimm and Robert L. Camp2

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 [J. Y. K., M. D-F., I. T. O., D. L. R., R. L. C.], and Lombardi Cancer Center, Departments of Oncology and Pathology, Georgetown University School of Medicine, Washington, DC 20007 [B. S., C-Y. L., R. B. D.]

Numerous studies have demonstrated that overexpression of Met, the hepatocyte growth factor(HGF) receptor, plays an important role in tumorigenesis. Met activation can either occur through ligand-independent or -dependent mechanisms, both of which are mediated by a series of proteases and modulators. We studied the protein expression of several components of the HGF/Met pathway on a cohort of 330 node-negative breast carcinomas using a tissue microarray annotated with 30-year, disease-specific patient follow-up data. We examined HGF, matriptase (an activator of HGF expressed on mammary epithelial cell surfaces), HAI-I (the cognate inhibitor of matriptase), and the Met receptor itself. Our studies demonstrate tight correlation between the expression of HGF, matriptase, and Met in breast carcinoma. High-level expression of Met, matriptase, and HAI-I were associated with poor patient outcome. Met and HAI-I showed independent prognostic value when compared with traditional breast markers in a multivariate analysis. Intriguingly, antibodies against the intracellular but not the extracellular domain of Met were prognostic, suggesting that overexpression of the cytoplasmic-tail of Met, perhaps through cleavage or truncating mutation, may play an important role in breast cancer progression.




This article has been cited by other articles:


Home page
 CarcinogenesisHome page
E. Matteucci, P. Bendinelli, and M. A. Desiderio
Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cells
Carcinogenesis, June 1, 2009; 30(6): 937 - 945.
[Abstract] [Full Text] [PDF]

Home page
 Anticancer ResHome page
K. NAKAMURA, A. HONGO, J. KODAMA, F. ABARZUA, Y. NASU, H. KUMON, and Y. HIRAMATSU
Expression of Matriptase and Clinical Outcome of Human Endometrial Cancer
Anticancer Res, May 1, 2009; 29(5): 1685 - 1690.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
G. Bonuccelli, M. C. Casimiro, F. Sotgia, C. Wang, M. Liu, S. Katiyar, J. Zhou, E. Dew, F. Capozza, K. M. Daumer, et al.
Caveolin-1 (P132L), a Common Breast Cancer Mutation, Confers Mammary Cell Invasiveness and Defines a Novel Stem Cell/Metastasis-Associated Gene Signature
Am. J. Pathol., May 1, 2009; 174(5): 1650 - 1662.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Fan, Q. Meng, J. J. Laterra, and E. M. Rosen
Role of Src Signal Transduction Pathways in Scatter Factor-mediated Cellular Protection
J. Biol. Chem., March 20, 2009; 284(12): 7561 - 7577.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Ginty, S. Adak, A. Can, M. Gerdes, M. Larsen, H. Cline, R. Filkins, Z. Pang, Q. Li, and M. C. Montalto
The Relative Distribution of Membranous and Cytoplasmic Met Is a Prognostic Indicator in Stage I and II Colon Cancer
Clin. Cancer Res., June 15, 2008; 14(12): 3814 - 3822.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Desilets, F. Beliveau, G. Vandal, F.-O. McDuff, P. Lavigne, and R. Leduc
Mutation G827R in Matriptase Causing Autosomal Recessive Ichthyosis with Hypotrichosis Yields an Inactive Protease
J. Biol. Chem., April 18, 2008; 283(16): 10535 - 10542.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. L. Shattuck, J. K. Miller, K. L. Carraway III, and C. Sweeney
Met Receptor Contributes to Trastuzumab Resistance of Her2-Overexpressing Breast Cancer Cells
Cancer Res., March 1, 2008; 68(5): 1471 - 1477.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Milstein, C. K. Mooser, H. Hu, M. Fejzo, D. Slamon, L. Goodglick, S. Dry, and J. Colicelli
RIN1 Is a Breast Tumor Suppressor Gene
Cancer Res., December 15, 2007; 67(24): 11510 - 11516.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M.-S. Lee, I-C. Tseng, Y. Wang, K.-i. Kiyomiya, M. D. Johnson, R. B. Dickson, and C.-Y. Lin
Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain
Am J Physiol Cell Physiol, July 1, 2007; 293(1): C95 - C105.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. Parr, A. J. Sanders, G. Davies, T. Martin, J. Lane, M. D. Mason, R. E. Mansel, and W. G. Jiang
Matriptase-2 Inhibits Breast Tumor Growth and Invasion and Correlates with Favorable Prognosis for Breast Cancer Patients
Clin. Cancer Res., June 15, 2007; 13(12): 3568 - 3576.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. L. Welm, J. B. Sneddon, C. Taylor, D. S. A. Nuyten, M. J. van de Vijver, B. H. Hasegawa, and J. M. Bishop
The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans
PNAS, May 1, 2007; 104(18): 7570 - 7575.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. S. Bhatt, A. Welm, C. J. Farady, M. Vasquez, K. Wilson, and C. S. Craik
Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway
PNAS, April 3, 2007; 104(14): 5771 - 5776.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. L. Shattuck, J. K. Miller, M. Laederich, M. Funes, H. Petersen, K. L. Carraway III, and C. Sweeney
LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy
Mol. Cell. Biol., March 1, 2007; 27(5): 1934 - 1946.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Sawada, A. R. Radjabi, N. Shinomiya, E. Kistner, H. Kenny, A. R. Becker, M. A. Turkyilmaz, R. Salgia, S. D. Yamada, G. F. Vande Woude, et al.
c-Met Overexpression Is a Prognostic Factor in Ovarian Cancer and an Effective Target for Inhibition of Peritoneal Dissemination and Invasion
Cancer Res., February 15, 2007; 67(4): 1670 - 1679.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. Generali, S. B. Fox, A. Berruti, J. W. Moore, M. P. Brizzi, N. Patel, G. Allevi, S. Bonardi, S. Aguggini, A. Bersiga, et al.
Regulation of Hepatocyte Growth Factor Activator Inhibitor 2 by Hypoxia in Breast Cancer
Clin. Cancer Res., January 15, 2007; 13(2): 550 - 558.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Netzel-Arnett, B. M. Currie, R. Szabo, C.-Y. Lin, L.-M. Chen, K. X. Chai, T. M. Antalis, T. H. Bugge, and K. List
Evidence for a Matriptase-Prostasin Proteolytic Cascade Regulating Terminal Epidermal Differentiation
J. Biol. Chem., November 3, 2006; 281(44): 32941 - 32945.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Pozner-Moulis, D. J. Pappas, and D. L. Rimm
Met, the Hepatocyte Growth Factor Receptor, Localizes to the Nucleus in Cells at Low Density
Cancer Res., August 15, 2006; 66(16): 7976 - 7982.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
K.-i. Kiyomiya, M.-S. Lee, I-C. Tseng, H. Zuo, R. J. Barndt, M. D. Johnson, R. B. Dickson, and C.-Y. Lin
Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells
Am J Physiol Cell Physiol, July 1, 2006; 291(1): C40 - C49.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Dolled-Filhart, A. McCabe, J. Giltnane, M. Cregger, R. L. Camp, and D. L. Rimm
Quantitative In situ Analysis of {beta}-Catenin Expression in Breast Cancer Shows Decreased Expression Is Associated with Poor Outcome.
Cancer Res., May 15, 2006; 66(10): 5487 - 5494.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. List, R. Szabo, A. Molinolo, B. S. Nielsen, and T. H. Bugge
Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis
Am. J. Pathol., May 1, 2006; 168(5): 1513 - 1525.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. A. Smolen, B. Muir, G. Mohapatra, A. Barmettler, W. J. Kim, M. N. Rivera, S. M. Haserlat, R. A. Okimoto, E. Kwak, S. Dahiya, et al.
Frequent met oncogene amplification in a brca1/trp53 mouse model of mammary tumorigenesis.
Cancer Res., April 1, 2006; 66(7): 3452 - 3455.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Ge, H. Hu, K. Ding, L. Sun, and S. Zheng
Protein Interaction Analysis of ST14 Domains and Their Point and Deletion Mutants
J. Biol. Chem., March 17, 2006; 281(11): 7406 - 7412.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. S. Kim, C. Heinlein, R. C. Hackman, and P. S. Nelson
Phenotypic Analysis of Mice Lacking the Tmprss2-Encoded Protease
Mol. Cell. Biol., February 1, 2006; 26(3): 965 - 975.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. Saleem, V. M. Adhami, W. Zhong, B. J. Longley, C.-Y. Lin, R. B. Dickson, S. Reagan-Shaw, D. F. Jarrard, and H. Mukhtar
A novel biomarker for staging human prostate adenocarcinoma: overexpression of matriptase with concomitant loss of its inhibitor, hepatocyte growth factor activator inhibitor-1.
Cancer Epidemiol. Biomarkers Prev., February 1, 2006; 15(2): 217 - 227.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. McCabe, M. Dolled-Filhart, R. L. Camp, and D. L. Rimm
Automated Quantitative Analysis (AQUA) of In Situ Protein Expression, Antibody Concentration, and Prognosis
J Natl Cancer Inst, December 21, 2005; 97(24): 1808 - 1815.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. F. Siddiqui, J. Pawelek, T. Handerson, C.-Y. Lin, R. B. Dickson, D. L. Rimm, and R. L. Camp
Coexpression of {beta}1,6-N-Acetylglucosaminyltransferase V Glycoprotein Substrates Defines Aggressive Breast Cancers with Poor Outcome
Cancer Epidemiol. Biomarkers Prev., November 1, 2005; 14(11): 2517 - 2523.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
K. List, R. Szabo, A. Molinolo, V. Sriuranpong, V. Redeye, T. Murdock, B. Burke, B. S. Nielsen, J. S. Gutkind, and T. H. Bugge
Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation
Genes & Dev., August 15, 2005; 19(16): 1934 - 1950.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
B. S. Knudsen, J. M. Lucas, L. Fazli, S. Hawley, S. Falcon, I. M. Coleman, D. B. Martin, C. Xu, L. D. True, M. E. Gleave, et al.
Regulation of Hepatocyte Activator Inhibitor-1 Expression by Androgen and Oncogenic Transformation in the Prostate
Am. J. Pathol., July 1, 2005; 167(1): 255 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Handerson, R. Camp, M. Harigopal, D. Rimm, and J. Pawelek
{beta}1,6-Branched Oligosaccharides Are Increased in Lymph Node Metastases and Predict Poor Outcome in Breast Carcinoma
Clin. Cancer Res., April 15, 2005; 11(8): 2969 - 2973.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M.-S. Lee, K.-i. Kiyomiya, C. Benaud, R. B. Dickson, and C.-Y. Lin
Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells
Am J Physiol Cell Physiol, April 1, 2005; 288(4): C932 - C941.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
H. Khoury, M. A. Naujokas, D. Zuo, V. Sangwan, M. M. Frigault, S. Petkiewicz, D. L. Dankort, W. J. Muller, and M. Park
HGF Converts ErbB2/Neu Epithelial Morphogenesis to Cell Invasion
Mol. Biol. Cell, February 1, 2005; 16(2): 550 - 561.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
A Noel, C Maillard, N Rocks, M Jost, V Chabottaux, N E Sounni, E Maquoi, D Cataldo, and J M Foidart
Membrane associated proteases and their inhibitors in tumour angiogenesis
J. Clin. Pathol., June 1, 2004; 57(6): 577 - 584.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R.-J. Hung, I.-W. J. Hsu, J. L. Dreiling, M.-J. Lee, C. A. Williams, M. D. Oberst, R. B. Dickson, and C.-Y. Lin
Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts
Am J Physiol Cell Physiol, May 1, 2004; 286(5): C1159 - C1169.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
S. Ihara, E. Miyoshi, S. Nakahara, H. Sakiyama, H. Ihara, A. Akinaga, K. Honke, R. B. Dickson, C.-Y. Lin, and N. Taniguchi
Addition of {beta}1-6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against trypsin
Glycobiology, February 1, 2004; 14(2): 139 - 146.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. Parr, G. Watkins, R. E. Mansel, and W. G. Jiang
The Hepatocyte Growth Factor Regulatory Factors in Human Breast Cancer
Clin. Cancer Res., January 1, 2004; 10(1): 202 - 211.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Walter-Yohrling, X. Cao, M. Callahan, W. Weber, S. Morgenbesser, S. L. Madden, C. Wang, and B. A. Teicher
Identification of Genes Expressed in Malignant Cells That Promote Invasion
Cancer Res., December 15, 2003; 63(24): 8939 - 8947.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. A. Davol, R. Bagdasaryan, G. J. Elfenbein, A. L. Maizel, and A. R. Frackelton Jr.
Shc Proteins Are Strong, Independent Prognostic Markers for Both Node-Negative and Node-Positive Primary Breast Cancer
Cancer Res., October 15, 2003; 63(20): 6772 - 6783.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Kirchhofer, M. Peek, W. Li, J. Stamos, C. Eigenbrot, S. Kadkhodayan, J. M. Elliott, R. T. Corpuz, R. A. Lazarus, and P. Moran
Tissue Expression, Protease Specificity, and Kunitz Domain Functions of Hepatocyte Growth Factor Activator Inhibitor-1B (HAI-1B), a New Splice Variant of HAI-1
J. Biol. Chem., September 19, 2003; 278(38): 36341 - 36349.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. D. Oberst, C. A. Williams, R. B. Dickson, M. D. Johnson, and C.-Y. Lin
The Activation of Matriptase Requires Its Noncatalytic Domains, Serine Protease Domain, and Its Cognate Inhibitor
J. Biol. Chem., July 11, 2003; 278(29): 26773 - 26779.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2003 by the American Association for Cancer Research.